| Project/Area Number |
20300164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
SUGIMACHI Masaru National Cardiovascular Center Research Institute, 循環動態制御部, 部長 (40250261)
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| Co-Investigator(Kenkyū-buntansha) |
SHISHIDO Toshiaki 独立行政法人国立循環器病研究センター, 研究企画調節室, 室長 (60300977)
SHIMIZU Shuji 独立行政法人国立循環器病研究センター, 循環動態制御部, 特任研究員 (80443498)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 自動治療 / システム同定 / マクロ血行動態モデル / オンラインシステム同定 |
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| Research Abstract |
We developed a method to treat heart failure by automatically and quantitatively determining the dose of inotropics on left-heart pump function, vasodilators on vascular resistance, fluids on blood volume. These cardiovascular properties were obtained quantitatively using a comprehensive cardiovascular model. Due to the dependency of biological drug response on subjects, pathological states, operating points, however, it is desirable to develop an adaptive control. For online system identification, which is an essential requirement for adaptive controls, an external minute perturbation was required. Biological drug responses such obtained are likely usable for the automatic treatment.
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