Experimental evidence of in situ capture of endothelial progenitor cells on luminal surface of artificial grafts in bloodstream on porcein model.
| Project/Area Number |
20300171
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kanazawa Institute of Technology |
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Principal Investigator |
MATSUDA Takehisa Kanazawa Institute of Technology, ゲノム生物工学研究所, 教授 (60142189)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Go 金沢大学, 医学(系)研究科(研究院), 教授 (60242492)
OOTAKE Hiroshi 金沢大学, 医学(系)研究科(研究院), 特任教授 (60283131)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2008: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
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| Keywords | 生体材料 / 細胞組織 / 人工血管 / 生体力学 / 動物実験 / 生物材料 |
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| Research Abstract |
This study aims at in situ capture of endothelial progenitor cells (EPCs) on blood-contacting surfaces of cardiovascular devices in bloodstream. Among various cell surface receptor/legend pairs, only surface-bound VEGF/VEGF receptor pair induced adhesion, proliferation, and differentiation of EPCs in vitro. VEGF-bound stents and artificial grafts generated EPC adhesion and colonization, followed by endothelialization on porcein model. Thus, our prototype surface architecture to propose new concept of providing nonthrambogenic potential on blood-contacting devices.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Reversible Hydrogel Formation Driven by Protein-Peptide-Specific Interaction and Chondrocyte Entrapment. Biomaterial.2010
Author(s)
Fuyu Ito, Kengo Usui, Daigo Kawahara, Atsushi Suenaga, Tei Maki, Satoru Kidoaki, Harukazu Suzuki, Makoto Taiji, Masayoshi Itoh, Yoshihide Hayashizaki, Takehisa Matsuda
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Journal Title
Biomaterial
Volume: 31(1)
Pages: 58-66
Related Report
Peer Reviewed
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