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Experimental evidence of in situ capture of endothelial progenitor cells on luminal surface of artificial grafts in bloodstream on porcein model.

Research Project

Project/Area Number 20300171
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKanazawa Institute of Technology

Principal Investigator

MATSUDA Takehisa  Kanazawa Institute of Technology, ゲノム生物工学研究所, 教授 (60142189)

Co-Investigator(Kenkyū-buntansha) WATANABE Go  金沢大学, 医学(系)研究科(研究院), 教授 (60242492)
OOTAKE Hiroshi  金沢大学, 医学(系)研究科(研究院), 特任教授 (60283131)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2008: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Keywords生体材料 / 細胞組織 / 人工血管 / 生体力学 / 動物実験 / 生物材料
Research Abstract

This study aims at in situ capture of endothelial progenitor cells (EPCs) on blood-contacting surfaces of cardiovascular devices in bloodstream. Among various cell surface receptor/legend pairs, only surface-bound VEGF/VEGF receptor pair induced adhesion, proliferation, and differentiation of EPCs in vitro. VEGF-bound stents and artificial grafts generated EPC adhesion and colonization, followed by endothelialization on porcein model. Thus, our prototype surface architecture to propose new concept of providing nonthrambogenic potential on blood-contacting devices.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (17 results)

All 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Luminal surface design of electrospun small-diameter graft aiming at in situ capture of endothelial progenitor cell.2010

    • Author(s)
      Miyazu K, Kawahara D, Ohtake H, Watanabe G, Matsuda T
    • Journal Title

      J.Biomed.Mater.Sci.

      Volume: 94B Pages: 53-63

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental use of an elastomeric surgical sealant for arterial hemostasis and its long-term tissue response.2010

    • Author(s)
      Oda S, Morita S, Tanoue Y, Eto M, Matsuda T, Tominaga R
    • Journal Title

      Interactive Cardio Vascular Thorac Surg.

      Volume: 10 Pages: 258-261

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reversible Hydrogel Formation Driven by Protein-Peptide-Specific Interaction and Chondrocyte Entrapment. Biomaterial.2010

    • Author(s)
      Fuyu Ito, Kengo Usui, Daigo Kawahara, Atsushi Suenaga, Tei Maki, Satoru Kidoaki, Harukazu Suzuki, Makoto Taiji, Masayoshi Itoh, Yoshihide Hayashizaki, Takehisa Matsuda
    • Journal Title

      Biomaterial

      Volume: 31(1) Pages: 58-66

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymerization of trimethylene carbonate in aqueous solutions : Reaction mechanism and characterization.2010

    • Author(s)
      Takao Okada, Yukari Imamura, Takehisa Matsuda
    • Journal Title

      Journal of Polymer Science : Part A : Polymer Chemistry

      Volume: 48(7) Pages: 1485-1492

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiscale fabrication of a transparent circulation type blood vessel simulator.2010

    • Author(s)
      Takuma Nakano, Taro Itoyama, Keisuke Yoshida, Yu Sawada, Seiichi Ikeda, Toshio Fukuda, Takehisa Matsuda, Makoto Negoro, Fumihito Arai
    • Journal Title

      American Institute of Physics

      Volume: 046505 Pages: 1-10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Luminal Surface Design of Electrospun Small-Diameter Graft Aiming at In Situ Capture of Endothelial Progenitor Cell2010

    • Author(s)
      K.Miyazu, D.Kawahara, H.Ohtake, G.Watanabe, T.Matsuda.
    • Journal Title

      J Biomed mater Res Part B (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cartilaginous tissue formation using a mechano-active scaffold and dynamic compressive stimulation.2008

    • Author(s)
      Y. Jung, SH. Kim, S-H. Kim, YH. Kim, J. Xie, T. Matsuda, BG. Min.
    • Journal Title

      J. Biomater. Sci. Polymer Edn. 19(1)

      Pages: 61-74

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of biodegradable scaffolds based on patient-spacific arterial configuration.2008

    • Author(s)
      T. Uchida, S. Ikeda, H. Oura, M. Tada, T. Nakano, T. Fukuda, T. Matsuda, M. Negoro, F. Arai.
    • Journal Title

      Jounal of Biotechnology. 133

      Pages: 213-218

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ harvesting of adhered target cells using thermoresponsive substrate under a microscope : Principle and instrumentation.2008

    • Author(s)
      H. Takamatsu, S. Uchida, T. Matsuda.
    • Journal Title

      Journal of Biotechnology. 134

      Pages: 297-304

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous Processing of Fibril Formation and Cross-Linking Improves Mechanical Properties of Collagen.2008

    • Author(s)
      S. Yunoki, T. Matsuda.
    • Journal Title

      Biomacro molecules Vol. 9

      Pages: 879-885

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibody-Bound Cell Microarray for Immunophenotyping : Surface Modification and Lymphocyte Subpopulations.2008

    • Author(s)
      Y. Fujii, J. M. Anderson, T. Matsuda.
    • Journal Title

      Journal of Biomedical Materials Research, Part B : Applied Biomaterials 87

      Pages: 525-537

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Instability of self-assembled monolayers as a model material system for macrophage/FBGC cellular behavior.2008

    • Author(s)
      J. A. Jones, L. A. Qin, H. Meyerson, I. K. Kwon, T. Matsuda, J. M. Anderson
    • Journal Title

      Journal of Biomedical Materials Research, Part A 86A(1)

      Pages: 261-268

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] International Review of Thrombosis.2008

    • Author(s)
      松田 武久
    • Journal Title

      人工臓器と血栓 Vol. 3

      Pages: 22-27

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 循環器系デバイスに用いるバイオマテリアル。2008

    • Author(s)
      松田 武久
    • Journal Title

      バイオマテリアル-生体材料- Vol. 26

      Pages: 157-158

    • NAID

      10021140744

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Robotics-based Fabrication of Vascular Graft.2009

    • Author(s)
      松田武久
    • Organizer
      The 2^<nd> World Congress of Tissue Engineering and Regenerative Medicine International Society
    • Place of Presentation
      Lotte Hotel World, Seoul, Republic of Korea
    • Year and Date
      2009-08-31
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 埋め込み部材2009

    • Inventor(s)
      松田武久
    • Industrial Property Rights Holder
      金沢工業大学
    • Filing Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 埋め込み部材2009

    • Inventor(s)
      松田武久
    • Industrial Property Rights Holder
      金沢工業大学
    • Filing Date
      2009-10-30
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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