Study of the minimally invasive proton therapy combined with anti-cancer drugs and vascular disrupting agents

• Project/Area Number: 20300174
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Tohoku University
• Principal Investigator: TERAKAWA Atsuki Tohoku University, 大学院・工学研究科, 准教授 (10250854)
• Co-Investigator(Kenkyū-buntansha): SAKEMI Yasuhiro 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (90251602) ; YAMAZAKI Hiromichi 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00166654) ; TASHIRO Manabu 東北大学, サイクロトロン・ラジオアイソトープセンター, 准教授 (00333477)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2008: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
• Keywords: 粒子線治療 / PET / 腫瘍血管標的薬剤 / 腫瘍血管標的薬 / 腫瘍増殖遅延 / 腫瘍血管標的 / 薬剤伝達 / 腫瘍血管 / マイクロパターンガス検出器 / 熱音響パルス

Research Abstract

The aim of this study was to develop combined treatments between proton therapy and chemotherapy using a vascular targeting agent or an anti-cancer drug which not only kill radio-resistant hypoxia tumor cells effectively but also reduce side effects. We used the novel vascular disrupting agent AVE8062 as a vascular targeting agent, while cisplatin was used as an anti-cancer drag. The results of the therapeutic experiments on a murine solid tumor showed that the proton therapy combined with AVE8062 or cisplatin inhibited tumor growth significantly in comparison to their monotherapies.

Research Products

• [Journal Article] PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin (2011)
  • Author(s): A.Terakawa, K.Ishii, H.Yamazaki, S.Matsuyama, Y.Kikuchi, Y.Ito, A.Tagawa, S.Yasunaga, T.Kawamura, Y.Takahashi, Y.Hatori, N.Hamada, K.Fujiki, N.Ito, S.Wada, Y.Funaki, K.Sera
  • Journal Title: X-RAY Spectrometry 巻未定、掲載確定
  • Peer Reviewed
• [Journal Article] PIXE analysis of a murine solid tumor treated with proton therapy com bined with cisplatin (2011)
  • Author(s): A.Terakawa
  • Journal Title: X-RAY Spectrometry Volume: 未定
  • Peer Reviewed
• [Journal Article] PIXE ANALYSIS OF A MURINE FIBROSARCOMA TUMOR FOR PROTON THERAPY COMBINED WITH THE CHEMOTHERAPEUTIC AGENT CISPLATIN (2010)
  • Author(s): A.TERAKAWA, Y.ITO, K.ISHII, S.MATSUYAMA, Y.KIKUCHI, S.YASUNAGA, A.TAGAWA, T.KAWAMURA, Y.TAKAHASHI, Y.HATORI, N.HAMADA, K.FUJIKI, H.YAMAZAKI, Y.FUNAKI, N.ITO, S.WADA, K.SERA
  • Journal Title: International Journal of PIXE Vol.20 3&4 Pages: 85-91
  • Peer Reviewed
• [Journal Article] Development of an adjustable beam flattening system for modification of passive beam delivery technique in proton therapy (2010)
  • Author(s): A.Esmaili Torshabi, A.Terakawa, K.Ishii, H.Yamazaki, S.Matsuyama, Y.Kikuchi, H.Akiyama, K.Koyata, A.Tagawa, Y.Itoh, S.Yasunaga
  • Journal Title: Nuclear Instruments and Methods in Physics Research、A 615 Pages: 138-141
  • Peer Reviewed
• [Journal Article] PIXE ANALYSIS OF A MURINE FIBROSARCOMA TUMOR FOR PRO TON THERAPY COMBINED WITH THE CHEMOTHERAPEUTIC AGE NT CISPLATIN (2010)
  • Author(s): A.Terakawa
  • Journal Title: International Journal of PIXE Volume: 20, No 3, 4 Pages: 85-91
  • Peer Reviewed
• [Journal Article] High-resolution [1SF]FDG-PET Measurement of a Murine Fibrosarcoma Treated With Proton Therapy Combined With the Vascular Disrupting Agent AVE8062 (2010)
  • Author(s): Terakawa A.
  • Journal Title: CYRIC ANNUAL REPORT Volume: 2009 Pages: 61-63
• [Journal Article] Development of an adjustable beam flattening system for modification of passive beam delivery technique in proton therapy (2010)
  • Author(s): A.Esmaili Torshabi
  • Journal Title: Nuclear Instruments and Methods in Physics Research A615 Pages: 183-141
  • Peer Reviewed
• [Journal Article] Tumor Growth Delay Caused by Proton Therapy in Combination with the Vascular Disrupting Agent AVE8062 (2010)
  • Author(s): Terakawa A.
  • Journal Title: CYRIC Annual Report 2008 Pages: 61-64
• [Journal Article] Development of a Multi-pattern Gas Detector for Beam Monitoring in Proton Therapy (2010)
  • Author(s): Terakawa A.
  • Journal Title: CYRIC Annual Report 2008 Pages: 65-68
• [Journal Article] Therapeutic efficacy of proton therapy combined with tumor blood flow interruption evaluated by high-resolution [^<18>F]FDG-PET (2009)
  • Author(s): A.Terakawa, K.Ishii, H.Yamazaki, Y.Funaki, M.Tashiro, S.Furumoto, S.Matsuyama, Y.Kikuchi, J.Arikawa, T.Togashi, W.Yamashita, H.Akiyama, H.Koyata, K.Nakazawa, Y.Itoh, A.Tagawa, S.Yasunaga, S.Wada, N.Itoh
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging 36(2)
  • Peer Reviewed
• [Journal Article] Therapeutic efficacy of proton therapy combined with tumor blood flow interruption evaluated by high-resolution [^<18>F]FDG-PET (2009)
  • Author(s): A.Terakawa
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging 36(2)
  • Peer Reviewed
• [Journal Article] Proton Therapy Facilities at CYRIC (2008)
  • Author(s): Atsuki TERAKAWA, Keizo ISHII, Toshiyuki CHIBA, Takuya MIYASHITA, Tatsuya YAMAMOTO, Jun ARIKAWA, Takanori TOGASHI, Wataru YAMASHITA, Hisaki AKIYAMA, Hiroshi KOYATA, Yuzo FUJITA, Azusa ISHIZAKI, Taizo HONDA, Yuuki TOTSUKA, Nobuhiko ITO, Tadashi SANO, Seiichi WADA
  • Journal Title: Tohoku University, Proceedings of the 16th Pacific Basin Nuclear Conference (16PBNC), Aomori, Japan, Oct.13-18, 2008
  • Peer Reviewed
• [Journal Article] Proton Therapy Facilities at CYRIC, Tohoku University (2008)
  • Author(s): A. Terakawa
  • Journal Title: Proceedings of the 16th Pacific Basin Nuclear Conference (16PBNC), Aomori, Japan, Oct. 13-18, 2008 1
  • Peer Reviewed
• [Journal Article] PIXE STUDY ON ABSORPTION OF ARSENATE AND ARSENITE BY ARSENIC HYPER ACCUMULATING FERN (2008)
  • Author(s): H. Yamazaki
  • Journal Title: International Journal of PIXE 18 Pages: 241-252
  • Peer Reviewed
• [Presentation] 腫瘍血管遮断剤AVE8062を投与したマウス固形腫瘍のPIXE分析 (2010)
  • Author(s): 寺川貴樹
  • Organizer: 第28回PIXEシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2010-11-18
• [Presentation] 腫瘍血管遮断剤AVE8062による陽子線治療の増感に関する基礎研究 (2010)
  • Author(s): 寺川貴樹
  • Organizer: (社)日本原子力学会
  • Place of Presentation: 札幌
  • Year and Date: 2010-09-16
• [Presentation] PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin (2010)
  • Author(s): 寺川貴樹
  • Organizer: 12th International Conference on Particle Induced X-ray Emission and its Analytical Applications
  • Place of Presentation: Guildford,イギリス
  • Year and Date: 2010-06-28
• [Presentation] PIXE analysis of a murine solid tumor treated with proton therapy com bined with cisplatin (2010)
  • Author(s): A.Terakawa
  • Organizer: 12th International Conference on Particle Induced X-ray Emission and its Analytical Applications
  • Place of Presentation: Guildford,イギリス
  • Year and Date: 2010-06-28
• [Presentation] 粒子線治療効果を上げるための抗がん剤のがん細胞への集積度の研究 (2009)
  • Author(s): 伊藤友紀
  • Organizer: 第26回 PIXEシンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2009-11-20
• [Presentation] Therapeutic efficacy of proton therapy combined with tumor blood flow interruption evaluated by high-resolution [^<18>F]FDG-PET (2009)
  • Author(s): 寺川貴樹
  • Organizer: ANNUAL CONGRESS OF THE EUROPEAN ASSOCIATION OF NUCLEAR MEDICINE
  • Place of Presentation: バルセロナ、スペイン
  • Year and Date: 2009-10-11
• [Presentation] 陽子線治療の現状 (2009)
  • Author(s): 寺川貴樹
  • Organizer: 日本原子力学会(招待講演)
  • Place of Presentation: 仙台
  • Year and Date: 2009-09-17
• [Presentation] 陽子線治療の現状 (2009)
  • Author(s): 寺川貴樹
  • Organizer: (社)日本原子力学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-09-17
• [Presentation] 陽子線治療における生物学的効果比に基づく拡大ブラッグピーク形成 (2009)
  • Author(s): 秋山久樹
  • Organizer: (社)日本原子力学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-09-16
• [Presentation] Proton Therapy Facilities at CYRIC (2008)
  • Author(s): 寺川貴樹
  • Organizer: Tohoku University, 16th Pacific Basin Nuclear Conference (16PBNC), Aomori, Japan, Oct.13-18, 2008
  • Place of Presentation: 青森
  • Year and Date: 2008-10-16
• [Presentation] 腫瘍血管遮断剤AVE8062を併用した陽子線照射の抗腫瘍効果に関する研究 (2008)
  • Author(s): 寺川貴樹
  • Organizer: 日本原子力学会
  • Place of Presentation: 高知
  • Year and Date: 2008-09-05
• [Presentation] 腫瘍血管遮断剤AVE8062を併用した陽子線照射の抗腫瘍効果に関する研究 (2008)
  • Author(s): 寺川貴樹
  • Organizer: (社)日本原子力学会
  • Place of Presentation: 高知工科大学
  • Year and Date: 2008-09-05
• [Presentation] 呼吸に同期した3次元走査による粒子線治療の精緻化 (2008)
  • Author(s): 富樫貴紀
  • Organizer: (社)日本原子力学会
  • Place of Presentation: 高知工科大学
  • Year and Date: 2008-09-05