Study of the minimally invasive proton therapy combined with anti-cancer drugs and vascular disrupting agents
| Project/Area Number |
20300174
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Tohoku University |
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Principal Investigator |
TERAKAWA Atsuki Tohoku University, 大学院・工学研究科, 准教授 (10250854)
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| Co-Investigator(Kenkyū-buntansha) |
SAKEMI Yasuhiro 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (90251602)
YAMAZAKI Hiromichi 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00166654)
TASHIRO Manabu 東北大学, サイクロトロン・ラジオアイソトープセンター, 准教授 (00333477)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Keywords | 粒子線治療 / PET / 腫瘍血管標的薬剤 / 腫瘍血管標的薬 / 腫瘍増殖遅延 / 腫瘍血管標的 / 薬剤伝達 / 腫瘍血管 / マイクロパターンガス検出器 / 熱音響パルス |
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| Research Abstract |
The aim of this study was to develop combined treatments between proton therapy and chemotherapy using a vascular targeting agent or an anti-cancer drug which not only kill radio-resistant hypoxia tumor cells effectively but also reduce side effects. We used the novel vascular disrupting agent AVE8062 as a vascular targeting agent, while cisplatin was used as an anti-cancer drag. The results of the therapeutic experiments on a murine solid tumor showed that the proton therapy combined with AVE8062 or cisplatin inhibited tumor growth significantly in comparison to their monotherapies.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin2011
Author(s)
A.Terakawa, K.Ishii, H.Yamazaki, S.Matsuyama, Y.Kikuchi, Y.Ito, A.Tagawa, S.Yasunaga, T.Kawamura, Y.Takahashi, Y.Hatori, N.Hamada, K.Fujiki, N.Ito, S.Wada, Y.Funaki, K.Sera
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Journal Title
X-RAY Spectrometry 巻未定、掲載確定
Related Report
Peer Reviewed
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[Journal Article] PIXE ANALYSIS OF A MURINE FIBROSARCOMA TUMOR FOR PROTON THERAPY COMBINED WITH THE CHEMOTHERAPEUTIC AGENT CISPLATIN2010
Author(s)
A.TERAKAWA, Y.ITO, K.ISHII, S.MATSUYAMA, Y.KIKUCHI, S.YASUNAGA, A.TAGAWA, T.KAWAMURA, Y.TAKAHASHI, Y.HATORI, N.HAMADA, K.FUJIKI, H.YAMAZAKI, Y.FUNAKI, N.ITO, S.WADA, K.SERA
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Journal Title
International Journal of PIXE Vol.20 3&4
Pages: 85-91
Related Report
Peer Reviewed
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[Journal Article] Development of an adjustable beam flattening system for modification of passive beam delivery technique in proton therapy2010
Author(s)
A.Esmaili Torshabi, A.Terakawa, K.Ishii, H.Yamazaki, S.Matsuyama, Y.Kikuchi, H.Akiyama, K.Koyata, A.Tagawa, Y.Itoh, S.Yasunaga
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Journal Title
Nuclear Instruments and Methods in Physics Research、A 615
Pages: 138-141
Related Report
Peer Reviewed
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[Journal Article] Therapeutic efficacy of proton therapy combined with tumor blood flow interruption evaluated by high-resolution [^<18>F]FDG-PET2009
Author(s)
A.Terakawa, K.Ishii, H.Yamazaki, Y.Funaki, M.Tashiro, S.Furumoto, S.Matsuyama, Y.Kikuchi, J.Arikawa, T.Togashi, W.Yamashita, H.Akiyama, H.Koyata, K.Nakazawa, Y.Itoh, A.Tagawa, S.Yasunaga, S.Wada, N.Itoh
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Journal Title
European Journal of Nuclear Medicine and Molecular Imaging 36(2)
Related Report
Peer Reviewed
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[Journal Article] Proton Therapy Facilities at CYRIC2008
Author(s)
Atsuki TERAKAWA, Keizo ISHII, Toshiyuki CHIBA, Takuya MIYASHITA, Tatsuya YAMAMOTO, Jun ARIKAWA, Takanori TOGASHI, Wataru YAMASHITA, Hisaki AKIYAMA, Hiroshi KOYATA, Yuzo FUJITA, Azusa ISHIZAKI, Taizo HONDA, Yuuki TOTSUKA, Nobuhiko ITO, Tadashi SANO, Seiichi WADA
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Journal Title
Tohoku University, Proceedings of the 16th Pacific Basin Nuclear Conference (16PBNC), Aomori, Japan, Oct.13-18, 2008
Related Report
Peer Reviewed
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