Basic research for renal rehabilitation : Clarification of mechanism of cardiovascular disease prevention
Project/Area Number |
20300184
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KANAZAWA Masayuki 東北大学, 大学院・医学系研究科, 非常勤講 (60282050)
ITO Osamu 東北大学, 大学院・医学系研究科, 准教授 (00361072)
佐藤 寿伸 東北大学, 病院, 准教授 (50312583)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
Keywords | リハビリテーション医学 / 腎臓リハビリテーション / 慢性腎不全モデルラット / 長期的運動 / インスリン感受性 / 心血管系合併症 / 高血圧 |
Research Abstract |
In rats with chronic renal faikure, chronic exercise improved insulin sensitivity. The combination therapy with chronic exercise, angiotensin II receptor blocker and branched chain-amino acids improved blood pressure, renal protection, and capillary density and type I muscle fiber type in skeletal muscles. The combination therapy with chronic exercise and N + L type calcium channel blocker, cilnidipine improved blood pressure, renal protection and insulin sensitivity. These effects of chronic exercise and cilnidipine may be mediated by an inhibition of sympathetic nervous system.
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Report
(4 results)
Research Products
(87 results)
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[Journal Article] Expression of kisspeptins and kisspeptin receptor in the kidney of chronic renal failure rats2010
Author(s)
Shoji I, Hirose T, Mori N, Hiraishi K, Kato I, Shibasaki A, Yamamoto H, Ohba K, Kaneko K, Morimoto R, Satoh F, Kohzuki M, Totsune K, Takahashi K
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Journal Title
Peptides
Volume: 31
Pages: 1920-5
Related Report
Peer Reviewed
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[Journal Article] Expression of adrenomedullin 2/intermedin, a possible Reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure2010
Author(s)
Hirose T, Totsune K, Mori N, Mori T, Morimoto R, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y
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Journal Title
Am J Physiol Renal Physiol
Volume: 299
Related Report
Peer Reviewed
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[Journal Article] Increased expression of (prorenin receptor in the remnant kidneys of 5/6 nephrectomized rats2010
Author(s)
Hirose T, Mori N, Totsune K, Morimoto R, Maejima T, Kawamura T, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y
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Journal Title
Regul Pept
Volume: 159
Pages: 93-99
Related Report
Peer Reviewed
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[Journal Article] Increased expression of (pro) renin receptor in the remnant kidneys of 5/6 nephrectomized rats2010
Author(s)
Hirose T, Mori N, Totsune K, Morimoto R, Maejima T, Kawamura T, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y
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Journal Title
Regul Pept
Volume: 159
Pages: 93-99
Related Report
Peer Reviewed
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[Journal Article] Expression of adrenomedullin 2/intermedin, a possible reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure2010
Author(s)
Hirose T, Totsune K, Mori N, Mori T, Morimoto R, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y
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Journal Title
Am J Physiol Renal Physiol
Volume: 299
Related Report
Peer Reviewed
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[Journal Article] 厚生労働省循環器病研究委託費(15指-2)「わが国における心疾患リハビリテーションの実態調査と普及促進に関する研究」班2009
Author(s)
上月正博, 齋藤宗靖, 岩坂壽二, 代田浩之, 上嶋健治, 牧田茂, 安達仁, 横井宏佳, 大宮一人, 三河内弘, 横山広行, 後藤葉一
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Journal Title
わが国における心臓リハビリテーションの採算性多施設調査結果
Volume: 4
Pages: 269-275
Related Report
Peer Reviewed
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[Journal Article] Gene expression of(pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure2009
Author(s)
Hirose T, Mori N, Totsune K, Morimoto R, Maejima T, Kawamura T, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y.
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Journal Title
Peptides 30
Pages: 2316-2322
Related Report
Peer Reviewed
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[Journal Article] Effect of radiation monitoring method and formula differences on estimated physician dose during percutaneous coronary intervention.2009
Author(s)
Chida K, Morishima Y, Masuyama H, Chiba H, Katahira Y, Inaba Y, Mori I, Maruoka S, Takahashi S, Kohzuki M, Zuguchi M.
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Journal Title
Acta Radiol 50
Pages: 170-173
Related Report
Peer Reviewed
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[Presentation] Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure2010
Author(s)
Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Kohzuki M
Organizer
6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
Place of Presentation
Kyoto
Year and Date
2010-06-18
Related Report
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[Presentation] Effect of combination therapy of chronic exercise, anti-hypertensive drugs on systolic blood pressure, renal function, exercise endurance and skeletal capillaries in a rat model of chronic renal failure2008
Author(s)
Ishida A, Kanazawa M, Lu H, Kawamura T, Ito D, Ito O, Ootaka T, Sato T, Kohzuki M
Organizer
22nd Scientific Meeting of International Society of Hypertension
Place of Presentation
Berlin
Year and Date
2008-06-15
Related Report
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[Presentation] 慢性腎不全モデルラットにおける長期的運動, bCAAと降圧薬による血圧, 腎と骨格筋に対する併用効果.2008
Author(s)
金澤雅之, 姚強, 須田千尋, 室谷嘉一, 森信芳, 長坂誠, 伊藤修, 黒澤一, 上月正博
Organizer
第45回日本リハビリテーション医学会
Place of Presentation
横浜
Year and Date
2008-06-05
Related Report
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