| Project/Area Number |
20300184
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAZAWA Masayuki 東北大学, 大学院・医学系研究科, 非常勤講 (60282050)
ITO Osamu 東北大学, 大学院・医学系研究科, 准教授 (00361072)
佐藤 寿伸 東北大学, 病院, 准教授 (50312583)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | リハビリテーション医学 / 腎臓リハビリテーション / 慢性腎不全モデルラット / 長期的運動 / インスリン感受性 / 心血管系合併症 / 高血圧 |
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| Research Abstract |
In rats with chronic renal faikure, chronic exercise improved insulin sensitivity. The combination therapy with chronic exercise, angiotensin II receptor blocker and branched chain-amino acids improved blood pressure, renal protection, and capillary density and type I muscle fiber type in skeletal muscles. The combination therapy with chronic exercise and N + L type calcium channel blocker, cilnidipine improved blood pressure, renal protection and insulin sensitivity. These effects of chronic exercise and cilnidipine may be mediated by an inhibition of sympathetic nervous system.
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