• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The optimum intensity of exercise to enhance adult hippocampal neurogenesis : The role of glucocorticoid (corticosterone)

Research Project

Project/Area Number 20300214
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionUniversity of Tsukuba

Principal Investigator

SOYA Hideaki  University of Tsukuba, 大学院・人間総合科学研究科, 教授 (50221346)

Co-Investigator(Kenkyū-buntansha) ASADA Takashi  筑波大学, 大学院・人間総合科学研究科, 教授 (90184142)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords軽運動 / 成熟海馬 / 神経新生 / ストレス / 走運動 / 幼若神経 / 認知機能 / 乳酸閾値 / グルココルチコイド受容体 / ミネラルコルチコイド受容体 / コルチコステロン / 乳酸性作業閾値 / 幼弱神経
Research Abstract

A low intensity exercise without stress enhanced adult hippocampus neurogenesis (AHN), while the effect disappeared by a high intensity exercise with stress. Furthermore, it became clear that low intensity exercise induced AHN via corticosterone (CORT) pathway and found that inhibitory effect of glucocorticoid receptor (GR) became dominant in the high intensity exercise. It was suggested that CORT took an important role in specific effect of exercise intensities on hippocampal plasticity.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (53 results)

All 2010 2009 2008

All Journal Article (17 results) (of which Peer Reviewed: 4 results) Presentation (33 results) Book (3 results)

  • [Journal Article] Brain Activation Through Exercise : Study on exercise conditions which lead to neuronal activation and hippocampal neurogenesis2010

    • Author(s)
      Soya H, Okamoto M, Matsui T, Lee M, Inoue K, Nishikawa S, Soya S, Fujikawa T, Chang H, Nishijima T
    • Journal Title

      Journal of Exercise Nutrition and Biochemistry 60

      Pages: 794-796

    • Related Report
      2010 Final Research Report
  • [Journal Article] Brain activation through exercise : study on exercise conditions which leads to neuronal activation and hippocampal neurogenesis2010

    • Author(s)
      Soya H, Okamoto M, Matsui T, Lee M, Inoue K, Soya S, Nishikawa S, Fujikawa T, Chang H, Nishijima T
    • Journal Title

      International Sport Science Congress : Sport and Identity in a Multicultural Society

      Pages: 188-198

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS2010

    • Author(s)
      Nishijima T, Piriz J, Duflos S, Fernandez AM, Gaitan G, Gomez-Pinedo U, Verdugo JM, Leroy F, Soya H, Nunez A, Torres-Aleman I
    • Journal Title

      Neuron 67

      Pages: 834-846

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS2010

    • Author(s)
      Nishijima T, Piriz J, Duflos S, Fernandez AM, Gaitan G, Gomez-Pinedo U, Verdugo JM, Leroy F, Soya H, Nunez A, Torres-Aleman I
    • Journal Title

      Neuron

      Volume: 67 Pages: 834-846

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain activation through exerciseatudy on exercise conditions which leads to neuronal activation and hippocampal neurogenesis2010

    • Author(s)
      Soya H, Okamoto M, Matsui T, Lee M, lnoue K, Soya S, Nishikawa S, Fujikawa T, Chang H, Nishijima T
    • Journal Title

      International Sport Science Congress:Sport and Identity in a Multicultural Society

      Pages: 188-198

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain Activation Through Exercise:Study on exercise conditions which lead to neuronal activation and hippocampal neurogenesis2010

    • Author(s)
      Hideaki Soya, Masahiro Okamoto, Takashi Matsui, Minchul Lee, Koshiro Inouel, Shimpei Nishikawal Shingo Soya, Takahiko Fujikawa, Hyukki Chang, Takeshi Nishijima
    • Journal Title

      Journal of Exercise Nutrition and Biochemistry

      Volume: 60 Pages: 794-796

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 運動により脳をエイジングから守る2009

    • Author(s)
      征矢英昭、岡本正洋、井上恒志郎
    • Journal Title

      ANTI-AGING MEDICINE 6

      Pages: 40-44

    • Related Report
      2010 Final Research Report
  • [Journal Article] 脳に豊かさを与えるスポーツ・運動の意義-海馬の可塑性を高める運動効果から-2009

    • Author(s)
      征矢英昭
    • Journal Title

      体育の科学 59

      Pages: 749-758

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] 脳を活性化させる運動-海馬の可塑性を高める運動条件の探索-2009

    • Author(s)
      山村侑平、征矢英昭
    • Journal Title

      体育の科学 59

      Pages: 189-197

    • Related Report
      2010 Final Research Report
  • [Journal Article] 脳を活性化させる運動-海馬の可塑性を高める運動条件の探索-2009

    • Author(s)
      山村侑平, 征矢英昭
    • Journal Title

      体育の科学 59

      Pages: 189-197

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 運動により脳をエイジングから守る2009

    • Author(s)
      征矢英昭, 岡本正洋, 井上恒志郎
    • Journal Title

      ANTI-AGING MEDICINE 59

      Pages: 749-758

    • Related Report
      2009 Annual Research Report
  • [Journal Article] アーリーライフステージの運動と海馬の発達・社会ストレスの影響2008

    • Author(s)
      岡本正洋、征矢英昭
    • Journal Title

      子どもの発育発達 5

      Pages: 212-216

    • Related Report
      2010 Final Research Report
  • [Journal Article] 環境と神経新生2008

    • Author(s)
      山村侑平、征矢英昭
    • Journal Title

      ClinicalNeuroscience 26

      Pages: 912-914

    • Related Report
      2010 Final Research Report
  • [Journal Article] 第7章,海馬の可塑性を高める運動効果と分子機構.特集、分子メカニズムから考えるスポーツ効果:生活習慣病と関連して2008

    • Author(s)
      征矢英昭
    • Journal Title

      臨床スポーツ医学 10

      Pages: 1175-1180

    • Related Report
      2010 Final Research Report
  • [Journal Article] 第7章, 海馬の可塑性を高める運動効果と分子機構.特集,分子メカニズムから考えるスポーツ効果:生活習慣病と関連して.2008

    • Author(s)
      征矢英昭
    • Journal Title

      臨床スポーツ医学 10

      Pages: 1175-1180

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 環境と神経新生2008

    • Author(s)
      山村侑平,征矢英昭
    • Journal Title

      Clinical Neuroscience 26

      Pages: 912-914

    • Related Report
      2008 Annual Research Report
  • [Journal Article] アーリーライフステージの運動と海馬の発達・社会ストレスの影響.2008

    • Author(s)
      岡本正洋,征矢英昭
    • Journal Title

      子どもの発育発達 5

      Pages: 212-216

    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム:軽運動による脳の活性化と可塑性2010

    • Author(s)
      征矢英昭
    • Organizer
      同志社大学スポーツ健康科学会(招待講演)
    • Place of Presentation
      同志社大学,京都
    • Year and Date
      2010-11-23
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム:軽運動による脳の活性化と可塑性2010

    • Author(s)
      征矢英昭
    • Organizer
      同志社大学スポーツ健康科学会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2010-11-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Blockade of androgen receptors inhibits treadmill running-induced adult hippocampal neurogenesis2010

    • Author(s)
      Okamoto M, Inoue K, Matsui T, Lee M, Soya H
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Delineation of the molecular profile of the effects of intense exercise training on neurogenesis2010

    • Author(s)
      Inoue K, Rakwal R, Lee M, Okamoto M, Soya H
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Loaded wheel running enhance BDNF function in the rat hippocampus2010

    • Author(s)
      Minchul L, Nogami H, Inoue K, Okamoto M, Matsui T, Soya H
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Loaded wheel running enhance BDNF function in the rat hippocampus.2010

    • Author(s)
      Minchul L, Nogami H, Inoue K, Okamoto M, Matsui T, Soya H
    • Organizer
      Neuroscierce
    • Place of Presentation
      San Diega, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Delineation of the molecular profile of the effects of intense exercise training on neurogenesis.2010

    • Author(s)
      noue K, Rakwal R, Lee M, Okamoto M, Soya H
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Blockade of androgen receptors inhibits treadmill running-induced adult hippocampal neurogenesis.2010

    • Author(s)
      Okamoto M, Inoue K, Matsui T, Lee M, Soya H
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床スポーツ医学会:教育講演(2)「脳を鍛える運動効果とホルモン」2010

    • Author(s)
      征矢英昭
    • Organizer
      日本臨床スポーツ医学会(招待講演)
    • Place of Presentation
      エポカル,つくば
    • Year and Date
      2010-11-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 臨床スポーツ医学会:教育講演(2)「脳を鍛える運動効果とホルモン」2010

    • Author(s)
      征矢英昭
    • Organizer
      日本臨床スポーツ医学会
    • Place of Presentation
      つくば(招待講演)
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム:運動と脳のメカニズムのサイエンス2010

    • Author(s)
      征矢英昭
    • Organizer
      第10回抗加齢学の実際、抗加齢学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-09-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム:運動で高めるメンタルヘルスと脳機能。メンタルヘルスを高める運動と脳機能海馬の可塑性と軽運動2010

    • Author(s)
      征矢英昭
    • Organizer
      日本体力医学会第65回大会(招待講演)
    • Place of Presentation
      和洋女子大学,千葉
    • Year and Date
      2010-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム:運動で高めるメンタルヘルスと脳機能。メンタルヘルスを高める運動と脳機能海馬の可塑性と軽運動2010

    • Author(s)
      征矢英昭
    • Organizer
      日本体力医学会第65回大会
    • Place of Presentation
      千葉(招待講演)
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低強度運動による海馬神経新生の促進効果を担う副腎皮質ホルモン:異的受容体拮抗薬を用いた検討2010

    • Author(s)
      征矢英昭、山村侑平、松井崇
    • Organizer
      日本体力医学会第65回大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 負荷付き自発運動は海馬BDNFの作用を高めるか2010

    • Author(s)
      イミンチョル、井上恒志郎、岡本正洋、松井崇、征矢英昭
    • Organizer
      日本体力医学会第65回大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 海馬機能を向上する低強度走運動トレーごングは海馬神経新生を促進するか2010

    • Author(s)
      井上恒志郎、岡本正洋、イミンチョル、松井崇、征矢英昭
    • Organizer
      日本体力医学会第65回大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 走運動で増加する成体海馬神経新生はフルタミド(アンドロゲン受容体拮抗薬)により抑制される2010

    • Author(s)
      岡本正洋、井上恒志郎、松井崇、イミンチョル、征矢英昭
    • Organizer
      日本神経科学学会第33回大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Brain Activation Through Exercise : Study on exercise conditions which lead to neuronal activation and plastic change in the hippocampus2010

    • Author(s)
      征矢英昭
    • Organizer
      International Sports Science Congree(招待講演)
    • Place of Presentation
      Chuncheon, Korea
    • Year and Date
      2010-08-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Brain Activation Through Exercise:Study on exercise conditions which lead to neuronal activation and plastic change in thehippocampus.2010

    • Author(s)
      Soya H
    • Organizer
      International Sports Science Congree
    • Place of Presentation
      Chuncheon, Korea(招待講演)
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of acute loaded wheel running on BDNF expression in the rat hippocampus.2010

    • Author(s)
      Lee MC, Soya H
    • Organizer
      International Sports Science Congree
    • Place of Presentation
      Chuncheon, Korea
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム:低強度運動による認知機能改善効果を担う分子機構:運動とアンチエイジング、基礎:運動による身心への有益な効果2010

    • Author(s)
      征矢英昭
    • Organizer
      シンポジウム3,第10回日本抗加齢医学会総会
    • Place of Presentation
      国立京都国際会館,京都
    • Year and Date
      2010-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム:低強度運動による認知機能改善効果を担う分子機構:運動とアンチエイジング、基礎:運動による身心への有益な効果、シンポジウム32010

    • Author(s)
      征矢英昭
    • Organizer
      第10回日本抗加齢医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 楽しい軽運動で高める脳フィットネス:気分を肇える運動処方の提案、運動とアンチエージング:最新エビデンス2010

    • Author(s)
      征矢英昭
    • Organizer
      第10回日本抗加齢医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 運動に伴うストレスが成体海馬神経新生に及ぼす影響:副腎皮質ホルモンの役割2009

    • Author(s)
      山村侑平, 岡本正洋, 井上恒志郎, 征矢英昭
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 認知機能を高める低強度運動トレーニング効果の脳内分子機構:TTRの同定2009

    • Author(s)
      井上恒志郎, 征矢英昭
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 異なった強度の走運動トレーニングが海馬の遺伝子発現に与える影響の検討2009

    • Author(s)
      井上恒志郎, 征矢英昭
    • Organizer
      日本体育学会第60回記念大会
    • Place of Presentation
      広島
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chronic Mild intensity running exercise leads increases dentate gyrus volume in the hippocampus2009

    • Author(s)
      Yamamura Y, Nishijima T, Deocaris CC, Okamoto M, Soya H
    • Organizer
      The 36th International Congress of Physiological Sciences, Kyoto, Japan, 2009.
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Would mild exercise be beneficial for hippocampal functions?, Strategies to reduce risks on the brain development contingent to urbanization2008

    • Author(s)
      Soya H, Okamoto M, Yamamura Y, Deocaris CC
    • Organizer
      Japan/China Symposium 2008
    • Place of Presentation
      University of Tsukuba, Tsukuba
    • Year and Date
      2008-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Would mild exercise be beneficial for hippocampal functions?2008

    • Author(s)
      Soya H, Okamoto M, Yamamura Y, Deocaris CC
    • Organizer
      Strategies to reduce risks on the brain development contingent to urbanization, Japan/China Symposium 2008
    • Place of Presentation
      Tsukuba
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 長期にわたる低強度走運動トレーニングは海馬歯状回を肥大させる.2008

    • Author(s)
      山村侑平,西島壮,Deocaris CC,岡本正洋,征矢英昭
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      大分
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 認知機能を高める運動適応に関連した分子ネットワークの理解:システム生物学の応用2008

    • Author(s)
      Deocaris CC,Rakwal R,山村侑平,平野美里,柴藤淳子,岡本正洋,西島壮,増尾好則,征矢英昭
    • Organizer
      第63回日本体力医学会大会
    • Place of Presentation
      大分
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 海馬の活性と可塑性を高める運動強度と分子機構2008

    • Author(s)
      征矢英昭
    • Organizer
      シンポジウム:運動はメンタルヘルスの維持改善に有効か,第143回日本体力医学会関東地方会
    • Place of Presentation
      明治安田生命4F,東京
    • Year and Date
      2008-07-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 海馬の活性と可塑性を高める運動強度と分子機構,シンポジウム:運動はメンタルヘルスの維持改善に有効か.2008

    • Author(s)
      征矢英昭
    • Organizer
      第143回日本体力医学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Book] 身体トレーニング:運動生理学からみた身体機能の維持・向上,海馬2009

    • Author(s)
      岡本正洋, 征矢英昭
    • Publisher
      真興交易
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Book] アンチエイジングの医学と臨床改訂2版(認知機能のアンチエイジング:運動、脳とアンチエージング(抗加齢)医学、II)(日本抗加齢医学会編)2008

    • Author(s)
      井上恒志郎、征矢英昭
    • Publisher
      Medical View
    • Related Report
      2010 Final Research Report
  • [Book] 認知機能のアンチエイジング:運動、脳とアンチエージング(抗加齢)医学、IIアンチエイジングの医学と臨床改訂2版、日本抗加齢医学会編2008

    • Author(s)
      井上恒史郎,征矢英昭
    • Total Pages
      3
    • Publisher
      Medical View
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi