The optimum intensity of exercise to enhance adult hippocampal neurogenesis : The role of glucocorticoid (corticosterone)
| Project/Area Number |
20300214
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SOYA Hideaki University of Tsukuba, 大学院・人間総合科学研究科, 教授 (50221346)
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| Co-Investigator(Kenkyū-buntansha) |
ASADA Takashi 筑波大学, 大学院・人間総合科学研究科, 教授 (90184142)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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|---|
| Keywords | 軽運動 / 成熟海馬 / 神経新生 / ストレス / 走運動 / 幼若神経 / 認知機能 / 乳酸閾値 / グルココルチコイド受容体 / ミネラルコルチコイド受容体 / コルチコステロン / 乳酸性作業閾値 / 幼弱神経 |
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| Research Abstract |
A low intensity exercise without stress enhanced adult hippocampus neurogenesis (AHN), while the effect disappeared by a high intensity exercise with stress. Furthermore, it became clear that low intensity exercise induced AHN via corticosterone (CORT) pathway and found that inhibitory effect of glucocorticoid receptor (GR) became dominant in the high intensity exercise. It was suggested that CORT took an important role in specific effect of exercise intensities on hippocampal plasticity.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS2010
Author(s)
Nishijima T, Piriz J, Duflos S, Fernandez AM, Gaitan G, Gomez-Pinedo U, Verdugo JM, Leroy F, Soya H, Nunez A, Torres-Aleman I
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS2010
Author(s)
Nishijima T, Piriz J, Duflos S, Fernandez AM, Gaitan G, Gomez-Pinedo U, Verdugo JM, Leroy F, Soya H, Nunez A, Torres-Aleman I
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Journal Title
Neuron
Volume: 67
Pages: 834-846
Related Report
Peer Reviewed
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