Long-term follow-up population study of rural residents for prediction and prophylaxis of life-style related diseases
| Project/Area Number |
20300220
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Shimane University |
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Principal Investigator |
YAMAGUCHI Syuhei (2010) Shimane University, 医学部, 教授 (80135904)
益田 順一 (2008-2009) Shimane University, 医学部, 教授 (70173747)
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| Co-Investigator(Kenkyū-buntansha) |
MASUDA Junichi 島根大学, 医学部, 教授 (70173747)
NABIKA Toru 島根大学, 医学部, 教授 (50180534)
SHIWAKU Kuninori 島根大学, 医学部, 教授 (10108384)
山口 修平 島根大学, 医学部, 教授 (80135904)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 保健健康管理 / 遺伝子多型 / コホート / ソーシャルキャピタル / 横断研究 / 生活習慣病 / 健康調査 / メタボリック症候群 / 遺伝子多型解析 / 食事習慣 / 生活満足度 / 認知機能 / 危険因子 / 疫学 / 肥満 / 頸動脈エコー |
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| Research Abstract |
In this study, we performed health examinations in a rural area, in which effects of single-nucleotide polymorphisms (SNPs) and social capital on life-style associated diseases were evaluated. We established a large cohort of 4000 participants with several valuable phenotypes for a future longitudinal study. In addition, we found unique relationships between social capital and hypertension as well as between combinations of multiple SNPs and oxidative stress.
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Report
(4 results)
Research Products
(82 results)
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[Journal Article] Confirmation of ALDH2 as a Major Locus of Drinking Behavior and of Its Variants Regulating Multiple Metabolic Phenotypes in a Japanese Population.2011
Author(s)
Takeuchi F, Isono M, Nabika T, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Ogihara T, Yamori Y, Fujioka A, Kato N
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Journal Title
Circ J.Epub ahead of print
Related Report
Peer Reviewed
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[Journal Article] Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals.2011
Author(s)
Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, Fujioka A, Isono M, Ohnaka K, Fujisawa T, Nakashima E, Ikegami H, Nakamura J, Yamori Y, Yamaguchi S, Kobayashi S, Ogihara T, Takayanagi R, Kato N
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Journal Title
Diabetologia Epub ahead of print
Related Report
Peer Reviewed
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[Journal Article] Blood pressure and hypertension are associated with 7 loci in the Japanese population.2010
Author(s)
Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N
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Journal Title
Circulation 53
Pages: 2302-2309
Related Report
Peer Reviewed
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[Journal Article] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.2010
Author(s)
Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, Serizawa M, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Nabika T, Kasturiratne A, Yamaguchi S, Kono S, Takayanagi R, Yamori Y, Kobayashi S, Ogihara T, de Silva A, Wickremasinghe R, Kato N
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Journal Title
Diabetologia 53
Pages: 299-308
Related Report
Peer Reviewed
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[Presentation] 日本人において7つの新規遺伝子座が血圧値および高血圧と関連している2010
Author(s)
竹内史比古, 勝谷友宏, 山本健, 横田充弘, 杉山卓郎, 並河徹, 藤岡晨宏, 大中佳三, 浅野展行, 家森幸男, 山口修平, 小林祥泰, 高柳涼一, 萩原俊男, 加藤規弘
Organizer
第33回日本高血圧学会総会
Place of Presentation
福岡
Year and Date
2010-10-15
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[Presentation] 脳卒中モデル動物の骨髄間葉系幹細胞移植による症状改善因子の検討2009
Author(s)
長井篤, 若林規良, Sheikh AM, 渡邊達三, 塩田由利, 三瀧真悟, Narantuya D, 益田順一, 小林祥泰, 山口修平
Organizer
Stroke2009(第34回日本脳卒中学会,第38回日本脳卒中の外科学会,第25回スパズム・シンポジウム)
Place of Presentation
松江
Related Report
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