| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Research Abstract |
To clarify whether the deregulation of circadian rhythm is involved in cancer, DMBA (7,12-dimethylbenz[a]anthracene) treated mice of 4 or 5 days old were kept in the completely dark condition during day and night (Dark and Dark, DD) or in 12 h-light and 12 h-dark condition (Light and Dark, LD). After 30 weeks, mice were sacrificed, and the spectrum and the number of tumors were analyzed. Mice kept in DD condition developed significantly more lung tumors (3.9 fold more lung tumors in male mice and 2.1 fold more lung tumors in female mice). As a next step, the molecular mechanisms of how deregulation of circadian rhythm promotes lung tumors will be elucidated.
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