Development toward preventive application of molecular hydrogen with a novel concept for lifestyle-related diseases
| Project/Area Number |
20300230
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
OHTA Shigeo Nippon Medical School, 大学院・医学研究科, 教授 (00125832)
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| Co-Investigator(Renkei-kenkyūsha) |
OHSAWA Ikuroh 東京都健康長寿医療センター研究所, 老化制御研究チーム, 研究副部長 (30343586)
KAMIMURA Naomi 日本医科大学, 老人病研究所, 講師 (60283800)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 水素 / 抗酸化物質 / 酸化ストレス / ミトコンドリア / 生活習慣病 |
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| Research Abstract |
Persistent oxidative stress is one of the major causes of most lifestyle-related diseases, cancer and the aging process. We have proposed that molecular hydrogen (H2) has potential as a "novel" antioxidant in preventive and therapeutic applications [Ohsawa et al., Nat Med. 2007 : 13 ; 688-94]. H2 has a number of advantages as a potential antioxidant : H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effects of consuming H2. There are several methods to ingest or consume H2, including drinking H2-dissolved water (hydrogen water). In this study, we have shown that model mice for dementia, diabetes, and arteriosclerosis were improved by drinking hydrogen
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Report
(4 results)
Research Products
(86 results)
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[Journal Article] Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart.2009
Author(s)
Endo J., Sano M., Katayama T., Hishiki T., Shinmura K., Morizane S., Matsuhashi T., Katsumata Y., Zhang Y., Ito H., Nagahata Y., Marchitti S., Nishimaki K., Wolf AM., Nakanishi H., Hattori F., Vasiliou V., Adachi T., Ohsawa I., Taguchi R., Hirabayashi Y., Ohta S., Suematsu M., Ogawa S., Fukuda K.
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Journal Title
Circ Res. 105(11)
Pages: 1118-1127
Related Report
Peer Reviewed
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[Journal Article] Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.2009
Author(s)
Fu Y., Ito M., Fujita Y., Ito M., Ichihara M., Masuda A., Suzuki Y., Maesawa S., Kajita Y., Hirayama M., Ohsawa I., Ohta S., Ohno K.
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Journal Title
Neurosci.Lett. 453(2)
Pages: 81-85
Related Report
Peer Reviewed
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[Journal Article] Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model.2008
Author(s)
Cai J., Kang Z., Liu WW., Luo X., Qiang S., Zhang JH., Ohta S., Sun X., Xu W., Tao H., Li R.
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Journal Title
Neurosci.Lett. 441(2)
Pages: 167-172
Related Report
Peer Reviewed
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[Journal Article] Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury.2008
Author(s)
Hayashida K., Sano M., Ohsawa I., Shinmura K., Tamaki K., Kimura K., Endo J., Katayama T., Kawamura A., Kohsaka S., Makino S., Ohta S., Ogawa S., Fukuda K.
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Journal Title
Biochem.Biophys.Res.Commun. 373(1)
Pages: 30-35
Related Report
Peer Reviewed
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