| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Research Abstract |
We investigated the effects of dietary antioxidants, such as polyphenols, carotenoids, vitamin C and vitamin E, on endothelial dysfunction, macrophage activation, and adipocyte differentiation. Dietary antioxidants decreased reactive oxygen species production, inflammatory cytokines expression and monocyte adhesion in endothelial cells. They inhibited MMP secretion, scavenger receptors expression and foam cell formation and also suppressed adipocyte differentiation. These results showed the pleiotropic effects of dietary antioxidants against atherosclerosis progression beyond their antioxidative potency.
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