Pleiotropic effects of dietary antioxidants against atherosclerosis progression
| Project/Area Number |
20300244
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Ochanomizu University |
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Principal Investigator |
KONDO Kazuo Ochanomizu University, 大学院・人間文化創成科学研究科, 教授 (30153711)
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| Co-Investigator(Renkei-kenkyūsha) |
TANI Mariko お茶の水女子大学, 生活環境教育研究センター, 研究機関研究員 (90452028)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 動脈硬化 / 抗酸化 / 血管内皮 / 脂肪細胞 / 抗酸化物質 / ポリフェノール / 血管内皮機能 / 単球活性化 / カロテノイド / マクロファージ / 血管内皮細胞 / 果実 |
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| Research Abstract |
We investigated the effects of dietary antioxidants, such as polyphenols, carotenoids, vitamin C and vitamin E, on endothelial dysfunction, macrophage activation, and adipocyte differentiation. Dietary antioxidants decreased reactive oxygen species production, inflammatory cytokines expression and monocyte adhesion in endothelial cells. They inhibited MMP secretion, scavenger receptors expression and foam cell formation and also suppressed adipocyte differentiation. These results showed the pleiotropic effects of dietary antioxidants against atherosclerosis progression beyond their antioxidative potency.
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Report
(4 results)
Research Products
(200 results)
