Budget Amount *help |
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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Research Abstract |
DNA lesions produced by ionizing radiation and environmental mutagen inhibit DNA replication. Stalling replication would lead to cell death if it persisted. Cells have mechanisms (post-replication repair, PRR) to restore DNA replication to survive against DNA-damaging agents. PRR is involved in induced mutagenesis. In this study, we purifiedenzymes required for PRR, reconstituted biochemical reactions with the enzymes and analyzed molecular mechanisms of the PRR.
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