Mechanism of Ionizing Radiation Induced Modulation of the Salt Chemotaxis Learning in C. elegans
| Project/Area Number |
20310032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
SAKASHITA Tetsuya 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究主幹 (30311377)
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Naoaki 東海大学, 医学部, 教授 (60096196)
YANASE Sumino 大東文化大学, スポーツ健康科学部, 准教授 (90249061)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Michiyo 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究員 (10507437)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 放射線 / 神経科学 / バイオセンサー / システムズ放射線生物学 / 酸化ストレス / システムバイオロジー / 応答 / システムズバイオロジー |
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| Research Abstract |
We developed a new chemotaxis population assay system with a broad NaCl concentration range from 1 to 100 mM. Using this assay system, we found that odr-3 gene was responsible for ionizing radiation induced modulation of the salt chemotaxis learning. In addition, we estimated the neurotransmission related to the salt chemotaxis learning using the neural network analysis. Moreover, we started the examination for mutants without oxidative stress response genes.
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Report
(6 results)
Research Products
(80 results)
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[Journal Article] Radiation Biology of Caenorhabditis elegans: Germ Cell Response, Aging and Behavior2010
Author(s)
Sakashita T, Takanami T, Yanase S, Hamada N, Suzuki M, Kimura T, Kobayashi Y, Ishii N, Higashitani A
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Journal Title
Journal of Radiation Research
Volume: 51
Issue: 2
Pages: 107-121
DOI
NAID
ISSN
0449-3060, 1349-9157
Related Report
Peer Reviewed
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[Journal Article] Effects of Ionizing Radiation on Locomotory Behavior and Mechanosensation in Caenorhabditis elegans2009
Author(s)
Suzuki M, Sakashita T, Yanase S, Kikuchi M, Ohba H, Higashitani A, Hamada N, Funayama T, Fukamoto K, Tsuji T, Kobayashi Y
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Journal Title
Journal of Radiation Research
Volume: 50
Issue: 2
Pages: 119-125
DOI
NAID
ISSN
0449-3060, 1349-9157
Related Report
Peer Reviewed
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[Journal Article] Effects of ionizing radiation on locomotory behavior and mechanosensation in Caenorhabditis elegans2009
Author(s)
Suzuki M., Sakashita T., Yanase S., Kikuchi M., Ohba H., Higashitani A., Hamada N., Funayama T., Fukamoto K., Tsuji T., Kobayashi Y.
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Journal Title
J.Radiat.Res. 50
Pages: 119-125
NAID
Related Report
Peer Reviewed
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[Presentation] COMPARATIVE STUDY OF SEVERAL BEHAVIORS IN CAENORHABDITIS ELEGANS FOLLOWING HIGH-LET RADIATION EXPOSURE2008
Author(s)
Sakashita T, Suzuki M, Hamada N, Fukamoto K, Yokota Y, Sora S, Kakizaki T, Wada S, Funayama T, Kobayashi Y
Organizer
COSPAR2008
Place of Presentation
モントリオール市,カナダ
Year and Date
2008-07-17
Related Report
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