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A model for estimation of genetic risk of radiation of human female exposure

Research Project

Project/Area Number 20310033
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research Institution放射線影響研究所 (2011)
Radiation Effects Research Foundation (2008-2010)

Principal Investigator

ASAKAWA Jun-ichi (ASAKAWA Jun-Ichi)  放射線影響研究所, 遺伝学部, 主任研究員 (10359458)

Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords未熟卵母細胞 / DNA2次元電気泳動 / 放射線被ばく / 遺伝リスク / 未成熟卵母細胞 / DNA 2次元電気泳動法 / マイクロアレイCGH法 / ヒト女性 / 被ばく / 遺伝的影響 / ラット / 女性被ばくモデル / DNA 2DE / マイクロアレイ / 放射線
Research Abstract

We estimated the mutation induction rate by examining DNA samples of 750 F1 rats derived from immature oocytes of dams irradiated with 2.5 Gy of gamma rays and 750 controls by the two-dimensional electrophoresis. There was no increase of deletion mutations in the exposed group. Our data, although still preliminary, imply that the genetic risk of radiation in female immature oocytes is smaller than that in male spermatogonia.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (7 results)

All 2010 2009

All Presentation (7 results)

  • [Presentation] DNA2次元電気泳動法を用いた放射線のラット未熟卵母細胞に及ぼす遺伝的影響評価:ヒト女性被曝の動物モデル実験2010

    • Author(s)
      浅川順一
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] DNA2次元電気泳動法を用いた放射線のラット未熟卵母細胞に及ぼす遺伝的影響評価:ヒト女性被曝の動物モデル実験2010

    • Author(s)
      浅川順一、上口勇次郎、金岡里充、中本芳子、辻隆弘、三嶋秀治、三浦昭子、金子順子、羽場博、今中正明、片山博昭、Harry M.Cullings、神谷研二、中村典
    • Organizer
      第53回日本放射線影響学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-20
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] DNA2次元電気泳動法を用いた放射線のラット未熟卵母細胞に及ぼす遺伝的影響評価2010

    • Author(s)
      浅川順一
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] A genetic risk estimate of radiation in mice and rats based on whole genome scanning by two-dimensional DNA gel2009

    • Author(s)
      浅川順一
    • Organizer
      欧州放射線影響学会
    • Place of Presentation
      プラハ
    • Year and Date
      2009-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] メスラットを用いた放射線の遺伝的影響評価2009

    • Author(s)
      浅川順一
    • Organizer
      中国支部・日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-07-29
    • Related Report
      2011 Final Research Report
  • [Presentation] メスラットを用いた放射線の遺伝的影響評価2009

    • Author(s)
      浅川順一、上口勇次郎、片山博昭、Harry M.Cullings、中村典
    • Organizer
      第34回中国地区放射線影響研究会
    • Place of Presentation
      広島
    • Year and Date
      2009-07-29
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] メスラットを用いた放射線の遺伝的影響評価2009

    • Author(s)
      浅川順一
    • Organizer
      中国地区放射線影響研究会
    • Place of Presentation
      広島
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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