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Developmental neurotoxicity of environmental chemicals : Development of an evaluation method through toxicogenomic approach

Research Project

Project/Area Number 20310037
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionAoyama Gakuin University

Principal Investigator

TASHIRO Tomoko  Aoyama Gakuin University, 理工学部, 教授 (50114541)

Co-Investigator(Kenkyū-buntansha) NEGISHI Takayuki  青山学院大学, 理工学部, 助教 (80453489)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords環境 / 神経科学 / 発生・分化 / マイクロアレイ / 発達神経毒性 / 環境化学物質 / トキシコゲノミクス
Research Abstract

In order to develop an efficient method to evaluate developmental neurotoxicity of chemicals, we analyzed gene expression changes in the brain of rats fetally exposed to tributyl tin (TBT) or thalidomide using original oligonucleotide microarrays. About 450 developmentally regulated genes were selected experimentally, and gene-specific 45-mer oligonucletide probes were spotted onto microarrays. The results showed that sensitivity of brain regions and gene groups were significantly different between the 2 chemicals, indicating that neurotoxicity arising from 2 different mechanisms could be effectively detected and distinguished by this method.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (47 results)

All 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (37 results)

  • [Journal Article] Analysis of gene expression changes associated with long-lasting synaptic enhancement in hippocampal slice cultures after repetitive exposures to glutamate.2010

    • Author(s)
      Kawaai K, Tominaga-Yoshino K, Urakubo T, Taniguchi N, Kondoh Y, Tashiro H, Ogura A, Tashiro T.
    • Journal Title

      J Neurosci.Res. 88(13)

      Pages: 2911-2922

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced inhibitory effects of TBT chloride on the development of F1 rats.2010

    • Author(s)
      Asakawa H, Tsunoda M, Kaido T, Hosokawa M, Sugaya C, Inoue Y, Kudo Y, Satoh T, Katagiri H, Akita H, Saji M, Wakasa M, Negishi T, Tashiro T, Aizawa Y.
    • Journal Title

      Arch.Environ.Contam.Toxicol. 58(4)

      Pages: 1065-1073

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of gene expression changes associated with long-lasting synaptic enhancement in hippocampal slice cultures after repetitive exposures to glutamate.2010

    • Author(s)
      Kawaai K, Tominaga-Yoshino K, Urakubo T, Taniguchi N, Kondoh Y, Tashiro H, Ogura A, Tashiro T.
    • Journal Title

      J Neurosci Res.

      Volume: Oct ; 88(13) Pages: 2911-2922

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of gene expression changes associated with long-lasting synaptic enhancement in hippocampal slice cultures after repetitive exposures to glutamate2010

    • Author(s)
      河合克宏
    • Journal Title

      J.Neurosci.Res. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MAP2-mediated in vitro interactions of brain microtubules and their modulation by cAMP.2009

    • Author(s)
      Leterrier JF, Kurachi M, Tashiro T, Janmey PA
    • Journal Title

      Eur.Biophys.J. 38(4)

      Pages: 381-393

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in gene expression of glutamate receptors and exocytosis-related factors by a hydroxylated-polychlorinated biphenyl in the developing rat brain.2009

    • Author(s)
      Takahashi M, Negishi T, Imamura M, Sawano E, Kuroda Y, Yoshikawa Y, Tashiro T.
    • Journal Title

      Toxicology 257(1-2)

      Pages: 17-24

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 80K-H interacts with inositol 1,4,5-trisphosphate (IP3) receptors and regulates IP3-induced calcium release activity.2009

    • Author(s)
      Kawaai K, Hisatsune C, Kuroda Y, Mizutani A, Tashiro T, Mikoshiba K.
    • Journal Title

      J.Biol.Chem. 284(1)

      Pages: 372-380

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in gene expression of glutamate receptors and exocytosis-related factors by a hydroxylated-polychlorinated biphenyl in the developing rat brain.2009

    • Author(s)
      高橋理貴
    • Journal Title

      Toxicology 257

      Pages: 17-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 80K-H interacts with inositol 1, 4, 5-trisphosphate receptors and regulates IP_3-induced calcium release activity.2009

    • Author(s)
      河合克宏
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 372-380

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MAP2-mediated in vitro interactions of brain microtubules and their modulation by cAMP.2009

    • Author(s)
      Leterrier, J. F.
    • Journal Title

      European Journal of Biophysics 38

      Pages: 381-393

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of thyroid hormone on the survival and neurite outgrowth of cultured cerebellar granule cells2010

    • Author(s)
      小柳洸志, 根岸隆之, 田代朋子
    • Organizer
      10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
    • Place of Presentation
      Phuket
    • Year and Date
      2010-10-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of thyroid hormone on the survival and neurite outgrowth of cultured cerebellar granule cells2010

    • Author(s)
      Oyanagi, K., Negishi, T., Tashiro, T.
    • Organizer
      10th Biennial Meeting of the Asia-Pacific Society for neurochemistry
    • Place of Presentation
      タイ・プーケット
    • Year and Date
      2010-10-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of gene expression profiles in the hippocampus and cerebellum of the Goto-Kakizaki rat, and animal model of type 2 diabetes2010

    • Author(s)
      Uno T., Ishibashi Y, Takahashi M., Negishi T., Tashiro T.
    • Organizer
      10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
    • Place of Presentation
      Phuket
    • Year and Date
      2010-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Investigation of cerebral development in cynomolgus monkey-histological and biochemical analyses2010

    • Author(s)
      Negishi T., Oyanagi K., Takahashi M., Imai N., Ihara T., Tashiro T.
    • Organizer
      10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
    • Place of Presentation
      Phuket
    • Year and Date
      2010-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Local thyroid hormone metabolism in the hippocampus of senescence-accelerated SAMP8 mice2010

    • Author(s)
      澤野恵梨香, 根岸隆之, 田代朋子
    • Organizer
      10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
    • Place of Presentation
      Phuket
    • Year and Date
      2010-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of gene expression profiles in the hippocampus and cerebellum of the Goto-Kakizaki rat, and animal model of type 2 diabetes2010

    • Author(s)
      Uno T., Ishibashi Y., Takahashi M., Negishi T., Tashiro T.
    • Organizer
      10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
    • Place of Presentation
      タイ・プーケット
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Investigation of cerebral development in cynomolgus monkey-histological and biochemical analyses2010

    • Author(s)
      Negishi T., Oyanagi K., Takahashi M., Imai N., Ihara T., Tashiro T.
    • Organizer
      10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
    • Place of Presentation
      タイ・プーケット
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Local thyroid hormone metabolism in the hippocampus of senescence-accelerated SAMP8 mice2010

    • Author(s)
      Sawano E., Negishi T., Tashiro T.
    • Organizer
      10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
    • Place of Presentation
      タイ・プーケット
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小脳アストロサイトにおけるジフェニルアルシン酸による酸化ストレスと神経ペプチドおよび血管作動性ペプチドの産生2010

    • Author(s)
      根岸隆之、高橋理貴、小柳洸志、大西大空、平野靖史郎、田代朋子
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 周産期トリブチルスズ曝露による、成熟後のF1ラットの神経毒性:遺伝子発現と行動学試験を指標として2010

    • Author(s)
      角田正史、竹内裕紀、吉岡良祐、根岸隆之、池内龍太郎、峡戸孝也、細川まゆ子、菅谷ちえ美、田代朋子、相澤好治
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 小脳アストロサイトにおけるジフェニルアルシン酸による酸化ストレスと神経ペプチドおよび血管作動性ペプチドの産生2010

    • Author(s)
      根岸隆之、高橋理貴、小柳洸志、大西大空、平野靖史郎、田代朋子
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 周産期トリブチルスズ曝露による、成熟後のF1ラットの神経毒性:遺伝子発現と行動学試験を指標として2010

    • Author(s)
      角田正史、竹内裕紀、吉岡良祐、根岸隆之、池内龍太郎、峡戸孝也、細川まゆ子、菅谷ちえ美、田代朋子、相澤好治
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 学習記憶障害を特徴とする老化促進モデルマウスSAMP8海馬における甲状腺ホルモン代謝の変化2010

    • Author(s)
      澤野恵梨香、根岸隆之、田代朋子
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 培養小脳顆粒細胞における甲状腺ホルモンT4の細胞死および神経突起伸展に及ぼす影響2010

    • Author(s)
      小柳洸志、根岸隆之、田代朋子
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 学習記憶障害を特徴とする老化促進モデルマウスSAMP8海馬における甲状腺ホルモン代謝の変化2010

    • Author(s)
      澤野恵梨香、根岸隆之、田代朋子
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 培養小脳顆粒細胞における甲状腺ホルモンT4の細胞死および神経突起伸展に及ぼす影響2010

    • Author(s)
      小柳洸志、根岸隆之、田代朋子
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 学習記憶障害を特徴とするSAMP8海馬における甲状腺ホルモン関連遺伝子の発現変化2010

    • Author(s)
      澤野恵梨香、中森裕介、根岸隆之、田代朋子
    • Organizer
      第25回老化促進モデルマウス(SAM)研究協議会
    • Place of Presentation
      金沢大学サテライト・プラザ
    • Year and Date
      2010-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 学習記憶障害を特徴とするSAMP8海馬における甲状腺ホルモン関連遺伝子の発現変化2010

    • Author(s)
      澤野恵梨香、中森裕介、根岸隆之、田代朋子
    • Organizer
      第25回 老化促進モデルマウス(SAM)研究協議会
    • Place of Presentation
      金沢大学サテライト・プラザ(金沢)
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of thyroid hormone in CNS development and function2009

    • Author(s)
      田代朋子
    • Organizer
      ISN 9^<th> Advanced School for Neurochemistry
    • Place of Presentation
      GyoengJu, South Korea
    • Year and Date
      2009-08-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット脳の発達に対するトリブチルスズ曝露の影響に関する二世代トキシコジェノミック研究2009

    • Author(s)
      角田正史、若佐美佳、浅川秀雄、高橋理貴、根岸隆之、峡戸孝也、細川まゆ子、菅谷ちえ美、井上葉子、相澤好治、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      伊香保ホテル天坊
    • Year and Date
      2009-06-24
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット脳の発達に対するトリブチルスズ曝露の影響に関する二世代トキシコジェノミック研究2009

    • Author(s)
      角田正史
    • Organizer
      第52回 日本神経化学会
    • Place of Presentation
      伊香保・ホテル天坊
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 2型糖尿病モデル・GKラットの脳におけるホモシステイン代謝の変化2009

    • Author(s)
      宇野健史、石橋瑛、高橋理貴、根岸隆之、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      伊香保ホテル天坊
    • Year and Date
      2009-06-23
    • Related Report
      2010 Final Research Report
  • [Presentation] GABA神経伝達機構の発達における甲状腺ホルモンの役割2009

    • Author(s)
      澤野恵梨香、高橋理貴、船津尚子、木村洋人、根岸隆之、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      伊香保ホテル天坊
    • Year and Date
      2009-06-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 小脳顆粒細胞におけるジフェニルアルシン酸による酸化ストレスと細胞死2009

    • Author(s)
      根岸隆之、高橋理貴、小柳洸志、大西大空、平野靖史郎、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      伊香保ホテル天坊
    • Year and Date
      2009-06-22
    • Related Report
      2010 Final Research Report
  • [Presentation] SAMP8海馬と脈絡叢におけるTtrとAppの発現2009

    • Author(s)
      降旗千恵、渡辺貴志、猪狩寛子、嘉山巧、鴻野貴司、鈴木孝昌、太田浩良、野村靖幸、田代.子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      伊香保ホテル天坊
    • Year and Date
      2009-06-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 繰り返しグルタミン酸刺激誘発性の長期神経可塑性に伴う遺伝子発現変化の解析2009

    • Author(s)
      河合克宏、冨永-吉野恵子、谷口直子、御子柴克彦、小倉明彦、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      伊香保ホテル天坊
    • Year and Date
      2009-06-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 培養小脳顆粒細胞における低カリウム誘発細胞死に対する甲状腺ホルモンT4の細胞保護作用2009

    • Author(s)
      小柳洸志、高橋理貴、根岸隆之、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      伊香保ホテル天坊
    • Year and Date
      2009-06-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 培養小脳顆粒細胞における低カリウム誘発細胞死に対する甲状腺ホルモンT4の細胞保護作用2009

    • Author(s)
      小柳洸志
    • Organizer
      第52回 日本神経化学会
    • Place of Presentation
      伊香保・ホテル天坊
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小脳穎粒細胞におけるジフェニルアルシン酸による酸化ストレスと細胞死2009

    • Author(s)
      根岸隆之
    • Organizer
      第52回 日本神経化学会
    • Place of Presentation
      伊香保・ホテル天坊
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] SAMP8海馬と脈絡叢におけるTtrとAppの発現2009

    • Author(s)
      降旗千恵
    • Organizer
      第52回 日本神経化学会
    • Place of Presentation
      伊香保・ホテル天坊
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 繰り返しグルタミン酸刺激誘発性の長期神経可塑性に伴う遺伝子発現変化の解析2009

    • Author(s)
      河合克宏
    • Organizer
      第52回 日本神経化学会
    • Place of Presentation
      伊香保・ホテル天坊
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規相互作用蛋白質80K-Hによるイノシトール3リン酸受容体のカルシウム放出活性制御2008

    • Author(s)
      河合克宏、久恒智博、田代朋子、御子柴克彦
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] トリブチルスズ経世代曝露による発達期脳の遺伝子発現変化2008

    • Author(s)
      若佐美佳、今村誠、吉岡良祐、高橋理貴、根岸隆之、角田正史、相澤好治、田代英夫、田代朋子
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 初代培養ラット小脳顆粒細胞における低カリウム誘発細胞死に対する内因性グルタミン酸の役割2008

    • Author(s)
      小柳洸志、高橋理貴、根岸隆之、田代朋子
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 胎生期サリドマイド曝露ラット大脳皮質におけるセロトニン・システムの生後発達異常2008

    • Author(s)
      田代朋子、山村尚志、鏡田大輔、宮城祐介、成田正明
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 胎生期サリドマイド曝露ラツト大脳皮質におけるセロトニン・システムの生後発達異常2008

    • Author(s)
      田代朋子
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] LPS誘導末梢性炎症による脳内甲状腺ホルモンシステムの変化2008

    • Author(s)
      高橋理貴、根岸隆之、澤野恵梨香、田代朋子
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-12
    • Related Report
      2010 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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