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Nano-magnetic sensing system for biomedical devices

Research Project

Project/Area Number 20310077
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Microdevices/Nanodevices
Research InstitutionTokyo Institute of Technology

Principal Investigator

KITAMOTO Yoshitaka  Tokyo Institute of Technology, 大学院・総合理工学研究科, 准教授 (10272676)

Co-Investigator(Renkei-kenkyūsha) TSUGE Takeharu  東京工業大学, 大学院・総合理工学研究科, 准教授 (70332260)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywordsナノバイオ / スピントロニクス / 磁性ナノ粒子 / スピンエレクトロニクス / マイクロ・ナノデバイス
Research Abstract

We studied developments of magnetic beads and magnetic sensors and their integration in a microfluidic device for detecting protein, DNA, virus, and etc in bio-medical applications. Magnetic beads, which is an assembly composed of Fe-Pt nanoparticles, were obtained using polymer dispersing agents, and they exhibited a high magnetic response. A fabrication process for magnetic-field sensors based on the tunneling-magnetoresistance effect and the integration into a microfluidic device were developed.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009 2008

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (14 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] Ferromagnetic FePt-Nanoparticles/ Polycation Hybrid Capsules Designed for a Magnetically Guided Drug Delivery System2011

    • Author(s)
      渕上輝顕, 河村亮, 北本仁孝, 中川勝, 並木禎尚
    • Journal Title

      Langmuir vol.27[6]

      Pages: 2923-2928

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ferromagnetic FePt-Nanoparticles/Polycation Hybrid Capsules Designed for a Magnetically Guided Drug Delivery System2011

    • Author(s)
      Teruaki Fuchigami, Ryo Kawamura, Yoshitaka Kitamoto, et. al.i
    • Journal Title

      Langmuir

      Volume: 27 Pages: 2923-2928

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FePt/SiO2複合型磁性ナノ粒子の作製2010

    • Author(s)
      渕上輝顕, 河村亮, 山崎陽太郎, 北本仁孝, 中川勝, 並木禎尚
    • Journal Title

      J.Jpn.Soc.Powder Powder Metallurgy vol.57[9]

      Pages: 636-641

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] FePt/SiO_2複合型磁性ナノ粒子の作製2010

    • Author(s)
      渕上輝顕, 河村亮, 山崎陽太郎, 北本仁孝. 中川勝, 並太禎尚
    • Journal Title

      J.Jpn.Soc.Powder Powder Metallurgy

      Volume: 57 Pages: 636-641

    • NAID

      10026725766

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Synthesis of FePt Nanoparticles with High Alternate Current Magnetic Susceptibility for Biomedical Applications2009

    • Author(s)
      Yoshitaka Kitamoto, Jing-Sha He
    • Journal Title

      Electrochimica Acta vol.54[25]

      Pages: 5969-5972

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anomalous magnetic behavior in FePt nanoparticles chemically synthesized with polymer protective agent2009

    • Author(s)
      Takashi Iwamoto, Yoshitaka Kitamoto, Naoki Toshima
    • Journal Title

      Physica B vol.404

      Pages: 2080-2085

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Annealing-induced Solid-phase Epitaxy at Interfaces between CoFeB Layers and MgO Barrier-layer in CoFeB/MgO/CoFeB Magnetic Tunnel Junctions and their Magnetic Properties2009

    • Author(s)
      Y.Kitamoto, T.Takeuchi, K.Tsunekawa, Y.S.Choi, Y.Nagamine, D.D.Djayaprawira
    • Journal Title

      ECS Transactions vol.16[45]

      Pages: 37-44

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 水溶性高分子で保護したFe-Ptナノ粒子の合成2009

    • Author(s)
      北本仁孝, 何浄沙, 山崎陽太郎
    • Journal Title

      J.Jpn.Soc.Powder Powder Metallurgy vol.56[9]

      Pages: 568-573

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] FePt/酸化鉄コアシェル・ナノ粒子の作製2009

    • Author(s)
      北本仁孝, 木村健一郎, 山崎陽太郎
    • Journal Title

      J.Jpn.Soc.Powder Powder Metallurgy vol.56[3]

      Pages: 121-126

    • NAID

      10025398302

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 水溶性高分子で保護したFe-Ptナノ粒子の合成2009

    • Author(s)
      大本仁孝, 何浄沙, 山崎陽太郎
    • Journal Title

      J.Jpn.Soc.Powder Powder Metallurgy 56

      Pages: 568-573

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anomalous magnetic behavior in FePt nanoparticles chemically synthesized with polymer protective agent2009

    • Author(s)
      Takashi Iwamoto, Yoshitaka Kitamoto, Naoki Toshima
    • Journal Title

      Physica B 404

      Pages: 2080-2085

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Syntesis of FePt Nanoparticles with High Alternate Current Magnetic Susceptibility for Biomedical Applications2009

    • Author(s)
      Yoshitaka Kitamoto, Jing-Sha He
    • Journal Title

      Electrochimica Acta 54

      Pages: 5969-5972

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FePt/酸化鉄コアシェル・ナノ粒子の作製2009

    • Author(s)
      北本仁孝, 木村健一郎, 山崎陽太郎
    • Journal Title

      J. Jpn. Soc. Powder Powder Metallurgy 56

      Pages: 121-126

    • NAID

      10025398302

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] FePt-nanoparticles /polycation magnetic capsules designed for magnetically guided drug delivery system2010

    • Author(s)
      渕上輝顕, 河村亮, 北本仁孝, 中川勝, 並木禎尚
    • Organizer
      The 55th Annual Conference on Magnetism & Magnetic Materials
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 磁気誘導ドラッグ・デリバリー・システムに用いる柔軟なFePt/高分子電解質複合シェルから構成された磁性中空構造体2010

    • Author(s)
      渕上輝顕, 河村亮, 北本仁孝, 中川勝, 並木禎尚
    • Organizer
      第34回日本磁気学会学術講演会
    • Place of Presentation
      茨城県・つくば市
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 極薄で柔軟なFePt/高分子複合シェルを持つ磁性中空構造体2010

    • Author(s)
      渕上輝顕, 河村亮, 北本仁孝, 中川勝, 並木禎尚
    • Organizer
      2010年電気化学会・秋季大会
    • Place of Presentation
      厚木
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] ドラッグデリバリーシステムを模したマイクロ流路中の磁性微粒子捕捉実験2010

    • Author(s)
      大澤邦彦, 平田博之, 山崎陽太郎, 北本仁孝
    • Organizer
      粉体粉末冶金教会平成22年度春季大会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 磁気誘導ドラッグ・デリバリー・システムに用いる柔軟なFePt/高分子電解質複合シェルから構成された磁性中空構造体2010

    • Author(s)
      渕上輝顕, 河村亮, 北本仁孝, 中川勝, 並木禎尚
    • Organizer
      第34回日本磁気学会学術講演会
    • Place of Presentation
      つくば
    • Related Report
      2010 Final Research Report
  • [Presentation] バイオ・医療用磁性粒子分散体の交流磁化率2009

    • Author(s)
      平田博之, 北本仁孝
    • Organizer
      2009年電気化学会・秋季大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] バイオ・医療用磁性粒子分散体の交流磁化率2009

    • Author(s)
      平田博之, 北本仁孝
    • Organizer
      2009年電気化学会・秋季大会
    • Place of Presentation
      東京農工大学・小金井市
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 医療への応用に向けた磁性粒子分散溶液の磁気特性2009

    • Author(s)
      平田博之, 何浄沙, 山崎陽太郎, 北本仁孝
    • Organizer
      粉体粉末冶金協会講演概要集平成21年度春季大会
    • Place of Presentation
      京都
    • Year and Date
      2009-06-04
    • Related Report
      2010 Final Research Report
  • [Presentation] ンネル磁気抵抗効果型磁気センサー作製のためのドライエッチングプロセス2009

    • Author(s)
      王大千, 山田啓太, 北本仁孝
    • Organizer
      電気化学会第76回大会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-31
    • Related Report
      2010 Final Research Report
  • [Presentation] トンネル磁気抵抗効果型磁気センサー作製のためのドライエッチングプロセス2009

    • Author(s)
      王大千, 山田啓太, 北本仁孝
    • Organizer
      電気化学会第7 6回大会
    • Place of Presentation
      京都大学, 京都市
    • Year and Date
      2009-03-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chemical Synthesis of FePt/Fe-oxide Composite Nanoparticles with High Alternate Current Magnetic Susceptibility for Biomedical Applications2008

    • Author(s)
      Yoshitaka Kitamoto, Jing-Sha He
    • Organizer
      The 53rd Annual Conference on Magnetism & Magnetic Materials
    • Place of Presentation
      Austin, USA
    • Year and Date
      2008-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Chemical Synthesis of FePt/Fe-oxide Composite Nanoparticles with High Alternate Current Magnetic Susceptibility for Biomedical Applications2008

    • Author(s)
      Yoshitaka Kitamoto, Jing-Sha He
    • Organizer
      53^<rd> Annual Conference on Magnetism and Magnetic Materials
    • Place of Presentation
      Austin, Texas, USA
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 水溶性高分子で保護したFe-Ptナノ粒子の合成2008

    • Author(s)
      北本仁孝, 何浄沙, 山崎陽太郎
    • Organizer
      (社)粉体粉末冶金協会平成20年度秋季大会
    • Place of Presentation
      九州大学, 福岡市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chemical Synthesis of FePt Nanoparticles with High Alternate Current Magnetic Susceptibility for Biomedical Applications2008

    • Author(s)
      Yoshitaka Kitamoto, Jing-Sha He
    • Organizer
      The Seventh International Symposium on Electrochemical Micro & Nanosystem Technologies
    • Place of Presentation
      Kibbutz Ein Gedi, Israel
    • Year and Date
      2008-09-17
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 磁性粒子、及びその製造方法、並びに磁性粒子含有製剤2011

    • Inventor(s)
      並木禎尚、北本仁孝、渕上輝顕、河村亮、中川勝
    • Industrial Property Rights Holder
      学校法人慈恵大学、国立大学法人東京工業大学、国立大学法人東北大学
    • Filing Date
      2011-02-04
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 磁性粒子、及びその製造方法、並びに磁性粒子含有製剤2010

    • Inventor(s)
      並木禎尚, 北本仁孝, 渕上輝顕, 河村亮, 中川勝
    • Industrial Property Rights Holder
      学校法人慈恵大学, 国立大学法人東京工業大学, 国立大学法人東北大学
    • Industrial Property Number
      2010-025660
    • Filing Date
      2010-02-08
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 磁性微粒子含有剤形、及びその製造方法、並びに磁性微粒子含有製剤2009

    • Inventor(s)
      並木禎尚, 北本仁孝
    • Industrial Property Rights Holder
      学校法人慈恵大学, 国立大学法人東京工業大学
    • Industrial Property Number
      2009-269635
    • Filing Date
      2009-11-27
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 磁性微粒子含有剤形、びその製造方法、並びに磁性微粒子含有製剤2009

    • Inventor(s)
      並木禎尚, 北本仁孝
    • Industrial Property Rights Holder
      学校法人慈恵大学,国立大学法人東京工業大学
    • Industrial Property Number
      2009-269635
    • Filing Date
      2009-11-27
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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