| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Research Abstract |
It is well documented that eukaryotic genome is pervasively transcribed to generate numerous novel non-coding RNAs, but the significance of such transcription remains controversial. We found that yeast cell transcribes a bacterial genome maintained as an artificial chromosome, which should have no biological function, as efficiently as its natural chromosomes. We also showed that limiting transcriptional capacity of yeast leads to a preferential decrease in the level of novel non-coding RNA species identified in recent studies. These results do not contradict with the idea that pervasive transcription is largely functionless.
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