| Project/Area Number |
20310115
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
基礎ゲノム科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAI Kenta The University of Tokyo, 医科学研究所, 教授 (60217643)
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| Co-Investigator(Kenkyū-buntansha) |
KUSAKABE Takehiro 甲南大学, 理工学部, 教授 (40280862)
INOUE Kunio 神戸大学, 大学院・理学研究科, 教授 (40252415)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Yutaka 東京大学, 大学院・新領域創成科学研究科, 准教授 (40323646)
岡村 浩司 お茶の水女子大学, 生命報学教育研究センター, 特任講師 (80456194)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | ゲノム解析 / 組織特異的発現 / カタユウレイボヤ / メダカ / miRNA / Piwi / 進化的保存 / miRNA予測 / 小分子RNA / 特異的発現 / 次世代シークエンサー / ホヤ / microRNA / 比較ゲノム学 |
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| Research Abstract |
In recent years, it has been clarified that small RNAs, like miRNAs, play important roles in a wide range of cellular activities. In this study, taking the advantage of our collaborative experience in the analysis of transcriptional regulation in Ciona intestinalis, a model organism of vertebrates, we predicted a comprehensive set of miRNAs encoded in the Ciona genome. Then, a list of novel candidate genes were obtained with a reliability measure. For some genes showing interesting expression pattern, their evolutionary divergence/conservation was clarified through more detailed characterization.
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