Comprehensive finding of small RNAs encoded in a Ciona genome
| Project/Area Number |
20310115
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
基礎ゲノム科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAI Kenta The University of Tokyo, 医科学研究所, 教授 (60217643)
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| Co-Investigator(Kenkyū-buntansha) |
KUSAKABE Takehiro 甲南大学, 理工学部, 教授 (40280862)
INOUE Kunio 神戸大学, 大学院・理学研究科, 教授 (40252415)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Yutaka 東京大学, 大学院・新領域創成科学研究科, 准教授 (40323646)
岡村 浩司 お茶の水女子大学, 生命報学教育研究センター, 特任講師 (80456194)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | ゲノム解析 / 組織特異的発現 / カタユウレイボヤ / メダカ / miRNA / Piwi / 進化的保存 / miRNA予測 / 小分子RNA / 特異的発現 / 次世代シークエンサー / ホヤ / microRNA / 比較ゲノム学 |
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| Research Abstract |
In recent years, it has been clarified that small RNAs, like miRNAs, play important roles in a wide range of cellular activities. In this study, taking the advantage of our collaborative experience in the analysis of transcriptional regulation in Ciona intestinalis, a model organism of vertebrates, we predicted a comprehensive set of miRNAs encoded in the Ciona genome. Then, a list of novel candidate genes were obtained with a reliability measure. For some genes showing interesting expression pattern, their evolutionary divergence/conservation was clarified through more detailed characterization.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] The ANISEED database : Digitalrepresentation, formalization, and elucidation of a chordate developmentalprogram2010
Author(s)
Olivier Tassy, Delphine Dauga, FabriceDaian, Daniel Sobral, Francois Robin, Pierre Khoueiry, David Salgado, Vanessa Fox, Daniele Caillol, RenaudSchiappa, Baptiste Laporte, Anne Rios, Guillaume Luxardi, Takehiro Kusakabe, Jean-Stephane Joly, Sebastien Darras, Lionel Christiaen, Magali Contensin, Helene Auger, Clement Lamy, ClareHudson, Ute Rothbacher, Michael J.Gilchrist, Kazuhiro W.Makabe, KohjiHotta, Shigeki Fujiwara, Nori Satoh, Yutaka Satou, Patrick Lemaire
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Journal Title
Genome Res. 20(10)
Pages: 1459-1468
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[Presentation] カタユウレイボヤ脳胞におけるpiwiの新奇機能の解析(1H1700)2010
Author(s)
島井光太郎, 一瀬葵, 宮本由紀, 寺島泰子, 西辻光希, 白江-倉林麻貴, 中村輝, 日下部りえ, 中井謙太, 井上邦夫, 日下部岳広
Organizer
日本動物学会第81回東京大会
Place of Presentation
東京大学教養学部(駒場キャンパス)(口演発表)
Year and Date
2010-09-23
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[Presentation] Gene expression patterns andpossible developmental roles of proteinfamilies involved in biogenesis and functions of small noncoding RNAs inCiona intestinalis2010
Author(s)
T.Kusakabe, A.Ichinose, Y.Miyamoto, Y.Terashima, K.Shimai, K.Nishitsuji, M.Shiraekurabayashi, A.Nakamura, R.Kusakabe, K.Nakai, K.Inoue
Organizer
2nd Joint Meeting OfThe SFBD and JSDB 2010-From Cellsto Organs
Place of Presentation
InstitutPasteur-Paris (France)
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