| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
Goal of this study is to elucidate the structure and divergence of t-haplotype genome in which genetic recombination has been suppressed for over million years. Large scale DNA rearrangements including deletions and duplications were revealed by Array-CGH method, inferring the break points of inversions associated with t-haplotypes. BAC genomic library was constructed from tw5 haplotype, and clones corresponding to the t-complex region were isolated and sequenced. Exceptionally high incidence of SNPs (single nucleotide polymorphisms) has been detected between the tw5haplotype and the standard laboratory mouse strain.
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