Structural analysis of genomic regions where genetic recombination was suppressed for over million years
| Project/Area Number |
20310118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
基礎ゲノム科学
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ABE Kuniya The Institute of Physical and Chemical Research, 動物変異動態解析技術開発チーム, チームリーダー (40240915)
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| Co-Investigator(Kenkyū-buntansha) |
OOTA Satoshi 独立行政法人理化学研究所, 情報解析技術室, 専任研究員 (30391890)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | ゲノム進化 / 再編 / 染色体組換え / t-ハプロタイプ / BACライブラリー / ゲノム再編成 / ゲノム進化・再編 |
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| Research Abstract |
Goal of this study is to elucidate the structure and divergence of t-haplotype genome in which genetic recombination has been suppressed for over million years. Large scale DNA rearrangements including deletions and duplications were revealed by Array-CGH method, inferring the break points of inversions associated with t-haplotypes. BAC genomic library was constructed from tw5 haplotype, and clones corresponding to the t-complex region were isolated and sequenced. Exceptionally high incidence of SNPs (single nucleotide polymorphisms) has been detected between the tw5haplotype and the standard laboratory mouse strain.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Usp46, encoding a ubiquitin specific peptidase, is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests.2009
Author(s)
Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T,Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K, Yoshimura T, Nabeshima T, Ebihara S
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Journal Title
Nature Genetics 41
Pages: 688-695
Related Report
Peer Reviewed
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[Journal Article] The mouse resources at the RIKEN BioResource Center.2009
Author(s)
Yoshiki A., Ike F., Mekada K., Kitaura Y., Nakata H., Hiraiwa N., Mochida K., Ijuin M., Kadota M., Murakami A., Ogura A., Abe K., Moriwaki K., Obata Y.
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Journal Title
Exp.Anim. 58
Pages: 85-96
NAID
Related Report
Peer Reviewed
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[Journal Article] A high-speed congenic strategy using first-wave male germ cells.2009
Author(s)
Ogonuki N, Inoue K, Hirose M, Miura I, Mochida K, Sato T, Mise N, Mekada K, Yoshiki A, Abe K, Kurihara H, Wakana S, Ogura A
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Journal Title
PLoS One 4(3)(Epub 2009 Mar 31)
Related Report
Peer Reviewed
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