| Project/Area Number |
20310127
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Hokkaido University |
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Principal Investigator |
MONDE Kenji Hokkaido University, 大学院・先端生命科学研究院, 教授 (40210207)
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Nobuaki 北海道大学, 大学院・先端生命科学研究院, 特任准教授 (80372267)
TANIGUCHI Tohru 北海道大学, 大学院・先端生命科学研究院, 助教 (00587123)
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| Co-Investigator(Renkei-kenkyūsha) |
MIURA Nobuaki 北海道大学, 大学院・先端生命科学研究院, 特任准教授 (80372267)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 生体機能関連物質 / トランス脂肪酸 / キラル / VCD / 脂質 / ジアシルグリセロール / グリセロール / 糖脂質 / グリセロ糖脂質 / グリコシル化 |
|---|
| Research Abstract |
Glycerolipids are essential substances for sustaining our life. Although the number of their chiral carbon is only one like most of amino acids, their stereochemistry has not been assigned with ease. In order to establish a new analytical method for determination of their absolute configurations, optically pure glycerolipids and related compounds were prepared by chemical synthesis, and subjected to the "Vibrational Circular Dichromism" measurement. The precise analysis of their spectral data resulted in a discovery of an empirical rule on the stereochemistry of diacylglycerolipids including glycolipids for the first time.
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