Synthesis of molecular probes for exploring the novel receptor involved in the allodynia induction
| Project/Area Number |
20310131
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Gifu University |
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Principal Investigator |
FURUTA Kyoji Gifu University, 医学系研究科, 准教授 (40173538)
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| Co-Investigator(Renkei-kenkyūsha) |
MINAMI Toshiaki 大阪医科大学, 医学研究科, 教授 (00257841)
DOI Hisashi , 理化学研究所・分子イメージング科学研究センター, チームリーダー (00421818)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | アロディニア / 神経障害性痙痛 / 分子プローブ / 陽電子放射画像撮影法 / PET / アクロメリン酸 / カイニン酸受容体 / 受容体 / 陽電子放射断層画像撮影法 |
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| Research Abstract |
In order to explore a novel receptor involved in the induction of allodynia (a typical symptom of neuropathic pain), we synthesized molecular probes that enable us to visualize the site of action of drug molecules in vivo. Imaging analysis using one of the probes in rats revealed the specific accumulation of the molecule to the regions of cerebral cortex, hippocampus and spinal cord. This study also demonstrated the possible involvement of kainate-type receptor in allodynia, suggesting a drug that can modulate the function of the receptor becomes a potential candidate for the therapeutic agent for allodynia.
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Report
(4 results)
Research Products
(12 results)
