Studies on Molecular Science of Biologically Active Natural Products Based on Chemical Synthesis
| Project/Area Number |
20310137
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Osaka City University |
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Principal Investigator |
MORIMOTO Yoshiki 大阪市立大学, 大学院・理学研究科, 教授 (90244631)
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| Co-Investigator(Renkei-kenkyūsha) |
DOE Matsumi 大阪市立大学, 大学運営本部, 技術職員 (90433317)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | 生物活性分子の設計・合成 / 化学合成 / オキサスクアレノイド / バイオミメスティック合成 / 全立体構造決定 / ハウアミン / テウリレン / イソデヒドロチルシフェロール / ハウアミンB / 仮想生合成前駆体 / スクアレンテトラエポキシド / カスケード型環化反応 / バイオミメティック合成 / オマエザキアノール / 立体化学 / グラブレスコール / 全合成 / 生合成 |
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| Research Abstract |
To advance studies on molecular science of triterpene polyethers and alkaloids, biologically active natural products(secondary metabolites from organisms), their chemical syntheses were carried out. As a result, we have succeeded in determining the entire stereostructure of omaezakianol by the asymmetric total synthesis, developing the chemical synthesis method of isodehydrothyrsiferol, and chemically reproducing biomimetic oxacyclizations of teurilene and ekeberin D_4.In addition, an efficient synthesis of the indeno-tetrahydropyridine skeleton of houamine B has also been accomplished.
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Report
(6 results)
Research Products
(108 results)
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[Journal Article] Cytotoxic Eunicellin-Type Diterpenes from the Soft Coral Liophyton viscudium2011
Author(s)
Tetsuo Iwagawa, Taiki Kusatsu, Keiko Tsuha, Toshiyuki Hamada, Hiroaki Okamura, Tatsuhiko Furukawa, Shin-ichi Akiyama, Matsumi Doe, Yoshiki Morimoto, Fumihito Iwase, and Kaoru Takemura
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Journal Title
Heterocycles
Volume: 83
Issue: 9
Pages: 2149-2155
DOI
Related Report
Peer Reviewed
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[Journal Article] Cytotoxic Isomalabaricane Derivatives and a Monocyclic Triterpene Glycoside from the Sponge Rhabdastrella globostellata2010
Author(s)
Miyabi Hirashima, Kazuomi Tsuda, Toshiyuki Hamada, Hiroaki Okamura, Tatsuhiko Furukawa, Shin-ichi Akiyama, Yusuke Tajitsu, Ryuji Ikeda, Masaharu Komatsu, Matsumi Doe, Yoshiki Morimoto, Motoo Shiro, Rob W. M. van Soest, Kaoru Takemura, and Tetsuo Iwagawa
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Journal Title
J. Nat. Prod.
Volume: 73
Issue: 9
Pages: 1512-1518
DOI
Related Report
Peer Reviewed
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[Journal Article] Cytotoxic Isomalabricane Derivatives and a Monocyclic Triterpene Glycoside from the Sponge Rhabdastrella globostellata2010
Author(s)
Miyabi Hirashima, Kazuomi Tsuda, Toshiyuki Hamada, Hiroaki Okamura, Tatsuhiko Furukawa, Shin-ichi Akiyama, Yusuke Tajitsu, Ryuji Ikeda, Masaharu Komatsu, Matsumi Doe, Yoshiki Morimoto, Motoo Shiro, Rob W.M.van Soest, Kaoru Takemura, Tetsuo Iwagawa
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Journal Title
J.Nat.Prod. 73
Pages: 1512-1518
Related Report
Peer Reviewed
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[Presentation] 天然物の全合成2009
Author(s)
森本善樹
Organizer
新化学科の将来像を探るシンポジウム
Place of Presentation
大阪市立大学
Year and Date
2009-08-24
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