Development of designed agents that selectively photo-degrade certain proteins and oligosaccharides
| Project/Area Number |
20310140
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
TOSHIMA Kazunobu Keio University, 理工学部, 教授 (60217502)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 生物活性分子 / 分子設計 / 合成 / タンパク / 糖 / 光分解 / 細胞 / 分子標的薬 / アルツハイマー病 / アミロイドβ / フラーレン / タンパク光分解 / アントラキノン / サクラシメジレクチン / マンノシド / 糖鎖光分解 / 糖鎖 / ボロン酸 / 結核菌 / HIV-1プロテアーゼ / ハイブリッド / 分子デザイン / 化学合成 |
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| Research Abstract |
Several agents, that target-selectively photo-degrade certain disease-related proteins and oligosaccharides, were designed and synthesized. Furthermore, it was found the agents thus developed work not only in test tube but also in disease-related cells. From these studies, a new approach for the design of light-activated and molecular-targeted medicines has been established.
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Report
(4 results)
Research Products
(82 results)
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[Presentation]2009
Author(s)
D.Takahashi, S.Tanimoto, S.Sakai, K.Toshima
Organizer
The 25^<th> Naito Conference on Chemical Biology [II]
Place of Presentation
Sapporo
Year and Date
2009-09-09
Related Report
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