| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Research Abstract |
Apparatus that can measure dynamic behaviors of a single molecule in solution phase was constructed by combining an optical microscope, detectors of the fluorescence, and laser light sources. This apparatus was applied to the elucidation of conformational changes of DNA in water in sub nanosecond to millisecond range. The analysis of photon bunching and anti-bunching behaviors of the fluorescence from a moiety connected with DNA led to the conclusion that the faster conformational rearrangement occurring in several hundreds of ns was followed by the slower one with several-several tens μs time region.
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