Study on the fluctuation of biomolecules around the thermal equilibriumpoint by means of single molecule measurements.
| Project/Area Number |
20350009
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
MIYASAKA Hiroshi Osaka University, 大学院・基礎工学研究科, 教授 (40182000)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 単一分子計測 / 電子移動 / DNA / 構造揺らぎ / 光子統計 / 単一光子計測 / 生体揺らぎ / 電子移動反応 |
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| Research Abstract |
Apparatus that can measure dynamic behaviors of a single molecule in solution phase was constructed by combining an optical microscope, detectors of the fluorescence, and laser light sources. This apparatus was applied to the elucidation of conformational changes of DNA in water in sub nanosecond to millisecond range. The analysis of photon bunching and anti-bunching behaviors of the fluorescence from a moiety connected with DNA led to the conclusion that the faster conformational rearrangement occurring in several hundreds of ns was followed by the slower one with several-several tens μs time region.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Systematic Synthesis, Isolation, and Photophysical Properties of Linear-shaped Re(I) Oligomers and Polymers with 2 -20 units.2008
Author(s)
Y. Yamamoto, S. Sawa, Y. Funada, T, Morimoto, M. Falkenstrom, H. Miyasaka, S. Shishido, T. Ozeki, K. Koike, O. Ishitani
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Journal Title
Related Report
Peer Reviewed
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