|Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fluorine substituent has an α-cation-stabilizing effect as well as a leaving-group ability as a fluoride ion. Using these two properties in combination allows α-fluoro carbocations to be readily generated from fluoroalkenes and fluoroallenes. We have succeeded in highly efficient and selective domino and tandem cyclizations, which proceed via the α-fluoro carbocations to construct PAHs such as helicenes and acenes including higher-order helicenes. Moreover, fluorinated PAHs are produced by our methods. In the course of study, we have also established facile methods for the syntheses of 1, 1-difluoroalkenes and 1, 1-difluoroallenes as starting materials of our cyclizations.