Synthetic model study of reactive species involved in biological reactions for chemical elucidation of redox regulatory mechanism
| Project/Area Number |
20350017
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
GOTO Kei Tokyo Institute of Technology, 大学院・理工学研究科, 教授 (70262144)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 有機元素化学 / 有機元素科学 / 酵素モデル / 硫黄化合物 / レドックス制御 / ヨウ化スルフェニル / システイン誘導体 / 分子キャビティ / 立体保護 / ヒドックス制御 / N-ヒドロキシスルフェンアミド / デンドリマー / スルフィニルラジカル |
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| Research Abstract |
Cysteine residues located in clefts within the proteins are sterically restrained from forming inter- or intramolecular bridging bonds. The reactive intermediates generated by their reactions with reactive oxygen and nitrogen species play a crucial role in redox regulation. However, many of these intermediates are notoriously unstable in artificial systems, and model studies on these species have been difficult due to their instability. In this study, novel nano-sized molecular cavities with bowl-shaped frameworks were developed for modeling such sterically isolated environment and applied for the stabilization of highly reactive chemical species involved in redox regulations. Some of the mechanisms proposed for biological transformations were demonstrated experimentally by utilizing these model systems.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Catalyst-free Syntheses of [2]Rotaxanes Utilizing a Pentacoordinated Hydrosilane as an End-capping Agent2010
Author(s)
Domoto, Y., Fukushima, A., Kasuga, Y., Sase, S., Goto K., Kawashima, T.
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Journal Title
Org.Lett. 12
Pages: 2586-2589
Related Report
Peer Reviewed
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[Journal Article] Synthesis and Properties of Pentacoordinated Phenoxysilane and Carboxysilanes with Intramolecular Nitrogen-Silicon Coordination2010
Author(s)
Domoto, Y., Saruhashi, K., Fukushima, A., Sase, S., Goto K., Kawashima, T.
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Journal Title
Phosphorus, Sulfur Silicon Relat.Elem. 185
Pages: 1221-1229
Related Report
Peer Reviewed
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