| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Research Abstract |
Cysteine residues located in clefts within the proteins are sterically restrained from forming inter- or intramolecular bridging bonds. The reactive intermediates generated by their reactions with reactive oxygen and nitrogen species play a crucial role in redox regulation. However, many of these intermediates are notoriously unstable in artificial systems, and model studies on these species have been difficult due to their instability. In this study, novel nano-sized molecular cavities with bowl-shaped frameworks were developed for modeling such sterically isolated environment and applied for the stabilization of highly reactive chemical species involved in redox regulations. Some of the mechanisms proposed for biological transformations were demonstrated experimentally by utilizing these model systems.
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