Asymmetric Catalytic Synthesis of Optically Active Organoboron Compounds with Chiral Borylcopper Species
| Project/Area Number |
20350043
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
ITO Hajime Hokkaido University, 大学院・工学研究院, 教授 (90282300)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 不斉合成 / 合成化学 / 有機化学 / 触媒・化学プロセス / 銅 |
|---|
| Research Abstract |
Novel methods for efficient synthesis of optically active organoboron compounds with chiral copper(I)-catalyst have been developed. The reactions, which include copper(I) salts and chiral phosphine ligands, promote various borylation reaction to produce optically active organoboron compounds with high enantioselectivity. This method enables the asymmetric catalytic synthesis of unprecedented chiral cyclopropyl-, ally- and homoallyboronates, which will facilitate the synthesis of intermediates for medicines.
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] Copper(I)-Catalyzed Regioselective Monoborylation of 1,3-Enynes with an Internal Triple Bond : Selective Synthesis of 1,3-Dienylboronates and 3-Alkynylboronates2011
Author(s)
Sasaki, Y., Horita, Y., Zhong, C., Sawamura, M., Ito, H.
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Journal Title
Angew.Chem., Int.Ed.
Volume: 50
Pages: 2778-2782
Related Report
Peer Reviewed
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[Journal Article] Reversible Mechanochromic Luminescence of [(C_6F_5Au)_2(η-1, 4-diisocyanobenzene)]2008
Author(s)
Ito, H. ; Saito, T. ; Oshima, N. ; Kitamura, N. ; Ishizaka, S. ; Hinatsu, Y. ; Wakeshima, M. ; Kato, M. ; Tsuge, K. ; Sawamura, M.
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Journal Title
J. Am. Chem. Soc. 130
Pages: 10044-10045
Related Report
Peer Reviewed
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