BIOLOGICALLY IDENTIFIED PEPTIDE AS ADHESIVES FOR ENGINEERING PLASTICS

• Project/Area Number: 20350052
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Polymer chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: SERIZAWA Takeshi The University of Tokyo, 先端科学技術研究センター, 准教授 (30284904)
• Co-Investigator(Kenkyū-buntansha): MATSUNO Hisao 九州大学, 工学研究院, 助教 (50376696)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Keiji 九州大学, 工学研究院, 教授 (20325509)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000); Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
• Keywords: スクリーニング / エンプラ / ペプチド / ファージ / ポリエーテルイミド / 表面プラズモン共鳴 / 接着 / モチーフ / ペプチドジ

Research Abstract

Peptides that specifically bind to the surface of engineering plastic (EP) were identified via a phage display method. The binding of the identified peptides to EP was quantitatively analyzed. It was then evaluated whether the peptide derivatives designed as adhesives were applicable to adhere two EP films.

Research Products

• [Journal Article] Conjugated Polymer Nanoparticles Hybridized with the Peptide Aptamer (2011)
  • Author(s): Hirotaka Ejima, Kisei Matsumiya, Toshiki Sawada, Takeshi Serizawa
  • Journal Title: Chem.Commun. 印刷中
  • Peer Reviewed
• [Journal Article] Binding Analysis of Peptides that Recognize Preferentially Cis-Azobenzene Groups of Synthetic Polymers (2011)
  • Author(s): Jing Chen, Takeshi Serizawa, Makoto Komiyama
  • Journal Title: J.Pept.Sci. 17 Pages: 163-168
  • Peer Reviewed
• [Journal Article] Polymer-binding Peptides for the Noncovalent Modification of Polymer Surfaces : Effects of Peptide Density on the Subsequent Immobilization of Functional Proteins (2011)
  • Author(s): Takaaki Date, Jun Sekine, Hisao Matsuno, Takeshi Serizawa
  • Journal Title: ACS Appl.Mater.Interfaces 3 Pages: 351-359
  • Peer Reviewed
• [Journal Article] Noncovalent Functionalization of Disentangled Boron Nitride Nanotubes with Flavin Mononucleotides for Strong and Stable Visible-Light Emission in Aqueous Solution (2011)
  • Author(s): Zhenghong Gao, Chunyi Zhi, Yoshio Bando, Dmitri Golberg, Takeshi Serizawa
  • Journal Title: ACS Appl.Mater.Interfaces 3 Pages: 627-632
  • Peer Reviewed
• [Journal Article] Binding Analysis of Peptides that Recognize Preferentially Cis-Azobenzene Groups of Synthetic Polymers (2011)
  • Author(s): Jing Chen, Takeshi Serizawa, Makoto Komiyama
  • Journal Title: J.Pept.Sci. Volume: 17 Pages: 163-168
  • Peer Reviewed
• [Journal Article] Polymer-binding Peptides for the Noncovalent Modification of Polymer Surfaces : Effects of Peptide Density on the Subsequent Immobilization of Functional Proteins (2011)
  • Author(s): Takaaki Date, Jun Sekine, Hisao Matsuno, Takeshi Serizawa
  • Journal Title: ACS Appl.Mater.Interfaces Volume: 3 Pages: 351-359
  • Peer Reviewed
• [Journal Article] Noncovalent Functionalization of Disentangled Boron Nitride Nanotubes with Flavin Mononucleotides for Strong and Stable Visible-Light Emission in Aqueous Solution (2011)
  • Author(s): Zhenghong Gao, Chunyi Zhi, Yoshio Bando, Dmitri Golberg, Takeshi Serizawa
  • Journal Title: J ACS Appl.Mater.Interfaces Volume: 3 Pages: 627-632
  • Peer Reviewed
• [Journal Article] Detection of Enzyme Activities Based on the Synthesis of Gold Nanoparticles in HEPES Buffer (2010)
  • Author(s): Takeshi Serizawa, Yu Hirai, Mamoru Aizawa
  • Journal Title: Mol.BioSyst. 6 Pages: 1561-1564
  • Peer Reviewed
• [Journal Article] Isolation of Individual Boron Nitride Nanotubes via Peptide Wrapping (2010)
  • Author(s): Zhenghong Gao, Chunyi Zhi, Yoshio Bando, Dmitri Golberg, Takeshi Serizawa
  • Journal Title: J.Am.Chem.Soc. 132 Pages: 4976-4977
  • Peer Reviewed
• [Journal Article] Biological Identification of Peptides that Specifically Bind to Poly(phenylene vinylene) Surfaces : Recognition of the Branched or Linear Structure of the Conjugated Polymer (2010)
  • Author(s): Hirotaka Ejima, Hisao Matsuno, Takeshi Serizawa
  • Journal Title: Langmuir 26 Pages: 17278-17285
  • Peer Reviewed
• [Journal Article] Peptide-Based Switching of Polymer Fluorescence in Aqueous Phase (2010)
  • Author(s): Hirotaka Ejima, Hiromi Kikuchi, Hisao Matsuno, Hirofumi Yajima, Takeshi Serizawa
  • Journal Title: Chem.Mater. 22 Pages: 6032-6034
  • Peer Reviewed
• [Journal Article] Detection of Enzyme Activities Based on the Synthesis of Gold Nanopartitles in HEPES Buffer (2010)
  • Author(s): Takeshi Serizawa, Yu Hirai, Mamoru Aizawa
  • Journal Title: Mol.BioSyst. Volume: 6 Pages: 1561-1564
  • Peer Reviewed
• [Journal Article] Isolation of Individual Boron Nitride Nanotubes via Peptide Wrapping (2010)
  • Author(s): Zhenghong Gao, Chunyi Zhi, Yoshio Bando, Dmitri Golberg, Takeshi Serizawa
  • Journal Title: J.Am.Chem.Soc. Volume: 132 Pages: 4976-4977
  • Peer Reviewed
• [Journal Article] Biological Identification of Peptides that Specifically Bind to Poly (phenylene vinylene) Surfaces : Recognition of the Branched or Linear Structure of the Conjugated Polymer (2010)
  • Author(s): Hirotaka Ejima, Hisao Matsuno, Takeshi Serizawa
  • Journal Title: Langmuir Volume: 26 Pages: 17278-17285
  • Peer Reviewed
• [Journal Article] Peptide-Based Switching of Polymer Fluorescence in Aqueous Phase (2010)
  • Author(s): Hirotaka Ejima, Hiromi Kikuchi, Hisao Matsuno, Hirofumi Yajima, Takeshi Serizawa
  • Journal Title: Chem.Mater. Volume: 22 Pages: 6032-6034
  • Peer Reviewed
• [Journal Article] Novel Synthetic Route to Peptide-Capped Gold Nanoparticles (2009)
  • Author(s): Takeshi Serizawa, Yu Hirai, Mamoru Aizawa
  • Journal Title: Langmuir 25 Pages: 12229-12234
  • Peer Reviewed
• [Journal Article] Adhesion of Two Physically Contacting Planar Substrates Coated with Layer-by-Layer Assembled Films (2009)
  • Author(s): Daisuke Matsukuma, Takao Aoyagi, Takeshi Serizawa
  • Journal Title: Langmuir 25 Pages: 9824-9830
  • Peer Reviewed
• [Journal Article] Water Droplets for the Symmetric Adhesion of Two Poly (methyl methacrylate) Films (2009)
  • Author(s): Takaaki Date, Mizuki Ishikawa, Koichiro Hori, Keiji Tanaka, Toshihiko Nagamura, Makio Iwahashi, Takeshi Serizawa
  • Journal Title: Chem.Lett. 38 Pages: 660-661
  • NAID: 10025123775
  • Peer Reviewed
• [Journal Article] Peptides Recognize Photo-Responsive Material Targets (2009)
  • Author(s): Jing Chen, Takeshi Serizawa, Makoto Komiyama
  • Journal Title: Angew.Chem.Int.Ed. 48 Pages: 2917-2920
  • Peer Reviewed
• [Journal Article] Water Droplets for the Symmetric Adhesion of Two Poly(methyl methacrylate)Films (2009)
  • Author(s): Takaaki Date, Mizuki Ishikawa, Koichiro Hori, Keiji Tanaka, Toshihiko Nagamura, Makio Iwahashi, Takeshi Serizawa
  • Journal Title: Chem.Lett. 38 Pages: 660-661
  • NAID: 10025123775
  • Peer Reviewed
• [Journal Article] Biological Selection of Peptides for Poly(L-lactide) Substrates (2008)
  • Author(s): Hisao Matsuno, Jun Sekine, Hirofumi Yajima, Takeshi Serizawa
  • Journal Title: Langmuir 24 Pages: 6399-6403
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): Takaaki Date, Keiji Tanaka, Toshihiko Nagamura, Takeshi Serizawa
  • Journal Title: Chem.Mater. 20 Pages: 4536-4538
  • Peer Reviewed
• [Journal Article] Directional Affinity of Short Peptides for Synthetic Polymers (2008)
  • Author(s): Takaaki Date, Keiji Tanaka, Tohihiko Nagamura, Takeshi Serizawa
  • Journal Title: Chem. Mater. 20 Pages: 4536-4538
  • Peer Reviewed
• [Presentation] Functional Modification of Soft Interfaces with Polymer-Binding Peptides (2010)
  • Author(s): 芹澤武
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu
  • Year and Date: 2010-12-17
• [Presentation] Isolation and Functionalization of Individual Boron Nitride Nanotubes via Biomolecules Wrapping (2010)
  • Author(s): Zhenghong Gao, Chunyi Zhi, Yoshio Bando, Dmitri Golberg, Takeshi Serizawa
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu
  • Year and Date: 2010-12-17
• [Presentation] Surface Modification of Polymers Using Specific-binding Peptides (2010)
  • Author(s): 伊達隆明, 芹澤武
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu
  • Year and Date: 2010-12-17
• [Presentation] Surface Modification of Polymers Using Specific-binding Peptides (2010)
  • Author(s): Takaaki Date, Takeshi Serizawa
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-12-17
• [Presentation] Isolation and Functionalization of Individual Boron Nitride Nanotubes via Biomolecules Wrapping (2010)
  • Author(s): Zhenghong Gao, Chunyi Zhi, Yoshio Bando, Dmitri Golberg, Takeshi Serizawa
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-12-17
• [Presentation] Functional Modification of Soft Interfaces with Polymer-Binding Peptide (2010)
  • Author(s): Takeshi Serizawa
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu USA
  • Year and Date: 2010-12-17
• [Presentation] Peptides Recognize Synthetic Polymers (2010)
  • Author(s): 芹澤武
  • Organizer: E-MRS 2010 Spring Meeting
  • Place of Presentation: Strasbourg Congress Center
  • Year and Date: 2010-06-11
• [Presentation] Peptides Recognize Synthetic Polymers (2010)
  • Author(s): T.Serizawa
  • Organizer: E-MRS 2010 Spring Meeting
  • Place of Presentation: Strasbourg Congress Center, France
  • Year and Date: 2010-06-11
• [Presentation] 短鎖ペプチドを用いたPMMA薄膜表面の機能化 (2010)
  • Author(s): 松野寿生・吉野里美・伊達隆明・芹澤武
  • Organizer: 第59回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-05-28
• [Presentation] 表面修飾剤としてのエンプラ結合性ペプチド:界面構造が機能発現に及ぼす影響 (2010)
  • Author(s): 伊達隆明・関根淳・松野寿生・芹澤武
  • Organizer: 第59回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-05-28
• [Presentation] ポリマー親和性組換蛋白質の設計と細胞培養制御への応用 (2010)
  • Author(s): 今西優子・吉野祐太・伊達隆明・松野寿生・芹澤武・曽我部敦・黒板敏弘・功刀滋・田中直毅
  • Organizer: 第59回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-05-27
• [Presentation] ペプチドによる共役系高分子の樹状または直鎖構造の認識 (2010)
  • Author(s): 江島広貴・松野寿生・芹澤武
  • Organizer: 第59回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-05-26
• [Presentation] ペプチドによる共役系高分了の樹状または直鎖構造の認識 (2010)
  • Author(s): 江島広貴, 松野寿生, 芹澤武
  • Organizer: 第59回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-05-26
• [Presentation] マテリアル結合性ペプチドの探索と応用 (2010)
  • Author(s): 芹澤武
  • Organizer: 平成21年度高分子学会九州支部フォーラム
  • Place of Presentation: 九州大学
  • Year and Date: 2010-02-12
• [Presentation] Enhanced Adsorption of the Fusion Protein with Polymeric Material-binding Peptide (2009)
  • Author(s): 松野寿生, 田中直毅, 芹澤武
  • Organizer: 第19回日本MRS学術シンポジウム
  • Place of Presentation: 横浜開港記念館
  • Year and Date: 2009-12-09
• [Presentation] Modification of Polymer Softinterfaces with Specific Peptides (2009)
  • Author(s): 芹澤武, 松野寿生
  • Organizer: 第19回日本MRS学術シンポジウム
  • Place of Presentation: 横浜開港記念館
  • Year and Date: 2009-12-07
• [Presentation] Biological Selection of Peptides that Bind to pi-conjugated Polymers (2009)
  • Author(s): 江島広貴, 松野寿生, 芹澤武
  • Organizer: 4th International Symposium on Integrated Molecular/Materials Engineering
  • Place of Presentation: 四川大学
  • Year and Date: 2009-10-27
• [Presentation] Selection of Poly (ether imide)-Binding-Peptides and Their Applications to Surface Modifiers (2009)
  • Author(s): Takaaki Date, Jun Sekine, Hisao Matsuno, Takeshi Serizawa
  • Organizer: 4th International Symposium on Integrated Molecular/Materials Engineering
  • Place of Presentation: 四川大学
  • Year and Date: 2009-10-27
• [Presentation] Selection of Poly(ether imide)-Binding-Peptides and Their Applications to Surface Modifiers (2009)
  • Author(s): 伊達隆明, 関根淳, 松野寿生, 芹澤武
  • Organizer: 4th International Symposium on Integrated Molecular/Materials Engineering
  • Place of Presentation: 中国・四川
  • Year and Date: 2009-10-27
• [Presentation] Biological Selection of Peptides that Bind to pi-conjugated Polymers (2009)
  • Author(s): 江島広貴, 松野寿生, 芹澤武
  • Organizer: 4th International Symposium on Integrated Molecular/Materials Engineering
  • Place of Presentation: 中国・四川
  • Year and Date: 2009-10-27
• [Presentation] 高分子結合性ペプチドを用いた表面修飾:界面構造と機能発現の相関 (2009)
  • Author(s): 伊達隆明・関根淳・松野寿生・芹澤武
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学
  • Year and Date: 2009-09-17
• [Presentation] 交互吸着膜間の接着とそのメカニズム解析 (2009)
  • Author(s): 松隈大輔・芹澤武
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学
  • Year and Date: 2009-09-17
• [Presentation] π共役系高分子結合性ペプチドの探索 (2009)
  • Author(s): 江島広貴・菊池宏海・松野寿生・矢島博文・芹澤武
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学
  • Year and Date: 2009-09-17
• [Presentation] ファージディスプレイ法による共役系高分子結合性ペプチドの探索 (2009)
  • Author(s): 江島広貴・松野寿生・芹澤武
  • Organizer: 第19回バイオ高分子シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2009-07-30
• [Presentation] 高分子結合性ペプチドの探索と医用高分子研究における可能性 (2009)
  • Author(s): 芹澤武・松野寿生
  • Organizer: 第37回医用高分子シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2009-07-28
• [Presentation] ペプチド修飾された高分子表面の構造制御と機能発現 (2009)
  • Author(s): 伊達隆明・関根淳・松野寿生・芹澤武
  • Organizer: 第37回医用高分子シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2009-07-27
• [Presentation] Peptides Specifically Bind to Synthetic Polymers (2009)
  • Author(s): 芹澤武
  • Organizer: NIMS Week
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2009-07-22
• [Presentation] Peptides that Recognize Crystalline PLLA Surface (2009)
  • Author(s): 松野寿生, 芹澤武
  • Organizer: 8th International Symposium on Frontiers in Biomedical Polymers
  • Place of Presentation: 東レ研修センター
  • Year and Date: 2009-05-21
• [Presentation] ペプチド・タンパク質で保護された金ナノ粒子の新規合成法の開発 (2009)
  • Author(s): 平井悠・相澤守・芹澤武
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学
  • Year and Date: 2009-03-27
• [Presentation] Directional Affinity of Polymer-Recognizing Heptapeptides (2008)
  • Author(s): Takaaki Date, Keiji Tanaka, Toshihiko Nagamura, Takeshi Serizawa
  • Organizer: 3rd International Symposium on Integrated Molecular/Materials Engineering
  • Place of Presentation: Northwestern Polytechnical University
  • Year and Date: 2008-11-06
• [Presentation] Directional Affinity of Polymer-Recognizing Heptapeptides (2008)
  • Author(s): Takaaki Date, Keiji Tanaka,Toshihiko Nagamura, Takeshi Serizawa
  • Organizer: 3rd International Symposium on Integrated Molecular/Materials Engineering (ISIMME-3)
  • Place of Presentation: Northwestern Polytechnical University
  • Year and Date: 2008-11-06
• [Presentation] Directional Affinity of Polymer-Recognizing Peptides (2008)
  • Author(s): Takaaki Date, Keiji Tanaka, Toshihiko Nagamura, Takeshi Serizawa
  • Organizer: Japan-Korea Polymer Young Scientist Symposium
  • Place of Presentation: グリーンピア津南
  • Year and Date: 2008-10-24
• [Presentation] 水分子により膨潤したPMMA表面間の接着挙動の解析 (2008)
  • Author(s): 伊達隆明・石川恭希・岩橋槇夫・芹澤武
  • Organizer: 第56回レオロジー討論会
  • Place of Presentation: 新潟コンベンションセンター
  • Year and Date: 2008-10-06
• [Presentation] 高分子電解質多層膜間のナノ接着とそのメカニズム解析 (2008)
  • Author(s): 松隈大輔・芹澤武
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学
  • Year and Date: 2008-09-25
• [Presentation] 水分子により膨潤した薄膜表面間の接着挙動の評価 (2008)
  • Author(s): 伊達隆明・石川恭希・田中敬二・長村利彦・岩橋槇夫・芹澤武
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学
  • Year and Date: 2008-09-25
• [Presentation] 水分子により膨潤した薄膜表面問の接着挙動の評価 (2008)
  • Author(s): 伊達隆明・石川恭希・田中敬二・長村利彦・岩橋槇夫・芹澤武
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学
  • Year and Date: 2008-09-25
• [Presentation] 塩基性ペプチドで保護された金ナノ粒子のOne-pot合成と機能評価 (2008)
  • Author(s): 平井悠・相澤守・芹澤武
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 東京工業大学
  • Year and Date: 2008-09-19
• [Presentation] 塩基性ペプチド修飾金ナノ粒子のOne-pot合成と機能化 (2008)
  • Author(s): 平井悠・相澤守・芹澤武
  • Organizer: 生体機能関連化学若手の会フォーラム
  • Place of Presentation: 東京工業大学
  • Year and Date: 2008-09-17
• [Presentation] 高分子電解質多層膜によるナノ接合メカニズムの解析 (2008)
  • Author(s): 松隈大輔・芹澤武
  • Organizer: 第61回コロイドおよび界面化学討論会
  • Place of Presentation: 九州大学
  • Year and Date: 2008-09-07
• [Presentation] 高分子電解質多層膜によるナノ接合メカニズムの解析 (2008)
  • Author(s): 松隈大輔・芹澤武
  • Organizer: 第61回ココイドおよび界面化学討論会
  • Place of Presentation: 九州大学
  • Year and Date: 2008-09-07
• [Presentation] アゾベンゼンポリマーの異性化を認識するペプチドの探索と特性評価 (2008)
  • Author(s): 陳景・芹澤武・小宮山真
  • Organizer: 第57回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-05-30
• [Presentation] ファージディスプレイ法によるポリエーテルイミド結合性ペプチドの探索 (2008)
  • Author(s): 関根淳・松野寿生・芹澤武
  • Organizer: 第57回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-05-30
• [Presentation] ポリマーステレオコンプレックスに特異結合する短鎖ペプチドの探索 (2008)
  • Author(s): 吉野里美・松野寿生・岩橋槇夫・芹澤武
  • Organizer: 第57回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-05-30
• [Presentation] 高分子電解質多層膜を用いたナノ接着層の構築 (2008)
  • Author(s): 松隈大輔・青柳隆夫・芹澤武
  • Organizer: 第57回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-05-30
• [Presentation] ポリマー二層膜界面におけるナノ接着制御 (2008)
  • Author(s): 伊達隆明・芹澤武
  • Organizer: 第57回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-05-30
• [Presentation] 短鎖ペプチドによるポリ乳酸ステレオコンプレックス表面認識 (2008)
  • Author(s): 松野寿生・芹澤武
  • Organizer: 第57回高分子年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-05-28
• [Remarks] ホームページ等