| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Research Abstract |
Synthesis of copolymers with periodic sequence structure was achieved by two-step polycondensation reaction from 3-hydroxybutyrate and aspartate. When the copolymers reacted with alkyl amine to form ion-complex at side-chain of aspartate units, the enzymatic degradation reaction by polyester-degrading enzyme was inhibited. It was found that the enzymatic degradability of copolymers was regained by the washing under the acidc condition. From the obtained results, we proposed new methodology to control the starting point of biodegradation for the periodic copolymers by changing the pH as outer stimulus.
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