Synthesis of novel periodic copolymers with a function inducing biodegradability as responsive to outer stimulus
| Project/Area Number |
20350072
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental chemistry
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
ABE Hideki The Institute of Physical and Chemical Research, バイオプラスチック研究チーム, チームリーダー (70271541)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
|---|
| Keywords | 周期性共重合体 / 連鎖構造制御 / 生分解性 / 3-ヒドロキシブタン酸 / スイッチ機能 / 重縮合 / イオンコンプレックス / 周期共重合体 / 酵素分解 / 側鎖長効果 / 分子鎖末端活性化処 |
|---|
| Research Abstract |
Synthesis of copolymers with periodic sequence structure was achieved by two-step polycondensation reaction from 3-hydroxybutyrate and aspartate. When the copolymers reacted with alkyl amine to form ion-complex at side-chain of aspartate units, the enzymatic degradation reaction by polyester-degrading enzyme was inhibited. It was found that the enzymatic degradability of copolymers was regained by the washing under the acidc condition. From the obtained results, we proposed new methodology to control the starting point of biodegradation for the periodic copolymers by changing the pH as outer stimulus.
|
Report
(4 results)
Research Products
(16 results)
