| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
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| Research Abstract |
Erythropoietin analogue and co-stimulate glycoprotein were synthesized. In addition to these results, glycosylated polypeptide chain of IgG-Fc region was also synthesized. In order to synthesize glycoproteins, glycopeptides-thioesters were prepared by chemical method and polypeptide chain was prepared from E. Coli expression method. Coupling both peptides to prepare whole glycosylated polypeptide and subsequent folding process afforded the folded glycoproteins.
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