| Budget Amount *help |
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Research Abstract |
Process and mechanism in the functional adaptation of superficial zone tissue structure of articular cartilage to tribological stimulations was explored. A well established three dimensional culture system for isolated chondrocytes, chondrocyte-agarose construct, was employed as a regenerated cartilage model and mechanical stimulations, such as cyclic compression, shear and surface friction, were applied to the model to examine their effects on cell metabolisms and the subsequent development of functional tissue structure for joint lubrication.
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