Development of functional surface structure and lubrication ability in articular cartilage tissue under tribologycal stimulation
| Project/Area Number |
20360078
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Design engineering/Machine functional elements/Tribology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
SAWAE Yoshinori Kyushu University, 大学院・工学研究院, 教授 (10284530)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WATANABE Masao 北海道大学 (30274484)
SAKAI Nobuo 九州工業大学 (60346814)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
|
|---|
| Keywords | トライボロジー / 細胞・組織 / 関節軟骨 / 潤滑機能 / 移植・再生医療 |
|---|
| Research Abstract |
Process and mechanism in the functional adaptation of superficial zone tissue structure of articular cartilage to tribological stimulations was explored. A well established three dimensional culture system for isolated chondrocytes, chondrocyte-agarose construct, was employed as a regenerated cartilage model and mechanical stimulations, such as cyclic compression, shear and surface friction, were applied to the model to examine their effects on cell metabolisms and the subsequent development of functional tissue structure for joint lubrication.
|
Report
(4 results)
Research Products
(50 results)
