Ion transport control of cell membrane by developing sensing technique using evanescent wave for refractive index and electrostatic potential of cell
| Project/Area Number |
20360102
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thermal engineering
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| Research Institution | Keio University |
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Principal Investigator |
SATO Yohei Keio University, 理工学部, 准教授 (00344127)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Toshiyuki 慶應義塾大学, 理工学部, 教授 (00255598)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | マイクロ流体デバイス / 細胞表面電位 / 細胞内屈折率 / エバネッセント波 / マイクロPIV / マイクロLIF / 細胞膜 / 二波長 / ナノLIF / アイクロPIV |
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| Research Abstract |
A non-invasive sensing technique using evanescent wave for the refractive index and electrostatic potential of cell was developed in order to control ion transport between cell and culture solution in microfluidic device. A novel technique to detect refractive index difference was proposed utilizing light scattering by evanescent wave illumination. A color imaging of electrostatic potential distribution was achieved by developing a two-color LIF technique.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy2009
Author(s)
Eisuke Adachi, Yutaka Kazoe, Yohei Sato, Yuko Suzuki, Tetsumei Urano, Takehiko Ueyama, Naoaki Saito, Viacheslav O.Nikolaev, Martin J.Lohse, Makoto Tominaga, Hideo Mogami
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Journal Title
Pflugers Archiv-European Journal of Physiology 459
Pages: 227-234
Related Report
Peer Reviewed
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