A Study on Noninvasive Ultrasonic Measurement of Minute Mechanical-Excitation Wave-front Propagation in Human Myocardial Tissue and Its Visualization
| Project/Area Number |
20360181
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Measurement engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
KANAI Hiroshi 東北大学, 大学院・工学研究科, 教授 (10185895)
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| Co-Investigator(Kenkyū-buntansha) |
SAIJO Yoshifumi 東北大学, 大学院・医工学研究科, 教授 (00292277)
HASEGAWA Hideyuki 東北大学, 大学院・医工学研究科, 准教授 (00344698)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 心臓疾患 / 医用超音波工学 / 心臓壁弾性特性 / 位相差トラッキング法 / 電気的興奮伝搬 / 合成開口法 / 三次元表示 / 心筋収縮弛緩特性 / 合成開口洪 |
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| Research Abstract |
Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured based on the electro-magnetic phenomena. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions, the present study shows that the propagation of the mechanical wave-front occurs at the beginning of cardiac contraction sequence for the first time (about 60 ms prior to the ordinarily accepted onset time of the contraction). From the apical side of the interventricular septum, a minute velocity component with an amplitude of several tenth micrometers is generated and it propagates from the apex to the base of the posterior wall, and then from the base to the apex of the septum, with a propagation speed of 3-9 m/s. This dynamic measurement modality is also applicable to various tissues in biology.
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Report
(4 results)
Research Products
(94 results)
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[Journal Article] Carotid Arterial Elasticity is a Sensitive Atherosclerosis Value Reflecting Visceral Fat Accumulation in Obese subjects2009
Author(s)
Ai Tokita, Yasushi Ishigaki, Hisashi Okimoto, Hideyuki Hasegawa, Yoshiro Koiwa, Makoto Kato, Hisamitsu Ishihara, Yoshinori Hinokio, Hideki Katagiri, Hiroshi Kanai, Yoshitomo Oka
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Journal Title
Atherosclerosis
Volume: 206巻
Pages: 168-172
Related Report
Peer Reviewed
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[Presentation] LPUS : Labile Platform for Ultrasound System2011
Author(s)
Takaya Uno, Hiroshi Kanai
Organizer
16th International Symposium of Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and Research Network Centre
Place of Presentation
Sendai
Year and Date
2011-03-22
Related Report
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[Presentation] LPUS : Labile Platform for Ultrasound System2011
Author(s)
Takaya Uno, Hiroshi Kanai
Organizer
16th International Symposium of Tohoku University Global COE Program "Global Nano-Biomedical Engineering Education and Research Network Centre"
Place of Presentation
Sendai
Year and Date
2011-03-22
Related Report
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