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Development of transgenic avian platform for the production of biologics

Research Project

Project/Area Number 20360376
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biofunction/Bioprocess
Research InstitutionKyushu University

Principal Investigator

KAMIHIRA Masamichi  Kyushu University, 工学研究院, 教授 (40202022)

Co-Investigator(Kenkyū-buntansha) KAWABE Yoshinori  九州大学, 工学研究院, 助教 (30448401)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywords生物・生体工学 / バイオテクノロジー / トランスジェニック鳥類 / バイオロジクス / ウイルスベクター
Research Abstract

Transgenic chicken bioreactor systems were developed for the production of pharmaceutical proteins using the avian transgenic technology. In the present study, development of oviduct-specific gene expression systems, control strategy for sugar chain modification of glycoprotein products, and biologics production suitable for transgenic chicken bioreactors were examined to establish the procedure as a biologics production system.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (36 results)

All 2011 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 3 results) Presentation (22 results) Remarks (1 results)

  • [Journal Article] Production of Antibody in Transgenic Avians2011

    • Author(s)
      Y.Kawabe, M.Kamihira
    • Journal Title

      Antibody Engineering and Production (Cell Engineering, Vol.7)

      Volume: 7(印刷中)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Production of recombinant human erythropoietin/Fc fusion protein by genetically manipulated chickens2010

    • Author(s)
      C.A.Penno, Y.Kawabe, A.Ito, M.Kamihira
    • Journal Title

      Transgenic Research Vol.19, No.2

      Pages: 187-195

    • NAID

      120005289502

    • Related Report
      2010 Final Research Report
  • [Journal Article] Production of recombinant human EPO and EPO/Fc fusion proteins by Chinese hamster ovary cells2010

    • Author(s)
      C.A.Penno, Y.Kawabe, A.Ito, M.Kamihira
    • Journal Title

      Animal Cell Technology : Basic & Applied Aspects, Springer Vol.16

      Pages: 197-202

    • Related Report
      2010 Final Research Report
  • [Journal Article] Development of oviduct-specific gene expression system for transgenic avian bioreactor2010

    • Author(s)
      Y.Kawabe, K.Numata, M.Teramori, A.Ito, M.Kamihira
    • Journal Title

      Animal Cell Technology : Basic & Applied Aspects, Springer Vol.16

      Pages: 203-208

    • Related Report
      2010 Final Research Report
  • [Journal Article] Production of therapeutic proteins composed of seven dominant human T cell epitopes derived from the Japanese cedar pollen allergens2010

    • Author(s)
      Y.Kawabe, Y.Hayashida, K.Numata, A.Hishigae, A.Ito, M.Kamihira
    • Journal Title

      Animal Cell Technology : Basic & Applied Aspects, Springer Vol.16

      Pages: 209-214

    • Related Report
      2010 Final Research Report
  • [Journal Article] Production of recombinant human erythropoietin/Fc fusion protein by genetically manipulated chickens2010

    • Author(s)
      C.A.Penno, Y.Kawabe, A.Ito, M.Kamihira
    • Journal Title

      Transgenic Research 19

      Pages: 187-195

    • NAID

      120005289502

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of oviduct-specific gene expression system for transgenic avian bioreactor2010

    • Author(s)
      Y.Kawabe, K.Numata, M.Teramori, A.Ito, M.Kamihira
    • Journal Title

      Animal Cell Technology : Basic & Applied Aspects 16

      Pages: 203-208

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Production of therapeutic proteins composed of seven dominant human T cell epitopes derived from the Japanese cedar pollen allergens2010

    • Author(s)
      Y.Kawabe, Y.Hayashida, K.Numata, A.Hishigae, A.Ito, M.Kamihira
    • Journal Title

      Animal Cell Technology : Basic & Applied Aspects 16

      Pages: 209-214

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Production of chimeric monoclonal antibodies by genetically manipulated chickens2009

    • Author(s)
      M.Kamihira, Y.Kawabe, T.Shindo, K.Ono, K.Esaka, T.Yamashita, K.Nishijima, S.Iijima
    • Journal Title

      Journal of Biotechnology Vol.141, No.1-2

      Pages: 18-25

    • Related Report
      2010 Final Research Report
  • [Journal Article] Production of chimeric monoclonal antibodies by genetically manipulated chickens2009

    • Author(s)
      M. Kamihira, et al.
    • Journal Title

      Journal of Biotechnology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retroviral gene transduction into chicken embryo gonads through blood circulation2008

    • Author(s)
      Y.Kawabe, T.Naka, H.Komatsu, K.Nishijima, S.Iijima, M.Kamihira
    • Journal Title

      Journal of Bioscience and Bioengineering Vol.106, No.6

      Pages: 598-601

    • NAID

      110007021801

    • Related Report
      2010 Final Research Report
  • [Journal Article] Retroviral gene transduction into chicken embryo gonads through blood circulation2008

    • Author(s)
      Y. Kawabe, et al.
    • Journal Title

      Journal of Bioscience and Bioengineering 106

      Pages: 598-601

    • NAID

      110007021801

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of Antibody by Transgenic Avians (Chapter 6)

    • Author(s)
      Y.Kawabe, M.Kamihira
    • Journal Title

      Antibody Engineering and Production (Cell Engineering), Springer Vol.7 印刷中

    • Related Report
      2010 Final Research Report
  • [Presentation] スギ花粉症治療用タンパク質を生産する遺伝子導入ニワトリの作製2011

    • Author(s)
      上平正道, 林田悠希, 沼田健作, 原田翔太, 河邉佳典, 井藤彰
    • Organizer
      日本農芸化学会2011大会
    • Place of Presentation
      京都女子大学(開催中止)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] スギ花粉症治療用タンパク質を生産する遺伝子導入ニワトリの作製2011

    • Author(s)
      上平正道, 林田悠希, 沼田健作, 原田翔太, 河邉佳典, 井藤彰
    • Organizer
      日本農芸化学会2011大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 遺伝子導入ニワトリが生産したスギ花粉症治療用エピトープペプチド含有卵の効能評価2011

    • Author(s)
      河邉佳典, 林田悠希, 原田翔太, 沼田健作, 井藤彰, 上平正道
    • Organizer
      化学工学会第76年会
    • Place of Presentation
      東京農工大学(開催中止)
    • Year and Date
      2011-03-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 遺伝子導入ニワトリが生産したスギ花粉症治療用エピトープペプチド含有卵の効能評価2011

    • Author(s)
      河邉佳典, 林田悠希, 原田翔太, 沼田健作, 井藤彰, 上平正道
    • Organizer
      化学工学会第76年会
    • Place of Presentation
      東京農工大学
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 合成プロモーターを用いたニワトリ卵管特異的発現システムの解析2010

    • Author(s)
      黒原健志, 沼田健作, 河邉佳典, 井藤彰, 上平正道
    • Organizer
      第62回日本生物工学会大会
    • Place of Presentation
      宮崎シーガイア
    • Year and Date
      2010-09-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 合成プロモーターを用いたニワトリ卵管特異的発現システムの解析2010

    • Author(s)
      黒原健志, 沼田健作, 河邉佳典, 井藤彰, 上平正道
    • Organizer
      第62回日本生物工学会大会
    • Place of Presentation
      フェニックス・シーガイア・リゾート
    • Year and Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 遺伝子導入ニワトリによるスギ花粉症治療用エピトープ融合リゾチームの生産2010

    • Author(s)
      林田悠希, 沼田健作, 山田紀子, 河邉佳典, 井藤彰, 上平正道
    • Organizer
      化学工学会第42回秋季大会
    • Place of Presentation
      同志社大学
    • Year and Date
      2010-09-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 遺伝子導入ニワトリによるスギ花粉症治療用エピトープ融合リゾチームの生産2010

    • Author(s)
      林田悠希, 沼田健作, 山田紀子, 河邉佳典, 井藤彰, 上平正道
    • Organizer
      化学工学会第42回秋季大会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2010-09-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 合成プロモーターシステムによる卵管特異的高発現の誘導2009

    • Author(s)
      山元秀晃, 沼田建作, 寺森正志, 河邉佳典, 井藤彰, 上平正道
    • Organizer
      第2回化学工学3支部合同北九州大会
    • Place of Presentation
      西日本総合展示場(北九州)
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 遺伝子導入ニワトリによるスギ花粉症治療用エピトープペプチド含有タンパク質の生産2009

    • Author(s)
      沼田健作, 山田紀子, 林田義文, 河邉佳典, 井藤彰, 上平正道
    • Organizer
      生物工学会平成21年度大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2009-09-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ニワトリ卵管特異的高発現のための合成プロモーターシステムの開発2009

    • Author(s)
      山元秀晃, 沼田建作, 寺森正志, 河邉佳典, 井藤彰, 上平正道
    • Organizer
      生物工学会平成21年度大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2009-09-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] スギ花粉症治療のためのエピトープ含有タンパク質を生産する遺伝子導入ニワトリの作製2009

    • Author(s)
      山田紀子, 沼田健作, 林田義文, 河邉佳典, 井藤彰, 上平正道
    • Organizer
      化学工学会第41回秋季大会
    • Place of Presentation
      広島大学
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 遺伝子導入鳥類による組換えタンパク質生産2009

    • Author(s)
      上平正道
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2009-03-29
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 遺伝子組換えニワトリが生産したFc融合型ヒトエリスロポイエチンの解析2009

    • Author(s)
      河邉佳典, ペーノ カルロス, 井藤彰, 上平正道
    • Organizer
      化学工学会第74年会
    • Place of Presentation
      横浜国立大学
    • Year and Date
      2009-03-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of oviduct-specific gene expression system for transgenic avian bioreactors2008

    • Author(s)
      K.Numata, Y.Kawabe, M.Teramori, A.Ito, M.Kamihira
    • Organizer
      日本動物細胞工学会2008国際大会(JAACT2008)
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Production of therapeutic proteins composed of seven dominant human T cell epitopes derived from the Japanese cedar pollen allergens2008

    • Author(s)
      Y.Hayashida, Y.Kawabe, K.Numata, A.Hishigae, A.Ito, M.Kamihira
    • Organizer
      日本動物細胞工学会2008国際大会(JAACT2008)
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Generation of genetically manipulated chickens producing human erythropoietin/Fc fusion protein2008

    • Author(s)
      C.A.Penno, Y.Kawabe, A.Ito, M.Kamihira
    • Organizer
      日本動物細胞工学会2008国際大会(JAACT2008)
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of oviduct-specific gene expression system for transgenic avianbioreactor2008

    • Author(s)
      K. Numata, Y. Kawabe, M. Teramori, A. Ito, M. Kamihira
    • Organizer
      日本動物細胞工学会2008国際大会(JAACT2008)
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-11-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 合成プロモーターを組込んだニワトリ卵管特異的発現システムの開発2008

    • Author(s)
      沼田健作, 寺森正志, 河邉佳典, 井藤彰, 上平正道
    • Organizer
      生物工学会平成20年度大会
    • Place of Presentation
      東北学院大学土樋キャンパス
    • Year and Date
      2008-08-28
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 遺伝子組換えニワトリによるヒトエリスロポエチンFc融合タンパク質の生産2008

    • Author(s)
      河邉佳典, ペーノ カルロス, 井藤彰, 上平正道
    • Organizer
      化学工学会九州支部沖縄大会
    • Place of Presentation
      沖縄産業支援センター
    • Year and Date
      2008-08-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Generation of transgenic chickens for the production of human erythropoietin/Fc fusion protein2008

    • Author(s)
      C.A.Penno, Y.Kawabe, A.Ito, M.Kamihira
    • Organizer
      第45回化学関連支部合同九州大会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2008-07-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 花粉症治療用エピトープペプチド含有タンパク質を生産するトランスジェニック鳥類の作製2008

    • Author(s)
      沼田健作, 林田義文, 河邉佳典, 井藤彰, 上平正道
    • Organizer
      第45回化学関連支部合同九州大会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2008-07-05
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.chem-eng.kyushu-u.ac.jp/lab3/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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