| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
Homologous recombination plays a role in chromosome segregation during meiosis as well as production of genome diversity. Meiotic recombination is coupled with the formation of an unique chromosome structure referred as to the Synaptonemal complex. Not only the formation of the unique chromosome structures, but also meiosis shows chromosome motion and rearrangement of chromosomes inside a nucleus. In this study, we showed that the formation of synaptonemal complex and chromosome motion is regulated by phosphorylation of a nuclear envelope protein, Mps3. This suggests the novel role of nuclear envelop in respect of chromosome functions.
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