Regulation of microtubule cytoskeleton by phosphorylation
Project/Area Number |
20370023
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Plant molecular biology/Plant physiology
|
Research Institution | Nara Institute of Science and Technology |
Principal Investigator |
HASHIMOTO Takashi Nara Institute of Science and Technology, バイオサイエンス研究科, 教授 (80180826)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 微小管 / リン酸化 / フォスファターゼ / キナーゼ / アラビドプシス / アラピドプシス / シグナル伝達 / 植物 |
Research Abstract |
Phosphorylation of plant microtubules was investigated with respects to tubulin phosphorylation and protein phosphatases. I found that the Arabidopsis Propyzamide-Hypersensitive 1 protein of the mitogen-activated protein kinase phosphatase family also possesses a kinase domain of atypical protein kinases. The kinase activity is suppressed by the intra-molecular phosphatase activity, but when this suppression is removed, the activated kinase rapidly phosphorylates tubulin and depolymerizes cortical microtubules.
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Report
(4 results)
Research Products
(37 results)