Physiological and pathological roles of CD47-SHPS-1 system
Project/Area Number |
20370044
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Functional biochemistry
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Research Institution | Gunma University |
Principal Investigator |
MATOZAKI Takashi Gunma University, 生体調節研究所, 客員教授 (80252782)
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Co-Investigator(Kenkyū-buntansha) |
OHNISHI Hiroshi 群馬大学, 生体調節研究所, 准教授 (70334125)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
Keywords | シグナル伝達学 / 生体分子学 / 蛋白質 / 脳・神経 / 免疫学 / 生体分子 / シグナル伝達 |
Research Abstract |
SHPS-1 and CD47 are transmembrane proteins and they constitute a cell-cell communication system by interacting their ectodomains. In this research project, we have shown that CD47-SHPS-1 system participates in regulation of brain stress response and depression-like behavior as well as induction of IL-17-producing helper T cells and autoimmune diseases. In addition, it also plays an important role in regulation of insulin secretion from pancreatic βcells.
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Report
(4 results)
Research Products
(91 results)
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[Journal Article] Role of SIRPa in regulation of mucosal immunity in the intestine.2010
Author(s)
Kanazawa Y., Saito Y., Supriatna Y., Tezuka H., Kotani T., Murata Y., Okazawa H., Ohnishi H., Kinouchi Y., Nojima Y., Ohteki T., Shimosegawa T., Matozaki T.
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Journal Title
Genes Cells 15
Pages: 1189-1200
Related Report
Peer Reviewed
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[Journal Article] Regulation by SIRPa of dendritic cell homeostasis in lymphoid tissues.2010
Author(s)
Saito Y., Iwamura H., Kaneko T., Ohnishi H., Murata Y., Okazawa H., Kanazawa Y., Sato-Hashimoto M., Kobayashi H., Oldenborg P.-A., Naito M., Kaneko Y., Nojima Y., Matozaki T.
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Journal Title
Blood 116
Pages: 3517-3525
Related Report
Peer Reviewed
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[Journal Article] Stress-evoked tyrosine phosphorylation of SIRPa regulates behavioral immobility in the forced swim test.2010
Author(s)
Ohnishi H., Murata T., Kusakari S., Hayashi Y., Takao K., Maruyama T., Ago Y., Koda K., Jin F.-J., Okawa K., Oldenborg P.-A., Okazawa H., Murata Y., Furuya N., Matsuda T., Miyakawa T., Matozaki T.
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Journal Title
J.Neuroscl. 30
Pages: 10472-10483
Related Report
Peer Reviewed
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[Journal Article] Resistance to collagen-induced arthritis in SHPS-1 mutant mice.2008
Author(s)
Okuzawa C., Kaneko Y., Murata Y., Miyake A., Saito Y., Okajo J., Tomizawa T., Kaneko Y., Okazawa H., Ohnishi H., Matozaki T., Nojima Y.
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Journal Title
Biochem. Biophys.Res.Commun. 371
Pages: 561-566
Related Report
Peer Reviewed
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[Presentation] Stress-evoked tyrosine phosphorylation of SIRPa mediates an antidepressant effect.2010
Author(s)
Ohnishi H., Kusakari S., Murata T., Hayashi Y., Maruyama T., Okazawa H., Murata Y., Takao K., Miyakawa T., Oldenborg P.-A., Matozaki T.
Organizer
40th Annual Meeting of Society for Neuroscience.
Place of Presentation
San Diego Convention Center (USA, San Diego)
Related Report
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[Presentation] Regulation by SIRPa of homeostasis of lymphoid tissue dendritic cells.2010
Author(s)
Saito Y., Iwamura H., Kaneko T., Kanazawa Y., Sato-Hashimoto M., Murata Y., Ohnishi H., Kaneko Y., Nojima, Y., Matozaki T.
Organizer
14th International Congress of Immunology
Place of Presentation
神戸ポートアイランド(兵庫)
Related Report
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