Physiological and pathological roles of CD47-SHPS-1 system

• Project/Area Number: 20370044
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Gunma University
• Principal Investigator: MATOZAKI Takashi Gunma University, 生体調節研究所, 客員教授 (80252782)
• Co-Investigator(Kenkyū-buntansha): OHNISHI Hiroshi 群馬大学, 生体調節研究所, 准教授 (70334125)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000); Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: シグナル伝達学 / 生体分子学 / 蛋白質 / 脳・神経 / 免疫学 / 生体分子 / シグナル伝達

Research Abstract

SHPS-1 and CD47 are transmembrane proteins and they constitute a cell-cell communication system by interacting their ectodomains. In this research project, we have shown that CD47-SHPS-1 system participates in regulation of brain stress response and depression-like behavior as well as induction of IL-17-producing helper T cells and autoimmune diseases. In addition, it also plays an important role in regulation of insulin secretion from pancreatic βcells.

Research Products

• [Journal Article] Essential roles of SIRPα in homeostatic regulation of skin dendritic cells. (2011)
  • Author(s): Iwamura, H., et al.
  • Journal Title: Immunol. Lett. Volume: 135 Pages: 100-107
  • Peer Reviewed
• [Journal Article] Requirement of SIRPa for protective immunity against leishmania major. (2010)
  • Author(s): Morimoto N., Murata Y., Motegi S., Suzue K..Saito Y..Okazawa H., Ohnishi H., Kotani T., Kusakari S., Ishikawa O., Matozaki T.
  • Journal Title: Biochem.Biophys.Res.Commun. 401 Pages: 385-389
  • Peer Reviewed
• [Journal Article] Role of SIRPa in regulation of mucosal immunity in the intestine. (2010)
  • Author(s): Kanazawa Y., Saito Y., Supriatna Y., Tezuka H., Kotani T., Murata Y., Okazawa H., Ohnishi H., Kinouchi Y., Nojima Y., Ohteki T., Shimosegawa T., Matozaki T.
  • Journal Title: Genes Cells 15 Pages: 1189-1200
  • Peer Reviewed
• [Journal Article] Regulation by SIRPa of dendritic cell homeostasis in lymphoid tissues. (2010)
  • Author(s): Saito Y., Iwamura H., Kaneko T., Ohnishi H., Murata Y., Okazawa H., Kanazawa Y., Sato-Hashimoto M., Kobayashi H., Oldenborg P.-A., Naito M., Kaneko Y., Nojima Y., Matozaki T.
  • Journal Title: Blood 116 Pages: 3517-3525
  • Peer Reviewed
• [Journal Article] Stress-evoked tyrosine phosphorylation of SIRPa regulates behavioral immobility in the forced swim test. (2010)
  • Author(s): Ohnishi H., Murata T., Kusakari S., Hayashi Y., Takao K., Maruyama T., Ago Y., Koda K., Jin F.-J., Okawa K., Oldenborg P.-A., Okazawa H., Murata Y., Furuya N., Matsuda T., Miyakawa T., Matozaki T.
  • Journal Title: J.Neuroscl. 30 Pages: 10472-10483
  • Peer Reviewed
• [Journal Article] Stress-evoked tyrosine phosphorylation of SIRPα regulates behavioral immobility in the forced swim test. (2010)
  • Author(s): Ohnishi, H., et al.
  • Journal Title: J.Neurosci. Volume: 30 Pages: 10472-10483
  • Peer Reviewed
• [Journal Article] Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues (2010)
  • Author(s): Saito, Y., et al.
  • Journal Title: Blood Volume: 116 Pages: 3517-3525
  • Peer Reviewed
• [Journal Article] Expression of PTPRO in the interneurons of adult mouse olfactory bulb. (2010)
  • Author(s): Kotani, T., et al.
  • Journal Title: J.Comp.Neurol. Volume: 518 Pages: 119-136
  • Peer Reviewed
• [Journal Article] Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins. (2010)
  • Author(s): Mori, M., et al.
  • Journal Title: J.Cell.Physiol. Volume: 224 Pages: 195-204
  • Peer Reviewed
• [Journal Article] Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn. (2010)
  • Author(s): Murata, Y., et al.
  • Journal Title: Genes Cells Volume: 15 Pages: 513-524
  • Peer Reviewed
• [Journal Article] Role of SIRPα in regulation of mucosal immunity in the intestine. (2010)
  • Author(s): Kanazawa, Y., et al.
  • Journal Title: Genes Cells Volume: 15 Pages: 1189-1200
  • Peer Reviewed
• [Journal Article] Requirement of SIRPα for protective immunity against Leishmania maior. (2010)
  • Author(s): Morimoto, N., et al.
  • Journal Title: Biochemical Biophysical Research Communication Volume: 401 Pages: 385-389
  • Peer Reviewed
• [Journal Article] Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals. (2010)
  • Author(s): Matozaki T., et al.
  • Journal Title: Cellular Signal. Volume: 22 Pages: 1811-1817
  • Peer Reviewed
• [Journal Article] Expression of PTPRO in the interneurons of adult mouse olfactory bulb (2010)
  • Author(s): Kotani, T., 他
  • Journal Title: J.Comp.Neurol. 518 Pages: 119-136
  • Peer Reviewed
• [Journal Article] Functions and molecular mechanisms of the CD47-SIRPa signalling pathway. (2009)
  • Author(s): Matozaki T., Murata Y., Okazawa H., Ohnishi H.
  • Journal Title: Trends Cell Biol.(Review) 19 Pages: 72-80
  • Peer Reviewed
• [Journal Article] Inhibitory regulation of osteoclast bone resorption by SIRPa. (2009)
  • Author(s): van Beek E.M., de Vries T.J., Mulder L., Schoenmaker T., Hoeben K.A., Matozaki T., Langenbach G.E.J., Kraal G., Everts V., van den Berg T.K.
  • Journal Title: FASEB J. 23 Pages: 4081-4090
  • Peer Reviewed
• [Journal Article] Inhibitory regulation of osteoclast bone resorption by SIRPα (2009)
  • Author(s): van Beek, E.M., 他
  • Journal Title: FASEBJ. 23 Pages: 4081-4190
  • Peer Reviewed
• [Journal Article] Signal regulatory protein-bl : a microglial modulator of phagocytosis in Alzheimer's disease (2009)
  • Author(s): Gaikwad, S., 他
  • Journal Title: AM.J., Pathol 175 Pages: 2528-2539
  • Peer Reviewed
• [Journal Article] Functions and molecular mechanisms of the CD47-SIRPα signalling pathway (2009)
  • Author(s): Matozaki, T., 他
  • Journal Title: Trends Cell Biol. 19 Pages: 72-80
  • Peer Reviewed
• [Journal Article] Protein tyrosine phosphatase SHP-2 : A proto-oncogene product that promotes Ras activation (2009)
  • Author(s): Matozaki, T., 他
  • Journal Title: Cancer Sci. 100 Pages: 1786-1793
  • NAID: 10027195202
  • Peer Reviewed
• [Journal Article] Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic β-cells and its roles in promotion of insulin secretion and protection against diabetes. (2008)
  • Author(s): Kobayashi M., Ohnishi H., Okazawa H., Murata Y., Hayashi Y., Kobayashi H., Kitamura T., Matozaki T.
  • Journal Title: Endocrinology 149 Pages: 5662-5669
  • Peer Reviewed
• [Journal Article] Resistance to collagen-induced arthritis in SHPS-1 mutant mice. (2008)
  • Author(s): Okuzawa C., Kaneko Y., Murata Y., Miyake A., Saito Y., Okajo J., Tomizawa T., Kaneko Y., Okazawa H., Ohnishi H., Matozaki T., Nojima Y.
  • Journal Title: Biochem. Biophys.Res.Commun. 371 Pages: 561-566
  • Peer Reviewed
• [Journal Article] Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages. (2008)
  • Author(s): Miyake A., Murata Y., Okazawa H., Ikeda H., Niwayama Y., Ohnishi H., Hirata Y., Matozaki T.
  • Journal Title: Genes Cells 13 Pages: 209-219
  • Peer Reviewed
• [Journal Article] Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system. (2008)
  • Author(s): Kusakari S., Ohnishi H., Jin F.-J., Kaneko Y., Murata T., Murata Y., Okazawa H., Matozaki T.
  • Journal Title: J.Cell Sci. 121 Pages: 1213-1223
  • Peer Reviewed
• [Journal Article] Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system. (2008)
  • Author(s): Kusakari, S.,他
  • Journal Title: J. Cell Sci. 121 Pages: 1213-1223
  • Peer Reviewed
• [Journal Article] Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages. (2008)
  • Author(s): Miyake, A.,他
  • Journal Title: Genes Cells 13 Pages: 209-219
  • Peer Reviewed
• [Journal Article] Resistance to collagen-induced arthritis in SHPS-1 mutant mice. (2008)
  • Author(s): Okuzawa, C.,他
  • Journal Title: Biochem. Biophys. Res. Commun. 371 Pages: 561-566
  • Peer Reviewed
• [Journal Article] Expressibn of Src homology 2 domain-containing protein tyrosine, phosphatase substrate-1 in pancreatic β-cells and its roles in promotion of insulin secretion and protection against diabetes. (2008)
  • Author(s): Kobayashi,M. 他
  • Journal Title: Endocrinology 149 Pages: 5662-5669
  • Peer Reviewed
• [Journal Article] Essential roles of SHPS-1 in induction of contacthypersensitivity of skin. (2008)
  • Author(s): Motegi, S. 他
  • Journal Title: Immunol. Lett. 121 Pages: 52-60
  • Peer Reviewed
• [Journal Article] Impaired proliferation and Thl differentiation of CD4+ T cells in SHPS-1 mutant mice. (2008)
  • Author(s): Kaneko, Y., 他
  • Journal Title: Kitakanto Med. J. 58 Pages: 133-139
  • Peer Reviewed
• [Journal Article] Structural insight into the specific interaction between murineSHPS-1/SIRPα and itsl igandCD47. (2008)
  • Author(s): Nakaishi, A., 他
  • Journal Title: J.Mo1.Bio1 375 Pages: 650-660
  • Peer Reviewed
• [Journal Article] Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. (2008)
  • Author(s): Kuroda, S., 他
  • Journal Title: Eur. J. Immunol. 38 Pages: 1331-1340
  • Peer Reviewed
• [Journal Article] SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis. (2008)
  • Author(s): Sadakata, H., 他
  • Journal Title: Genes Cells 14 Pages: 292-308
  • Peer Reviewed
• [Journal Article] Functions and molecular mechanisms of the CD47-SIRPa signalling pathway. (2008)
  • Author(s): Matozaki, T., 他
  • Journal Title: Trends Cell Biol. 19 Pages: 72-80
  • Peer Reviewed
• [Journal Article] Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase(VE-PTP)in cooperation with integrins
  • Author(s): Mori, M., 他
  • Journal Title: J.Cell.Physiol. (in press)
  • Peer Reviewed
• [Journal Article] Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn
  • Author(s): Murata, Y., 他
  • Journal Title: Genes Cells (in press)
  • Peer Reviewed
• [Presentation] Regulation of intestinal immunity by SAP-1, a microvillus-specific receptor-type protein tyrosine phosphatase (2011)
  • Author(s): Matozaki, T.
  • Organizer: 第9回プロテインホスファターゼ国際カンファレンス
  • Place of Presentation: 東京大学本郷キャンパス鉄門記念講堂
  • Year and Date: 2011-02-03
• [Presentation] 血管内皮細胞のシェアストレス刺激応答におけるVE-PTPの機能解析 (2010)
  • Author(s): 村田陽二、的崎尚, 他
  • Organizer: BMB2010第33回日本分子生物学会年会第83回日本生化学会大会 合同年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-10
• [Presentation] Stress-evoked tyrosine phosphorylation of SIRPa mediates an antidepressant effect. (2010)
  • Author(s): Ohnishi H., Kusakari S., Murata T., Hayashi Y., Maruyama T., Okazawa H., Murata Y., Takao K., Miyakawa T., Oldenborg P.-A., Matozaki T.
  • Organizer: 40th Annual Meeting of Society for Neuroscience.
  • Place of Presentation: San Diego Convention Center (USA, San Diego)
• [Presentation] チロシンリン酸化シグナルによる脳のストレス応答制御 (2010)
  • Author(s): 大西浩史、草苅伸也、村田考啓、丸山登士、林由里子、高雄啓三、宮川剛、吾郷由希夫、香田健、松田敏夫、大川克也、齊藤泰之、村田陽二、的崎尚
  • Organizer: 第33回日本神経科学大会、第53回日本神経化学会大会、第20回日本神経回路学会大会、合同大会
  • Place of Presentation: 兵庫
• [Presentation] Regulation by SIRPa of homeostasis of lymphoid tissue dendritic cells. (2010)
  • Author(s): Saito Y., Iwamura H., Kaneko T., Kanazawa Y., Sato-Hashimoto M., Murata Y., Ohnishi H., Kaneko Y., Nojima, Y., Matozaki T.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸ポートアイランド(兵庫)
• [Presentation] Stress-evoked tyrosine phosphorylation of SIRPα mediates an antidepres sant effect (2010)
  • Author(s): Matozaki, T., et al.
  • Organizer: FASEB Summer Research Conferences "Protein Phosphatases"
  • Place of Presentation: Steamboat, Colorado, USA
• [Presentation] Expression of PTPRO in the interneurons of adult mouse olfactory bulb (2010)
  • Author(s): Kotani, T., Matozaki, T., et al.
  • Organizer: FASEB Summer Research Conferences "Protein Phosphatases"
  • Place of Presentation: Steamboat, Colorado, USA
• [Presentation] Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrin (2010)
  • Author(s): Mori, M., Matozaki, T., et al.
  • Organizer: FASEB Summer Research Conferences "Protein Phosphatases"
  • Place of Presentation: Steamboat, Colorado, USA
• [Presentation] Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues. (2010)
  • Author(s): Saito, Y., Matozaki, T., et al.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] チロシンリン酸化シグナルによる脳のストレス応答制御 (2010)
  • Author(s): 大西浩史、的崎尚, 他
  • Organizer: Neuro 2010(第33回日本神経科学大会、第53回日本神経化学会大会、第20回日本神経回路学会大会、合同大会)
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Stress-evoked tyrosine phosphorylation of SIRPα mediates an antidepressant effect (2010)
  • Author(s): Ohnishi, H., Matozaki, T., et al.
  • Organizer: 40th Annual Meeting of Society for Neuroscience, Neuroscience 2010
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] CD47-SIRPα系による免疫機能制御 (2009)
  • Author(s): 齋藤泰之、岩村紘子、金澤義丈、橋本美穂、村田陽二、大西浩史、金子和光、野島美久、的崎尚
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都
• [Presentation] Roles of the CD47-SIRPa signaling in homeostasis of lymphoid tissue dendritic cells and development of autoimmune diseases. (2009)
  • Author(s): Matozaki T., Saito Y., Iwamura H., Kanazawa Y., Sato-Hashimoto M., Murata Y., Ohnishi H., Kaneko Y., Nojima Y.
  • Organizer: G-COE Program International Symposium
  • Place of Presentation: 秋田大学(秋田)
• [Presentation] Essenntial roles of the CD47-SIRPα signaling for homeostasis of lymphoid tissue dendritic cells (2009)
  • Author(s): Saito, Y., et al.
  • Organizer: Immune Regulation : Present and Future
  • Place of Presentation: 大阪国際会議場
• [Presentation] Promotion by VE-PTP of lamellipodium formation in cooperation with Ras and integrin (2009)
  • Author(s): 森宗昌、的崎尚, 他
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] SAP-1 is an intestinal microvillus-specific protein tyrosine phosphatase that protects against colitis in cooperation with IL-10 (2009)
  • Author(s): 村田陽二、的崎尚, 他
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Roles of the CD47-SIRPα signaling in homeostasis of lymphoid tissue dendritic cells and development of autoimmune diseases (2009)
  • Author(s): Matozaki, T., et al.
  • Organizer: G-COE Program International Symposium
  • Place of Presentation: 秋田大学
• [Presentation] Tyrosine phosphorylation of SAP-1, a receptor-type protein tyrosine phosphatase, and ist association with Grb2 (2009)
  • Author(s): 村田陽二、的崎尚, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パイフィコ横浜
• [Presentation] Promotion by VE-PTP of lamellipodium formation in cooperation with Ras and integrin (2009)
  • Author(s): 森宗昌、的崎尚, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 腸微絨毛特異的な発現を示す受容体型チロシンホスファターゼSAP-1とIL-10による炎症性腸疾患の制御 (2009)
  • Author(s): 小谷武徳、的崎尚, 他
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] VE-PTPによるRas,インテグリン依存的なラメリポディア形成の促進 (2009)
  • Author(s): 森宗昌、的崎尚, 他
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] CD47-SIRPαシグナル系によるリンパ組織内樹状細胞の恒常性の制御 (2009)
  • Author(s): 齊藤泰之、的崎尚, 他
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都国際会議場
• [Presentation] レセプター型チロシンボスファターゼの発現、機能と病態への関与 (2008)
  • Author(s): 的崎 尚
  • Organizer: G-COE合同シンポジウム
  • Place of Presentation: 秋田市明徳館ビル
  • Year and Date: 2008-10-18
• [Presentation] 腸管におけるSHPS-1発現と腸管免疫制御 (2008)
  • Author(s): 金澤義丈、齋藤泰之、ヤナ・スプリアトナ、村田陽二、岡澤秀樹、大西浩史、下瀬川透、的崎尚
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都国際会館(京都)
• [Presentation] SHPS-1は樹状細胞の恒常性に重要である (2008)
  • Author(s): 齋藤泰之、金子和光、岩村紘子、金澤義丈、村田陽二、大西浩史、野島美久、的崎尚
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都国際会館(京都)
• [Presentation] Expression of SHPS-1 in pancreatic β-cells and its role in promotion of insulin secretion and protection against diabetes. (2008)
  • Author(s): Kobayashi M., Ohnishi H., Okazawa H.Murata Y., Hayashi Y., Kobayashi H.Kitamura T., Matozaki T.
  • Organizer: 第8回国際プロテインホスファターゼカンファレンス
  • Place of Presentation: 前橋テルサ(群馬)
• [Presentation] Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system. (2008)
  • Author(s): Kusakari S., Ohnishi H., Okazawa H., Murata T., Murata Y., Matozaki T.
  • Organizer: 第8回国際プロテインホスファターゼカンファレンス
  • Place of Presentation: 前橋テルサ(群馬)
• [Presentation] チロシンポスファターゼによるがん、炎症性腸炎の制御 (2008)
  • Author(s): 的崎尚、岡澤秀樹、村田陽二、大西浩史
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知)
• [Presentation] Essential roles of SHPS-1 in homeo-stasis of dendritic cells. (2008)
  • Author(s): 齋藤泰之、金子和光、岩村紘子、金澤義丈、村田陽二、大西浩史、野島美久、的崎尚
  • Organizer: 第10回国際樹状細胞シンポジウム
  • Place of Presentation: 神戸国際会議場(兵庫)
• [Presentation] CD47とSHPS-1のトランスエンドサイトーシスとCD47-SHPS-1系の制御における役割 (2008)
  • Author(s): 大西浩史、草苅伸也、村田考啓、村田陽二、岡澤秀樹、的崎尚
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: パシフィコ横浜(神奈川)
• [Presentation] 受容体型膜蛋白質SHPS-1のインスリン分泌制御における機能解析 (2008)
  • Author(s): 小林雅樹、大西浩史、岡澤秀樹、村田陽二、林由里子、北村忠弘、的崎尚
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] 受容体型膜蛋白質SHPS-1のインスリン分泌制御における機能解析 (2008)
  • Author(s): 小林雅樹、的崎 尚 他
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] CD47とSHPS-1のトランスエンドサイトーシスとCD47-SHPS-1系の制御における役割 (2008)
  • Author(s): 大西浩史、的崎 尚 他
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] SAP-1 is a microvillus-specific protein tyrosine phosphatase that regulates intestinal tumorigenesis (2008)
  • Author(s): Sadakata, H. et al.
  • Organizer: FASEB Summer Research Confetences
  • Place of Presentation: Snowmass, Colorado、米国
• [Presentation] Regulationof CD47-SHPS-1 systembytrans-endocytosis (2008)
  • Author(s): 草苅伸也、的崎 尚 他
  • Organizer: 第9回文部科学省特定領域研究「がん」5領域若手研究穿者ワークショップ
  • Place of Presentation: アートランドホテル蓼科
• [Presentation] Essential roles of SHPS-1 in homeostasis of dendritic cells (2008)
  • Author(s): Saito, Y. et al.
  • Organizer: 第10回国際樹状細胞シンポジウみ
  • Place of Presentation: 神戸国際会議場
• [Presentation] SAP-1 is a microvillus-specific protein tyrosine phosphatase that regulates intestinal tumorigenesis and inflammation (2008)
  • Author(s): Matozaki, T.
  • Organizer: 第8回国際プロテインボスファターゼカンファレンス
  • Place of Presentation: 前橋テルサ
• [Presentation] Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system (2008)
  • Author(s): Kusakari, S. et al
  • Organizer: 第8回国際プロテインボスファターゼカンファレンス
  • Place of Presentation: 前橋テルサ
• [Presentation] Expression of SHPS-1 in pancreatic β-cells and its role in promotion of insulin secretion and protection against diabetes (2008)
  • Author(s): Kobayashi, M. et al.
  • Organizer: 第8回国際プロテインボスファターゼカンファレンス
  • Place of Presentation: 前橋テルサ
• [Presentation] Defective development of dendritic cells in SHPS-1 mutant mice (2008)
  • Author(s): Saito, Y. et al.
  • Organizer: 第8回国際プロテインボスファターゼカンファレンス
  • Place of Presentation: 前橋テルサ
• [Presentation] チロジンボスファターゼによるがん、炎症性腸炎の制御 (2008)
  • Author(s): 的崎 尚
  • Organizer: 第67回目本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] SHPS-1は樹状細胞の恒常性に重要である (2008)
  • Author(s): 斉藤泰之、的崎尚他
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都国際会議場
• [Presentation] 腸管におけるSHPS-1発現と腸管免疫制御 (2008)
  • Author(s): 金澤義丈、的崎尚他
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都国際会議場
• [Presentation] クラス3受容体型チロシンボスファターゼの機能と病態への関与 (2008)
  • Author(s): YanaSupriatona、的崎尚他
  • Organizer: 第31回日本分子生物学会年会 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
• [Presentation] 腸微絨毛特異的発現を示すチロシンボスファターゼSAP-1による腸管腫瘍形成の制御 (2008)
  • Author(s): 定方久延、的崎尚他
  • Organizer: 第31回日本分子生物学会年会 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
• [Presentation] 受容体型チロシンポスファターゼSAP-1のチロシンリン酸化とその生理的意義 (2008)
  • Author(s): 村田陽二、的崎尚他
  • Organizer: 第31回日本分子生物学会年会 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
• [Book] シグナル伝達研究2008-'09 Vol.26No.15 (2008)
  • Author(s): 的崎尚、岡田雅人、他
  • Total Pages: 248
  • Publisher: 羊土社
• [Book] シグナル伝達研究(2008-'09 Vo1.26 No.15)
  • Author(s): 的崎尚、岡田雅人、他
  • Total Pages: 248
  • Publisher: 羊土社
• [Remarks] ホームページ等
  • URL: http://www.imcr.gunma-u.ac.jp/lab/biosig/
• [Remarks] ホームページ等
  • URL: http://www.med.kobe-u.ac.jp/tougou/signall/index.html
• [Remarks]
  • URL: http://www.imcr.gunma-u.ac.jp/lab/biosig/
• [Remarks]
  • URL: http://imcr.showa.gunma-u.ac.jp/lab/brc/index.html
• [Remarks]
  • URL: http://www.imcr.gunma-u.ac.jp/lab/biosig/
• [Patent(Industrial Property Rights)] マクロファージ活性化剤並びにその製造方法及びスクリーニング方法 (2008)
  • Inventor(s): 的崎尚、大西浩史
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Acquisition Date: 2008-12-05
• [Patent(Industrial Property Rights)] Pharmaceutical Composition and Method for Activating Macrophage Using theSame(医薬組成物及びそれを用いたマクロファージの活性化方法) (2008)
  • Inventor(s): 的崎尚、大西浩史
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Acquisition Date: 2008-11-11
  • Overseas