Structure and Function of MBP-ligand oligosaccharides isolated from SW1116 cells
Project/Area Number |
20370052
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Functional biochemistry
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Research Institution | Ritsumeikan University |
Principal Investigator |
KAWASAKI Toshisuke Ritsumeikan University, 総合理工学研究機構, 教授 (50025706)
|
Co-Investigator(Kenkyū-buntansha) |
MA BRUCE 立命館大学, 立命館グローバル・イノベーション研究機構, 准教授 (00378788)
KAWASAKI Nobuko 立命館大学, 総合理工学研究機構, 教授 (70077676)
|
Co-Investigator(Renkei-kenkyūsha) |
ISHIGURO Masaji 新潟薬科大学, 応用生物科学部, 教授 (10280687)
ISHIDA Hideharu 岐阜大学, 応用生物科学部, 教授 (20203002)
KATO Koichi 名古屋市立大学, 薬学研究科, 教授 (20211849)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
|
Keywords | 癌 / 糖鎖 / 先天性免疫 / 動物レクチン / 臨床試料 / がん / 腫瘍マーカー / マンナン結合タンパク質 / ルイスaエピトープ / ルイスxエピトープ / コンピュータモデリング / 糖鎖パターン認識 / 免疫学 / 生体分子 / 生理活性 |
Research Abstract |
Based on the biochemical data obtained, we proposed a computer modeling of the molecular complex of the serum mannan-binding protein and its high affinity ligand oligosaccharides on SW1116 cells. Immunohistochemical analysis indicated that the MBP-ligand oligosaccharides are novel tumor marker candidates.
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Report
(4 results)
Research Products
(81 results)
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[Journal Article] Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) recognizes a novel ligand, Mac-2-binding protein, characteristically expressed on human colorectal carcinomas2011
Author(s)
Nonaka M, Ma BY, Imaeda H, Kawabe K, Kawasaki N, Hodohara K, Kawasaki N, Andoh A, Fujiyama Y, Kawasaki T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Highly Fucosylated N-Glycan Ligands for Mannan-binding Protein Expressed Specifically on CD26 (DPPVI) Isolated from a Human Colorectal Carcinoma Cell Line, SW11162009
Author(s)
Kawasaki N, Lin CW, Inoue R, Khoo KH, Kawasaki N, Ma BY, Oka S, Ishiguro M, Sawada T, Ishida H, Hashimoto T, Kawasaki T
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Journal Title
Glycobiology 19
Pages: 437-450
Related Report
Peer Reviewed
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[Journal Article] Highly Fucosylated N-Glycan Ligands for Mannan-binding Protein Expressed Specifically on CD26 (DPPVI) Isolated from a Human Colorectal Carcinoma Cell Line, SW11162009
Author(s)
Kawasaki N, Lin CW, Inoue R, Khoo KH, Kawasaki N, Ma BY, Oka S, Ishiguro M, Sawada T, Ishida H, Hashimoto T, Kawasaki T.
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Journal Title
Glycobiology 19
Pages: 437-450
Related Report
Peer Reviewed
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