| Project/Area Number |
20370055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
SORIMACHI Hiroyuki Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員 (10211327)
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| Co-Investigator(Kenkyū-buntansha) |
小野 弥子 (財)東京都医学研究機構, 東京都臨床医学総合研究所, 主任研究員 (20392376)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Yasuko 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主席研究員 (20392376)
HATA Shoji 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主席研究員 (10392375)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 細胞内タンパク質分解 / カルパイン / カルシウム / 内膜輸送系 / 胃腸 / 酵素 / 蛋白質 / プロテオリシス / メンブレン・トラフィック / 骨格筋 |
|---|
| Research Abstract |
Calpains, which are encoded by 15 genes in humans, constitute a family of intracellular Ca^<2+>-dependent proteases. They function to protect living organisms, and, therefore, defects in calpain functions result in lethality or diseases like muscular dystrophy. In this study, we focused on calpain-7/PalBH, which is conserved from human to yeast but has not been studied well so far. As a result, it was suggested that calpain-7 also plays essential roles for mammalian life like calpain-2 and-3.
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