転写・RNAプロセシング・輸送の機能的連携と統合による遺伝子発現調節機構の解明
Project/Area Number |
20370070
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Molecular biology
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Research Institution | Kumamoto University |
Principal Investigator |
TANI Tokio Kumamoto University, 大学院・自然科学研究科, 教授 (80197516)
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Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
Keywords | スプライシング / 転写 / mRNA輸送 / 分裂酵母 / 遺伝子発現制御 / RNAプロセシング / 核 / mRNA3'末形成 / mRNA 3'末形成 / 翻訳 / 核膜孔複合体 |
Research Abstract |
Recent emerging evidence suggested that a functional linkage among transcription, pre-mRNA splicing and nuclear mRNA export, which had been analyzed independently, exists in a living cell. However, the molecular mechanism of the linkage still remains unclear. In this study, we analyzed the genes responsible for the fission yeast mutations that cause defective pre-mRNA splicing and nuclear mRNA export, and elucidated a part of the molecular mechanism of coordinated regulation of gene expression in eukaryotic cells.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] S1-1 nuclear domains : characterization and dynamics as a function of transcriptional activity.2008
Author(s)
Akira Inoue, Katsuji Tsugawa, Kazuaki Tokunaga, KeniChiP. Takahashi, Shigehiko Uni, Masatsugu Kimura, Koji Nishio, Naoki Yamamoto, Ken-ichi Honda, Takanori Watanabe, Hideo Yamane, Tokio Tani.
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Journal Title
Biology of the Cell 100
Pages: 523-535
Related Report
Peer Reviewed
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