Budget Amount *help |
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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Research Abstract |
To elucidate the mechanism of activation of extracytoplasmic stress response by abnormal membrane proteins("membrane stress response),(1) we isolated and analyzed suppressor mutations against a class of the secY mutations that elicit membrane stress response, and(2) from the analysis of RseP PDZ domain mutants, we suggest a new Sigma E activation memsahib via ligand binding to the PDZ domains.
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