Studies on the structure and function of the nucleus in senescent cells
| Project/Area Number |
20370079
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kyoto University |
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Principal Investigator |
ISHIKAWA Fuyuki Kyoto University, 大学院・生命科学研究科, 教授 (30184493)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | テロメア / 細胞老化 / NF-kappaB / ヘテロクロマチン / ヒストンH1 / HMGA / lamin / NFkappaB |
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| Research Abstract |
We have previously reported that histone H1 disappears and HMGA proteins are increased in cellular senescent cells. In this study, we further examined the structure and function of the nucleus in senescent cells. We found that 1) histone H1 is likely degraded via the ubiqutin-proteasome pathway, 2) the NF-kB pathway is involved in inducing the characteristic gene expression profiles in senescent cells, and 3) the nuclear membrane is structurally and biochemically dysfunctional. These results will provide a means to control the senescence phenotypes.
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Report
(3 results)
Research Products
(63 results)
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[Journal Article] RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway2009
Author(s)
Miyake, Y., Nakamura, M., Nabetani, A., Shimamura, S., Tamura, M., Yonehara, S., Saito, M., Ishikawa, F.
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Journal Title
Mol Cell 36
Pages: 193-206
Related Report
Peer Reviewed
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[Journal Article] A crucial role for adipose tissue p53 in the regulation of insulin resistance2009
Author(s)
Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., Ishikawa, F., Komurao, I.
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Journal Title
Nat Med 15
Pages: 1082-1087
Related Report
Peer Reviewed
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[Journal Article] Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes2008
Author(s)
Satoh, D., Sato, D., Tsuyama, T., Saito, M., Ohkura, H., Rolls, M.M., Ishikawa, F., Uemura, T.
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Journal Title
Nat Cell Biol 10
Pages: 1164-1171
Related Report
Peer Reviewed
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[Presentation] Low-Dose Stress Responses2009
Author(s)
Fuyuki Ishikawa
Organizer
The 5th International Fission Yeast meeting 'Pombe 2009
Place of Presentation
National Olympics Memorial Youth Center, Tokyo
Year and Date
2009-10-29
Related Report
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[Presentation] Low-Dose Stress Responses2009
Author(s)
石川冬木
Organizer
The 5th International Fission Yeast meeting 'Pombe 2009'
Place of Presentation
National Olympics Memorial Youth Center, Tokyo
Year and Date
2009-10-29
Related Report
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[Presentation] Ctc1-Stn1-Ten1 complex2009
Author(s)
Fuyuki Ishikawa
Organizer
CSHL meeting 'Telomere and Telomerase'
Place of Presentation
Cold Spring Harbor Laboratory, NY, U.S.A
Year and Date
2009-04-29
Related Report
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[Presentation] 低容量ストレス反応.2008
Author(s)
石川冬木
Organizer
日本生化学会東北支部第74回例会
Place of Presentation
アイーナいわて県民交流センター
Year and Date
2008-05-17
Related Report
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