Functional analysis of the kinase complex that regulates the connection between the centrosome cycle and M phase.

• Project/Area Number: 20370081
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: NOJIMA Hiroshi Osaka University, 微生物病研究所, 教授 (30156195)
• Co-Investigator(Kenkyū-buntansha): YABUTA Norikazu 大阪大学, 微生物病研究所, 助教 (10343245) ; OKUZAKI Daisuke 大阪大学, 微生物病研究所, 助教 (00346131) ; NAITO Yoko 大阪大学, 微生物病研究所, 特任研究員 (10553026) ; KASAMA Takashi 大阪大学, 微生物病研究所, 特任研究員 (20456932)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000); Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 細胞周期 / 中心体 / 紡錘体形成チェックポイント / LATS2 / GAK / Cyclin G / PP2A B'γ / リン酸化 / PP2A B'alpha / PP2AB'alha

Research Abstract

The roles of the Lats1/2 and KBG complexes that connect centrosome cycle and M phase are analyzed. We found that Lats1/2 kinase links the signal emitted from centrosomal Aurora A to Aurora B kinases and that the he signal emitted from centrosomal Chkl kinase to CDC25, an M phase phosphatese, thereby connecting the centrosomal signal to the M phase regulatory machinery. Moreover, we showed and pointed out that the centrosomal GAK regulates PP2A B'γ that may control the phosphorylation states of certain M phase targets.

Research Products

• [Journal Article] A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage. (2011)
  • Author(s): Okada N, Yabuta N, Suzuki H, Aylon Y, Oren M, Nojima H.
  • Journal Title: J.Cell Sci. 124(Pt1) Pages: 57-67
  • Peer Reviewed
• [Journal Article] a novel hollow fiber array for focused microarray analysis. (2010)
  • Author(s): Okuzaki D, Fukushima T, Tougan T, Ishii T., Kobayashi S, Yoshizaki K, Akita T, Nojima H. Genopal TM
  • Journal Title: DNA Res. 17(6) Pages: 369-79
  • Peer Reviewed
• [Journal Article] The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe. (2010)
  • Author(s): Tougan T, Kasama T, Ohtaka A, Okuzaki D, Saito TT, Russell P, Nojima H.
  • Journal Title: Cell Cycle. 9(23) Pages: 4688-4702
  • Peer Reviewed
• [Journal Article] Nucleoredoxin Sustains Wnt/β-Catenin Signaling by Retaining a Pool of Inactive Dishevelled Protein. (2010)
  • Author(s): Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H, Yoshida N, Miki H.
  • Journal Title: Curr.Biol. 20(21) Pages: 1945-1952
  • Peer Reviewed
• [Journal Article] The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1. (2010)
  • Author(s): Aylon Y, Ofir-Rosenfeld, Y., Yabuta N, Lap, E. Nojima H, Lu, X., Oren M.
  • Journal Title: Genes Dev. 24(21) Pages: 2420-2429
  • Peer Reviewed
• [Journal Article] Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe. (2010)
  • Author(s): Okuzaki D, Kasama T, Hirata A, Ohtaka A, Kakegawa R, Nojima H.
  • Journal Title: Cell Cycle. 9(18) Pages: 3751-3760
  • Peer Reviewed
• [Journal Article] Mug28, a Meiosis-specific Protein of Schizosaccharomyces pombe, Regulates Spore Wall Formation. (2010)
  • Author(s): Shigehisa A, Okuzaki D, Kasama T, Tohda H, Hirata A, Nojima H.
  • Journal Title: Mol Biol Cell. 21(12) Pages: 1955-1967
  • Peer Reviewed
• [Journal Article] Mug28, a Meiosis-specific Protein of Schizosaccharomyces pombe, Regulates Spore Wall Formation. (2010)
  • Author(s): Shijehisa A, Okuzaki D, Kasama T, Tohda H, Hirata A, Nojima H.
  • Journal Title: Mol Biol Cell. Volume: 21(12) Pages: 1955-1967
  • Peer Reviewed
• [Journal Article] Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe. (2010)
  • Author(s): Okuzaki D, Kasama T, Hirata A, Ohtaka A, Kakegawa R, Nojima H.
  • Journal Title: Cell Cycle Volume: 9(18) Pages: 3751-3760
  • Peer Reviewed
• [Journal Article] Nucleoredoxin Sustains Wnt/β-Catenin Signaling by Retaining a Pool of Inactive Dishevelled Protein. (2010)
  • Author(s): Funato Y, Terabayashi T, Sakamoto P, Okuzaki D, Ichise H, Nojima H, Yoshida N, Miki H.
  • Journal Title: Curr.Biol Volume: 20(21) Pages: 1945-1952
  • Peer Reviewed
• [Journal Article] The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1. (2010)
  • Author(s): Aylon Y, Ofir-Rosenfeld, Y., Yabuta N, Lap, E.Nojima H, Lu, X.and Oren M.
  • Journal Title: Genes Dev. Volume: 24(21) Pages: 2420-2429
  • Peer Reviewed
• [Journal Article] Gencipal TM : a novel hollow fiber array for focused microarray analysis. (2010)
  • Author(s): Okuzaki D, Fukushima T, Tougan T, Ishii T., Kobayashi S, Yoshizaki K, Akita T, Nojima H.
  • Journal Title: DNA Res. Volume: 17(6) Pages: 369-379
  • Peer Reviewed
• [Journal Article] The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe. (2010)
  • Author(s): Tougan T, Kasama T, Ohtaka A, Okuzaki D, Saito TT, Russell P, Nojima H.
  • Journal Title: Cell Cycle. Volume: 9(23) Pages: 4688-4702
  • Peer Reviewed
• [Journal Article] Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation. (2009)
  • Author(s): Aylon Y, Yabuta N, Besserglick H, Buganim Y, Rotter V, Nojima H, Oren M.
  • Journal Title: Oncogene. 28(50) Pages: 4469-4479
  • Peer Reviewed
• [Journal Article] GAK, a regulator of clathrin-mediated membrane traffic, also controls centrosome integrity and chromosome congression. (2009)
  • Author(s): Shimizu H, Nagamori I, Yabuta N, Nojima H
  • Journal Title: J Cell Sci. 122(Pt17) Pages: 3145-3152
  • Peer Reviewed
• [Journal Article] GAK, a regulator of clathrin-mediated membrane trafficking, localizes not only in the cytoplasm but also in the nucleus. (2009)
  • Author(s): Sato, J., Shimizu, H., Kasama, T., Yabuta, N. Nojima, H.
  • Journal Title: Genes Cells 14 Pages: 627-641
  • Peer Reviewed
• [Journal Article] The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. (2009)
  • Author(s): Nishioka, N., Inoue, K., Adachi, K., Kiyonari, H., Ota, M., Ralston, A., Yabuta, N., Hirahara, S., Stephenson., R.O., Ogonuki, N., Makita, R., Kurihara, H., Morin-Kensicki, E.M., Nojima, H., Rossant, J., Nakao, K., Niwa, H. Sasaki, H.
  • Journal Title: Dev Cell. 16(3) Pages: 398-410
  • Peer Reviewed
• [Journal Article] Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation. (2009)
  • Author(s): Aylon Y, Yabuta N, Besserglick H, Buganim Y, Rotter V, Nojima H, Oren M.
  • Journal Title: Oncogene. Volume: 50 Pages: 4469-79
  • Peer Reviewed
• [Journal Article] The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass (2009)
  • Author(s): Nishioka, N., et al.
  • Journal Title: Developmental Cell (印刷中)
  • Peer Reviewed
• [Journal Article] Lats2 is a negative regulator of myocyte size in the heart. (2008)
  • Author(s): Matsui Y, Nakano N, Shao D, Gao S, Luo W, Hong C, Zhai P, Holle E, Yu X, Yabuta N, Tao W, Wagner T, Nojima H, Sadoshima J.
  • Journal Title: Circ Res. 103(11) Pages: 1309-1318
  • Peer Reviewed
• [Journal Article] Chum-RNA allows preparation of a high-quality cDNA library from a single-cell quantity of mRNA without PCR amplification. (2008)
  • Author(s): Tougan T, Okuzaki D, Nojima H.
  • Journal Title: Nuc.Acids Res. 36(15)
  • Peer Reviewed
• [Journal Article] Mug27 is a meiosis-specific protein kinase that functions in fission yeast meiosis II and sporulation. (2008)
  • Author(s): Ohtaka A, Okuzaki D, Nojima H.
  • Journal Title: J.Cell Sci. 121(9) Pages: 1547-1558
  • Peer Reviewed
• [Journal Article] Lats2 is a negative regulator of myocyte size in the heart (2008)
  • Author(s): Matsui, Y., et al.
  • Journal Title: Circulation Research 103 Pages: 1309-1318
  • Peer Reviewed
• [Journal Article] Mug27 is a meiosis-specific protein kinase that functions in fission yeast meiosis II and sporulation (2008)
  • Author(s): A.Ohtaka, et al.
  • Journal Title: Journal of Cell Science 121 Pages: 1547-58
  • Peer Reviewed
• [Presentation] Lats2 links Chk1-mediated DNA damage signal to the P-body formation through phosphorylation of 14-3-3 (2011)
  • Author(s): Suzuki H, Okada N, Mukai S, Yabuta N, Nojima H
  • Organizer: International Symposium on the Physicochemical Field for Genetic Activities
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2011-02-24
• [Presentation] Lats1ΔN/ΔN cells that express N-terminally truncated Lats1 kinase causes chromosomal inst ability (2011)
  • Author(s): Mukai S, Yabuta N, Suzuki H, Okada N, DMiura D, Okuzaki D, Nojima H
  • Organizer: Pysicochemical Field for Genetic Activities
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2011-01-24
• [Presentation] Lats2 links Chk1-mediated DNA damage signal to the P-body formationthrough phosphorylation of 14-3-3 (2010)
  • Author(s): Suzuki H, Okada N, Mukai S, Yabuta N, Nojima H
  • Organizer: The 50th American Society for Cell biology annual meeting
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, USA
  • Year and Date: 2010-12-12
• [Presentation] The N-terminally truncated Lats1 kinase causes chromosomal instability and tumorigenesis in nude mice. (2010)
  • Author(s): Mukai S, Yabuta N, Suzuki H, Okada N, Miura D, Nojima H.
  • Organizer: 2010 The American Society for Cell Biology Annual Meeting
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, USA
  • Year and Date: 2010-12-12
• [Presentation] Cyclin G-associated kinase regulates protein phosphatase 2A by phosphorylation of its B'gamma subunit (2010)
  • Author(s): 内藤陽子, 清水寛之, 笠間隆志, 佐藤淳, 田原洋栄, 勝間亜沙子, 薮田紀一, 野島博
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-10
• [Presentation] The Aurora-A-Lats1/2-Aurora-B axis is a novel pathway that regulates precise mitotic progression (Aurora-A-Lats1/2-Aurora-B経路は厳密なM期進行を制御する新たな経路である). (2010)
  • Author(s): 藪田紀一、向井智美、岡田宣宏、鈴木宏和、野島博
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] A novel Diagnostic markers for Takayasu Arteritis obtained by GenopalTM focused microarray based on Spearman rank correlation (2010)
  • Author(s): 奥崎大介、野島博
  • Organizer: 第33回日本分子生物学会大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] DNA損傷に応答してLats2により制御されるマイクロRNA(miRNA)の単離と機能解析 (2010)
  • Author(s): 鈴木宏和、岡田宣宏、向井智美、薮田紀一、野島博
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド(口頭発表)
  • Year and Date: 2010-12-09
• [Presentation] N末欠損型Lats1ノックアウトマウス由来の繊維芽細胞は細胞分裂が異常でヌードマウスに腫瘍を形成する (2010)
  • Author(s): 向井智美、薮田紀一、鈴木宏和、岡田宣宏、三浦大作、野島博
  • Organizer: 第33回日本分子生物学会年会 第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] DNA損傷に応答してLats2により制御されるマイクロRNA(miRNA)の単離と機能解析 (2010)
  • Author(s): 鈴木宏和、岡田宣宏、向井智美、薮田紀一、野島博
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] Lats1DN/DN MEFs expressing the N-terminal truncated Lats1 protein showed mitotic defects and formed tumors in nude mice. (2010)
  • Author(s): Nojima H, Mukai S, Suzuki H, Okada N, Miura D, Okuzaki D, Yabuta N
  • Organizer: The second workshop on the HIPPO tumor suppressor pathway
  • Place of Presentation: Rome, Italy
  • Year and Date: 2010-11-04
• [Presentation] Lats1DN/DN MEFs expressing the N-terminal truncated Lats1 protein showed mitotic defects and formed tumors in nude mice. (2010)
  • Author(s): Nojima H, Mukai S, Suzuki H, Okada N, Miura D, Okuzaki D, Yabuta N
  • Organizer: The second workshop on the HIPPO tumor suppressor pathway
  • Place of Presentation: Rome, Italy(招待講演)
  • Year and Date: 2010-11-04
• [Presentation] An Aurora-A-Lats2-Aurora-B pathway is required for accurate mitotic progression. (2010)
  • Author(s): Yabuta N, Mukai S, Okada N, Suzuki H, Aylon Y, Nojima H.
  • Organizer: The second workshop on the HIPPO tumor suppressor pathway
  • Place of Presentation: Rome, Italy(招待講演)
  • Year and Date: 2010-11-04
• [Presentation] The tumor suppressor Lats2 is a signaling nexus of Aurora-A to Aurora-B during mitosis(癌抑制因子Lats2はAurora-AとAurora-Bを繋ぐ新たなシグナル経路を形成する) (2010)
  • Author(s): 薮田紀一、岡田宣宏、向井智美、鈴木宏和、野島博
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] GAKはプロテインホスファターゼ2Aの調節サブユニットB'γをリン酸化することにより脱リン酸化を制御する (2010)
  • Author(s): 内藤陽子、勝間亜沙子、薮田紀一、野島博
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] Lats2はChk1を介したDNA損傷シグナルを14-3-3のリン酸化を経由してP-body形成に連繋する (2010)
  • Author(s): 鈴木宏和、岡田宣宏、向井智美、薮田紀一、野島博
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] Lats1/WartsキナーゼのN末端領域は染色体安定性と腫瘍抑制に必要である (2010)
  • Author(s): 向井智美、薮田紀一、鈴木宏和、岡田宣宏、野島博
  • Organizer: 第69回日本癌学会 学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] A novel Diagnostic markers for Takayasu Arteritis obtained by Genopal focused microarray based on Spearman rank correlation (2010)
  • Author(s): Okuzaki D, Fukushima T, Tougan, T, Ishii T, Kobayashi S, Yoshizaki K, Akita T, Nojima H.
  • Organizer: The 10th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji Hyogo
  • Year and Date: 2010-09-08
• [Presentation] GAKはプロテインホスファターゼPP2Aの制御サブユニットB'γをリン酸化することにより脱リン酸活性を制御する (2010)
  • Author(s): 内藤陽子、清水寛之、笠間隆志、佐藤淳、田原洋栄、勝間亜沙子、薮田紀一、野島博
  • Organizer: 第57回日本生化学会近畿支部例会
  • Place of Presentation: 奈良
  • Year and Date: 2010-05-22
• [Presentation] キナーゼ領域を欠損させたGAK変異マウスの解析 (2010)
  • Author(s): 勝間亜沙子、内藤陽子、田原洋栄, 清水寛之、薮田紀一、野島博
  • Organizer: 第57回日本生化学会近畿支部例会
  • Place of Presentation: 奈良先端科学技術大学院大学
  • Year and Date: 2010-05-22
• [Presentation] GAKはB'gammaサブユニットをリン酸化することにより、タンパク質脱リン酸化酵素PP2Aの機能を制御する (2010)
  • Author(s): 内藤陽子、清水寛之、笠間隆志、佐藤淳、田原洋栄、薮田紀一、野島博
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-05-19
• [Presentation] ゲフィチニブの新規標的因子GAKのキナーゼ領域ノックアウトマウスは肺機能不全により新生児致死に至る (2010)
  • Author(s): 勝間亜沙子、伊藤彰彦、内藤陽子、薮田紀一、野島博
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Knockout mice expressing the kinase-dead form of GAK, a novel gefitinib target, suffer neonatal death due to lung dysfunction (2010)
  • Author(s): 勝間亜沙子、内藤陽子、田原洋栄, 伊藤彰彦、薮田紀一、野島博
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 血管炎患者における末梢血単核細胞由来の遺伝子マーカー単離とRNA診断法の開発 (2008)
  • Author(s): 奥崎大介
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 兵庫県神戸市 神戸ポートピアランド
  • Year and Date: 2008-12-12
• [Presentation] 分裂酵母の減数分裂においてMek1が仲介するキナーゼカスケードの機能解析 (2008)
  • Author(s): 笠間隆志
  • Organizer: 第31回日本分子生物学会年会・第81日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] DNA傷害における Cyclin G2の機能 (2008)
  • Author(s): 坂田宗紀
  • Organizer: 第31回日本分子生物学会年会・第81日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] AK(cyclin G associated kinase)の核内における機能の解析 (2008)
  • Author(s): 田原洋栄
  • Organizer: 第31回日本分子生物学会年会・第81日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Chum-RNA増幅法はPCR増幅無しでヒト1個細胞相当のmRNAから高品質cDNAライブラリー作製を可能にする (2008)
  • Author(s): 東岸任弘
  • Organizer: 第31回日本分子生物学会年会・第81日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Lats2はM期において Aurora-A キナーゼによってリン酸化されて多様な局在を示す (2008)
  • Author(s): 薮田紀一
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] 分裂酵母の減数分裂特異的リン酸化酵素:Mug27/Slk1の機能解析 (2008)
  • Author(s): 大高彩美
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Lats2による DNA damage checkpoint 制御解析 (2008)
  • Author(s): 岡田宣宏
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] 分裂酵母のMug28は胞子壁成熟を制御する (2008)
  • Author(s): 重久晃
  • Organizer: 第31回日本分子生物学会年会・第81日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Lats1とLats2キナーゼは相互作用して機能を相補する (2008)
  • Author(s): 佐藤愛
  • Organizer: 第31回日本分子生物学会年会・第81日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Aurora-Aによる多様なリン酸化はLats2のM期局在を制御する (2008)
  • Author(s): 薮田紀一
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Development of an RNA diagnostic system using PBMCs of vasculitis patients (2008)
  • Author(s): 奥崎大介
  • Organizer: 第8回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 兵庫県淡路市 兵庫県立淡路夢舞台国際会議場
  • Year and Date: 2008-09-10
• [Presentation] The fission yeast Mug27/ppk35, a mammalian Lats2 homologue, is a meiosis-specific protein kinase that functions in meiosis II and sporulation (2008)
  • Author(s): 大高彩美
  • Organizer: The 2008 Yeast Genetics and Molecular Biology Meeting
  • Place of Presentation: カナダ・トロント大学
  • Year and Date: 2008-07-23
• [Presentation] Aurora-Aによるリン酸化はM期におけるLats2の多様な局在を制御する (2008)
  • Author(s): 薮田紀一
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-29
• [Presentation] GAKは核内にも局在し機能する (2008)
  • Author(s): 笠間隆志
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-29
• [Presentation] DNA damage checkpoint におけるLats2の機能解析 (2008)
  • Author(s): 岡田宣宏
  • Organizer: 第55回日本生化学会近畿支部例会
  • Place of Presentation: 大阪
  • Year and Date: 2008-05-24
• [Presentation] Clathrin 依存性エンドサイトーシスの制御因子;GAK(Cyclin G associated kinase)の核内における機能解析 (2008)
  • Author(s): 坂田宗紀
  • Organizer: 第55回日本生化学会近畿支部例会
  • Place of Presentation: 大阪
  • Year and Date: 2008-05-24
• [Presentation] Fission yeast Arp1 facilitates meiotic nuclear oscillation via Dhc1 and Mcp5 (2008)
  • Author(s): 奥崎大介
  • Organizer: Yeast2008
  • Place of Presentation: カナダ・トロント大学
• [Book] Preparation of a high-quality cDNA library from a single-cell quantity of mRNA using Chum-RNA. In cDNA Librarires (Ed. By L.Chaofu, Browse J, Wallis JG). Humana Press (2011)
  • Author(s): Nojima H, Tougan T.
  • Publisher: Springer Science
• [Book] cDNA Librarires(Preparation of a high-quality cDNA library from a single-cell quantity of mRNA using Chum-RNA) (2011)
  • Author(s): Nojima H, Tougan T.(Ed.By L.Chaofu, Browse J, Wallis JG)
  • Publisher: Humana Press (Springer Science)
• [Remarks] ホームページ
  • URL: http://www.biken.osaka-u.ac.jp/lab/molgenet/
• [Remarks]
  • URL: http://www.biken.osaka-u.ac.jp/lab/molgenet/
• [Remarks]
  • URL: http://www.biken.osaka-u.ac.jp/lab/molgenet/
• [Remarks]
  • URL: http://www.biken.osaka-u.ac.jp/lab/molgenet/
• [Patent(Industrial Property Rights)] 全身性エリテマトーデス患者血液細胞で発現亢進している遺伝子群、およびその利用 (2011)
  • Inventor(s): 野島博、恩田弘明、佐伯行彦
  • Industrial Property Rights Holder: 科学技術振興機構
  • Acquisition Date: 2011-03-12
• [Patent(Industrial Property Rights)] ヒト腫瘍関連遺伝子とタンパク質 (2010)
  • Inventor(s): 渡邉雅文、野島博、玉井克之
  • Industrial Property Rights Holder: (株)医学生物学研究所(MBL)
  • Acquisition Date: 2010-08-13
• [Patent(Industrial Property Rights)] 白血球タンパク質の回収方法および回収装置 (2009)
  • Inventor(s): 野島博、藪田紀一、奥崎大介
  • Industrial Property Rights Holder: 大阪大学
  • Filing Date: 2009-10-26
• [Patent(Industrial Property Rights)] コネキシン26阻害剤およびそれを用いた癌転移抑制剤 (2009)
  • Inventor(s): 野島博、伊藤彰彦、北泰行
  • Industrial Property Rights Holder: 科学技術振興機構
  • Acquisition Date: 2009-06-26
• [Patent(Industrial Property Rights)] 癌転移能検査方法、および癌転移抑制薬のスクリーニング方法 (2009)
  • Inventor(s): 野島博、伊藤彰彦
  • Industrial Property Rights Holder: (株)医学生物学研究所(MBL)
  • Acquisition Date: 2009-03-27
• [Patent(Industrial Property Rights)] ヒト腫瘍関連遺伝子とタンパク質 (2008)
  • Inventor(s): 野島博、伊藤彰彦
  • Industrial Property Rights Holder: 科学技術振興機構
  • Acquisition Date: 2008-02-08