| Project/Area Number |
20370083
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
MOCHIZUKI Naoki National Cardiovascular Center Research Institute, 細胞生物学部, 部長 (30311426)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUHARA Shigetomo 独立行政法人国立循環器病研究センター, 細胞生物学部, 室長 (70332880)
三浦 浩一 独立行政法人国立循環器病研究センター, 細胞生物学部, 研究員 (20360349)
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| Co-Investigator(Renkei-kenkyūsha) |
MASUDA Michitaka 独立行政法人国立循環器病研究センター, 細胞生物学部, 室長 (00190364)
KAWAHARA Atsuo 独立行政法人国立循環器病研究センター, 細胞生物学部, 室長 (10362518)
MIURA Koichi 独立行政法人国立循環器病研究センター, 細胞生物学部, 研究員 (20360349)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | シグナル伝達 / 細胞間接着 / 血管新生 / 細胞接着 / GTP結合蛋白質 / 血管内皮細胞 |
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| Research Abstract |
Angiopopoetin-1(Ang1)-Tie2 signal promotes the expression of Kruppel-like factor 2 that is known to be a transcription factor essential for vascular quiescence. In addition, Ang1/Tie2 induces Dll4 expression by inhibiting degradation of beta-catenin in a manner dependent on AKT. Dll4/Notch signal upon cell-cell contacts is believed to inhibit VEGF-VEGFR2 signal. Collectively, Ang1/Tie2 signal stabilizes endothelial cells by inhibiting VEGF-VEGFR2 signal.
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