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Molecular mechanism of adhesion and deadhesion of endothelial cells required for angiogenesis

Research Project

Project/Area Number 20370083
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

MOCHIZUKI Naoki  National Cardiovascular Center Research Institute, 細胞生物学部, 部長 (30311426)

Co-Investigator(Kenkyū-buntansha) FUKUHARA Shigetomo  独立行政法人国立循環器病研究センター, 細胞生物学部, 室長 (70332880)
三浦 浩一  独立行政法人国立循環器病研究センター, 細胞生物学部, 研究員 (20360349)
Co-Investigator(Renkei-kenkyūsha) MASUDA Michitaka  独立行政法人国立循環器病研究センター, 細胞生物学部, 室長 (00190364)
KAWAHARA Atsuo  独立行政法人国立循環器病研究センター, 細胞生物学部, 室長 (10362518)
MIURA Koichi  独立行政法人国立循環器病研究センター, 細胞生物学部, 研究員 (20360349)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywordsシグナル伝達 / 細胞間接着 / 血管新生 / 細胞接着 / GTP結合蛋白質 / 血管内皮細胞
Research Abstract

Angiopopoetin-1(Ang1)-Tie2 signal promotes the expression of Kruppel-like factor 2 that is known to be a transcription factor essential for vascular quiescence. In addition, Ang1/Tie2 induces Dll4 expression by inhibiting degradation of beta-catenin in a manner dependent on AKT. Dll4/Notch signal upon cell-cell contacts is believed to inhibit VEGF-VEGFR2 signal. Collectively, Ang1/Tie2 signal stabilizes endothelial cells by inhibiting VEGF-VEGFR2 signal.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 2008 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (4 results) Remarks (2 results)

  • [Journal Article] Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of {beta}-Catenin.2011

    • Author(s)
      Zhang J.
    • Journal Title

      J.Biol.Chem. 286

      Pages: 8055-8066

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Docking Protein Gab1 Is an Essential Component of Postnatal Angiogenesis After Ischemia via HGF/c-Met Signaling.2011

    • Author(s)
      Shioyama W.
    • Journal Title

      Circ Res. 108

      Pages: 664-675

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of {beta}-Catenin.2011

    • Author(s)
      Zhang J
    • Journal Title

      J.Biol.Chem

      Volume: 286 Pages: 8055-8066

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Docking Protein Gab1 Is an Essential Component of Postnatal Angiogenesis After Ischemia via HGF/c-Met Signaling.2011

    • Author(s)
      Shioyama W
    • Journal Title

      Circ.Res.

      Volume: 108 Pages: 664-675

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular Endothelial-Cadherin Stabilizes at Cell-Cell Junctions by Anchoring to Circumferential Actin Bundles through a- and b-Catenins in Cyclic AMP-Epac-Rap1 Signal-activated Endothelial Cells.2010

    • Author(s)
      Noda K, Zhang J, Fukuhara S, Kunimoto S, Yoshimura M, Mochizuki N.
    • Journal Title

      Mol.Biol.Cell 21

      Pages: 584-596

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.2010

    • Author(s)
      Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N.
    • Journal Title

      Cancer Res. 70

      Pages: 1215-1224

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular Endothelial-Cadherin Stabilizes at Cell-Cell Junctions by Anchoring to Circumferential Actin Bundles through α- and β-Catenins in Cyclic AMP-Epac-Rapl Signal-activated Endothelial Cells.2010

    • Author(s)
      Noda K, Zhang J, Fukuhara S, Kunimoto S, Yoshimura M, Mochizuki N.
    • Journal Title

      Mol.Biol.Cell 21

      Pages: 584-596

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PSFl, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.2010

    • Author(s)
      Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N.
    • Journal Title

      Cancer Res. 70

      Pages: 1215-1224

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors2009

    • Author(s)
      Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N.
    • Journal Title

      Science 323

      Pages: 524-527

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1.2008

    • Author(s)
      Fukuhara S.
    • Journal Title

      Nat.Cell Biol. 10

      Pages: 513-526

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway.2008

    • Author(s)
      Koyama T.
    • Journal Title

      J.Biol.Chem. 283

      Pages: 24234-24244

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis.2008

    • Author(s)
      Kidoya H.
    • Journal Title

      EMBO J. 27

      Pages: 522-534

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation.2008

    • Author(s)
      Yasuda N.
    • Journal Title

      EMBO Rep 9

      Pages: 179-186

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 15-lipoxygenase-1 in the vasculature : expanding roles in angiogenesis.2008

    • Author(s)
      Mochizuki N.
    • Journal Title

      102

      Pages: 143-145

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single Common Mutation in the Cardiac Sodium Channel Gene SCN5A with Diverse Clinical Phenotypes.2008

    • Author(s)
      Makita N.
    • Journal Title

      J.Clin.Invest. 118

      Pages: 2219-2229

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-12008

    • Author(s)
      Fukuhara S
    • Journal Title

      Nat. Cell Biol. 10

      Pages: 513-526

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway2008

    • Author(s)
      Koyama T
    • Journal Title

      J. Biol. Chem. 283

      Pages: 24234-24244

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis2008

    • Author(s)
      Kidoya H
    • Journal Title

      EMBO J. 27

      Pages: 522-534

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation2008

    • Author(s)
      Yasuda N
    • Journal Title

      EMBO Rep 9

      Pages: 179-186

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 15-lipoxygenase-1 in the vasculature : expanding roles in angiogenesis2008

    • Author(s)
      Mochizuki N
    • Journal Title

      Circ. Res. 102

      Pages: 143-145

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single Common Mutation in the Cardiac Sodium Channel Gene SCN5A with Diverse Clinical Phenotypes2008

    • Author(s)
      Makita N
    • Journal Title

      J. Clin. Invest. 118

      Pages: 2219-2229

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] A ngiopoietin-1/Tie2- mediated vascular maturation and quiescence are reregulate by Dll4-Notch signaling.2010

    • Author(s)
      Naoki Mochizuki
    • Organizer
      Kloster Seeon Angiogenesis Meeting 2010.
    • Place of Presentation
      Kloster Seeon, Germany
    • Related Report
      2010 Final Research Report
  • [Presentation] Angiopoietin-1/Tie2-mediated vascular maturation and quiescence are reregulate by Dll4-Notch signaling2010

    • Author(s)
      Naoki Mochizuki
    • Organizer
      Kloster Seeon Angiogenesis Meeting 2010
    • Place of Presentation
      Kloster Seeon, Germany
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Sphiogosine-1 phosphate transporter in zebrafish.2009

    • Author(s)
      Mochizuki N.
    • Organizer
      European School of haematololgy Interdeciplinary conference.
    • Place of Presentation
      Helsinki
    • Year and Date
      2009-06-07
    • Related Report
      2010 Final Research Report
  • [Presentation] A Sphiogosine-1 phosphate transporter in zebrafish2009

    • Author(s)
      Mochizuki N
    • Organizer
      European School of haematololgy Interdeciplinary conference
    • Place of Presentation
      Helsinki
    • Year and Date
      2009-06-07
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/ncvc/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/ncvc/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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