Role of ubiquitin system in Xenopus gastrulation movements
| Project/Area Number |
20370090
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 原腸形成 / 細胞接着 / 細胞運動 / ユビキチン化 / Wntシグナル |
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| Research Abstract |
Paraxial protocadherin(PAPC) has been shown to be involved in gastrulation cell movements during early embryogenesis. It is first expressed in the dorsal marginal zone at early gastrula stage and subsequently restricted to paraxial mesoderm during gastrulation in Xenopus and zebrafish. Using Xenopus embryos, we found that PAPC is regulated also at the protein level is degraded and excluded from the plasma membrane in the axial mesoderm at late gastrula stage. Our findings suggest a novel mechanism of regulation of a cell adhesion protein and that this system plays a crucial role in vertebrate embryogenesis.
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Report
(4 results)
Research Products
(10 results)
