Functional Analysis of a peptide regulator in epidermal morphogenesis

• Project/Area Number: 20370091
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Kobe University (2011); National Institutes of Natural Sciences Okazaki Research Facilities (2008-2010)
• Principal Investigator: KAGEYAMA Yuji 神戸大学, 自然科学系先端融合研究環遺伝子実験センター, 准教授 (90335480)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: ショウジョウバエ / 発生遺伝 / 上皮細胞 / 形態形成 / 細胞骨格 / キイロショウジョウバエ / 短鎖ペプチド / 器官形成 / 転写制御 / 遺伝子発現制御

Research Abstract

polished rice(pri) encodes extremely small 11 or 32 aa-long peptides that do notinclude any signatures of secretion signal peptide sequences, and therefore its gene products should be of novel type of bioactive molecules. To elucidate molecular mechanisms underlying pri function, we found prigenetically interacts with shavenbaby(svb). svbencodes a transcription factor and is hydrolysed and activated only in the presence of PRI peptides.

Research Products

• [Journal Article] Coding vs non-coding: Translatability of short ORFs found in putative non-coding transcripts (2011)
  • Author(s): Yuji Kageyama, Kondo T and Hashimoto Y.
  • Journal Title: Biochimie Volume: 93 Pages: 1981-1986
  • Peer Reviewed
• [Journal Article] Coding vs non-coding : Translatability of short ORFs found in putativenon-coding transcripts (2011)
  • Author(s): Kageyama Y, Kondo T, Hashimoto Y
  • Journal Title: Biochimie Volume: 93 Pages: 1981-1986
  • Peer Reviewed
• [Journal Article] Small peptides switch the transcriptional activity of Shavenbaby during DrosophilaEmbryogenesis. (2010)
  • Author(s): Takefumi Kondo, Plaza, S.,Zanet, J., Benrabah, E., Valenti, P., Hashimoto, Y., Kobayashi, S., Payre, F. and Kageyama, Y.
  • Journal Title: Science Volume: 329 Pages: 336-339
  • Peer Reviewed
• [Journal Article] Small peptides switch the transcriptional activity of Shavenbaby during Drosophila Embryogenesis. (2010)
  • Author(s): Takefumi Kondo, Plaza, S., Zanet, J., Benrabah, E., Valenti, P., Hashimoto, Y., Kobayashi, S., Payre, F., Kageyama, Y.
  • Journal Title: Science 329 Pages: 336-339
  • Peer Reviewed
• [Journal Article] Small peptides switch the transcriptional activity of Shavenbaby during Drosophila Embryogenesis. (2010)
  • Author(s): Kondo, T., Plaza, S., Zanet, J., Benrabah, E., Valenti, P., Hashimoto, Y., Kobayashi, S., Payre, F., Kageyama, Y.
  • Journal Title: Science Volume: 329 Pages: 469-476
  • Peer Reviewed
• [Journal Article] Lilliputians get into the limelight - novel class of small peptide genes in morphogenesis (2008)
  • Author(s): Yoshiko Hashimoto, Kondo, K. and Kageyama, Y.
  • Journal Title: Develop. Growth Diff. Volume: 50
  • NAID: 10024400513
  • Peer Reviewed
• [Journal Article] MLE activates transcription via the minimal transactivation domain in Drosophila. (2008)
  • Author(s): Satoko Aratani., Kageyama, Y., Nakamura, A., Fujita, H., Fujii, R., Nishioka, K. and Nakajima, T
  • Journal Title: Int. J. Molec. Med. Volume: 21 Pages: 469-476
  • Peer Reviewed
• [Journal Article] Lilliputians get into the limelight - novel class of small peptide genes in morphogenesis. (2008)
  • Author(s): Yoshiko Hashimoto, Kondo, K., Kageyama, Y.
  • Journal Title: Develop.Growth Diff. 50 Pages: 269-276
  • NAID: 10024400513
  • Peer Reviewed
• [Journal Article] Lilliputians get into the limelight-novel class of small peptide genes in morphogenesis (2008)
  • Author(s): Yoshiko Hashimoto, Kondo, K., Kageyama, Y.
  • Journal Title: Develop. Growth Diff. 50
  • NAID: 10024400513
  • Peer Reviewed
• [Journal Article] MLE activates transcription via the minimal transactivation domain in Drosophila (2008)
  • Author(s): Satoko Aratani., Kageyama, Y., Nakamura, A., Fujita, H., Fujii, R., Nishioka, K., Nakajima, T.
  • Journal Title: Int. J. Molec. Med. 21 Pages: 469-476
  • Peer Reviewed
• [Presentation] A small peptide gene polished rice is essential for trichome formation and metamorphosis in Drosophila (2011)
  • Author(s): Yoshiko Hashimoto, Kaori Niimi, Takefumi Kondo, Yuji Kageyama
  • Organizer: 第44回日本発生生物学会年会シンポジウム
  • Place of Presentation: 沖縄コンベンションセンター(招待講演)
  • Year and Date: 2011-05-21
• [Presentation] A small peptide gene polished rice is essential for trichome formation and metamorphosis in Drosophila. (2011)
  • Author(s): Yoshiko Hashimoto, Kaori Niimi, Takefumi Kondo, Yuji Kageyama
  • Organizer: 第44回日本発生生物学会年会シンポジウム「Genetic Control of Morophogenesis」
  • Place of Presentation: 沖縄
• [Presentation] Small peptide regulators encoded in extremely short ORFs (2010)
  • Author(s): Yuji Kageyama
  • Organizer: 4th International Symposium on Nanomedicine
  • Place of Presentation: 岡崎カンファレンスセンター(愛知)
  • Year and Date: 2010-11-30
• [Presentation] 短鎖ペプチドによる転写因子の活性制御 (2010)
  • Author(s): 近藤武史、Serge Plaza、Jennifer Zanet, Emilie Benrabah, Philippe Valenti、橋本祥子、小林悟、Francois Payre、影山裕二
  • Organizer: 第12回日本RNA学会年会
  • Place of Presentation: 学術総合センター(東京)
  • Year and Date: 2010-07-28
• [Presentation] Asmall peptide gene, polished rice, participates in Drosophila ecdysone signal pathway. (2010)
  • Author(s): Yoshiko Hashimoto, Kaori Niimi, Takefumi Kondo, Yuji Kageyama.
  • Organizer: The 18th International Ecdysone Workshop
  • Place of Presentation: Academy of Science Conference Center(Czech)
  • Year and Date: 2010-07-19
• [Presentation] Small peptide regulators encoded in extremely short ORFs (2010)
  • Author(s): Yuji Kageyama
  • Organizer: 4th International Symposium on Nanomedicine
  • Place of Presentation: 岡崎
• [Presentation] 短鎖ペプチドによる転写因子の活性制御 (2010)
  • Author(s): 近藤武史、Serge Plaza、Jennifer Zanet、Emilie Benrabah、Philippe Valenti、橋本祥子、小林悟、Francois Payre、影山裕二
  • Organizer: 第12回日本 RNA 学会年会
  • Place of Presentation: 東京
• [Presentation] A small peptide gene, polished rice, participates in Drosophila ecdysone signal pathway (2010)
  • Author(s): Yoshiko Hashimoto, Kaori Niimi, Takefumi Kondo, Yuji Kageyama.
  • Organizer: The 18th International Ecdysone Workshop, Ceske Budejovice
  • Place of Presentation: Czech Republic
• [Presentation] 短鎖ペプチドによる転写因子の活性制御 (2010)
  • Author(s): 近藤武史、Serge Plaza、Jennifer Zanet、Emilie Benrabah、Philippe Valenti、橋本祥子、小林悟、Francois Payre、影山裕二
  • Organizer: 第12回日本RNA学会年会
  • Place of Presentation: 東京
• [Presentation] polished rice that encodes 11 and 32 aa-peptide regulates subnuclear localization and activity of transcription factor Shavenbaby in denticle formation (2009)
  • Author(s): Takefumi Kondo, Hashimoto, Y., Kageyama, Y.
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2009-03-05
• [Presentation] polished rice, a versatile gene regulator in Drosophila development (2009)
  • Author(s): Yuji Kageyama, Hashimoto, Y., Kondo, T.
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2009-03-05
• [Presentation] polished rice functions in ecdysone signaling. (2009)
  • Author(s): Yoshiko Hashimoto, Kondo, T. and Kageyama, Y.
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: Ecdysone Workshop, Chicago (USA)
  • Year and Date: 2009-03-04
• [Presentation] polished rice functions in ecdysone signaling (2009)
  • Author(s): Yoshiko Hashimoto, Kondo, T., Kageyama, Y.
  • Organizer: 50th Annual Drosophila Research Conference, Ecdysone Workshop
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2009-03-04
• [Presentation] polished ricethat encodes 11- and 32-aa peptide regulates subnuclear localization and activity of transcription factor Shavenbaby during trichome formation. (2009)
  • Author(s): Takefumi Kondo, Yoshiko Hashimoto, Yuji Kageyama
  • Organizer: The 9th Japanese Drosophila Research Conference
  • Place of Presentation: 掛川
• [Presentation] polished rice that encodes 11 and 32 aa-peptide regulates subnuclear localization and activity of transcription factor Shavenbaby in denticle formation. (2009)
  • Author(s): Takefumi Kondo, Hashimoto, Y. and Kageyama, Y
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: Chicago (USA)
• [Presentation] polished rice, a versatile gene regulator in Drosophiladevelopment. (2009)
  • Author(s): Yuji Kageyama, Hashimoto, Y. and Kondo, T.
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: Chicago (USA)
• [Presentation] polished rice functions in ecdysone signaling. (2009)
  • Author(s): Yoshiko Hashimoto, Kondo, T., Kageyama, Y.
  • Organizer: 50th Annual Drosophila Research Conference, Ecdysone Workshop
  • Place of Presentation: Chicago (USA)
• [Presentation] polished rice, a versatile gene regulator in Drosophila development. (2009)
  • Author(s): Yuji Kageyama, Hashimoto, Y., Kondo, T.
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: Chicago (USA)
• [Presentation] polished rice that encodes 11- and 32-aa peptide regulates subnuclear localization and activity of transcription factor Shavenbaby during trichome formation (2009)
  • Author(s): Takefumi Kondo, Yoshiko Hashimoto, Yuji Kageyama
  • Organizer: The 9th Japanese Drosophila Research Conference
  • Place of Presentation: ヤマハリゾートつま恋(静岡県掛川市)
• [Presentation] Coding vs. Non-coding : Lessons from Drosophila (2008)
  • Author(s): 影山裕二
  • Organizer: 第30回日本分子生物学会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] ショウジョウバエMRE32 RNAは雌特異的に羽化のタイミングを制御している (2008)
  • Author(s): 影山裕二, 稲垣幸, 橋本祥子
  • Organizer: 第10回日本RNA学会年会
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-23
• [Presentation] 上皮形態形成を制御する短鎖ペプチド (2008)
  • Author(s): 近藤武史、橋本祥子、影山裕二
  • Organizer: 第41回日本発生生物学会年会サテライトシンポジウム
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-27
• [Presentation] A short peptide gene polished rice controls Drosophila metamorphosis through intercellular communication (2008)
  • Author(s): Yoshiko Hashimoto, Kondo, T., Kageyama, Y.
  • Organizer: 第41回日本発生生物学会年会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-26
• [Presentation] Coding vs. Non-coding: Lessons from Drosophila. (2008)
  • Author(s): 影山裕二
  • Organizer: 第31回日本分子生物学会シンポジウム「 Expansion of non-protein-coding RNA inventory」
  • Place of Presentation: 神戸
• [Presentation] ショウジョウバエMRE32RNA は雌特異的に羽化のタイミングを制御している (2008)
  • Author(s): 影山裕二、稲垣幸、橋本祥子
  • Organizer: 第10回日本 RNA 学会年会
  • Place of Presentation: 札幌
• [Presentation] A short peptide gene polished ricecontrols Drosophilametamorphosis through intercellular communication. (2008)
  • Author(s): Yoshiko Hashimoto, Kondo, T. and Kageyama, Y.
  • Organizer: 第41回日本発生生物学会年会
  • Place of Presentation: 徳島
• [Presentation] A small peptide gene polished riceregulates imaginal development viaintercellular communication. (2008)
  • Author(s): uji Kageyama, Hashimoto, Y. and Kondo, T.
  • Organizer: 49th Annual Drosophila Research Conference
  • Place of Presentation: San Diego (USA)
• [Presentation] Coding vs.Non-coding : Lessons from Drosophila. (2008)
  • Author(s): 影山裕二
  • Organizer: 第30回日本分子生物学会シンポジウム
  • Place of Presentation: 神戸
• [Presentation] ショウジョウバエMRE32 RNA は雌特異的に羽化のタイミングを制御している (2008)
  • Author(s): 影山裕二、稲垣幸、橋本祥子
  • Organizer: 第10回日本RNA学会年会
  • Place of Presentation: 札幌
• [Presentation] A short peptide gene polished rice controls Drosophila metamorphosis through intercellular communication. (2008)
  • Author(s): Yoshiko Hashimoto, Kondo, T.,Kageyama, Y.
  • Organizer: 第41回日本発生生物学会年会
  • Place of Presentation: 徳島
• [Book] 機能性 RNA の分子生物学 河合剛太・清澤秀孔編(クバプロ) 第IV 章 mRNA 型 non-coding RNA (2010)
  • Author(s): 影山裕二
  • Publisher: クバプロ
• [Book] 分子昆虫学-ポストゲノムの昆虫研究-(畠山正統他 編) (2009)
  • Author(s): 影山裕二
  • Publisher: 共立出版
• [Book] 分子昆虫学-ポストゲノムの昆虫研究-(第2章3節および5節担当) (2009)
  • Author(s): 影山裕二
  • Total Pages: 29
  • Publisher: 共立出版
• [Remarks]
  • URL: http://www.nibb.ac.jp/cib1/kageyama/