Evolution of sex-determining systems in vertebrates

• Project/Area Number: 20370093
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Evolutionary biology
• Research Institution: Kitasato University
• Principal Investigator: ITO Michihiko (ITO Michihio) 北里大学, 理学部, 准教授 (90240994)
• Co-Investigator(Kenkyū-buntansha): TAMURA Kei 北里大学, 理学部, 助教 (50458767)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
• Keywords: 性決定遺伝子 / 脊椎動物 / 性染色体 / 生殖巣 / 遺伝子進化 / 性決定 / DMRT1 / SRY / パラログ / 共進化 / 新機能付加 / 両生類 / 発現ヒエラルキ / ブロモーター / 卵巣 / 発現ヒエラルキー / プロモーター

Research Abstract

We analyzed and discussed sex-determining systems during vertebrate evolution, proposing a hypothesis that there might be a basic male sex-determining system driven by DMRT1 in non-mammalian vertebrates and that it might be changed into a SRY-SOX9 male sex-determining system during mammalian evolution. We also proposed a coevolution model of sex-determining genes and sex chromosomes, in which undifferentiated sex chromosomes easily allow replacement of a sex-determining gene with another new one, while specialized sex chromosomes are restricted a particular sex-determining gene.

Research Products

• [Journal Article] Molecular evolution of vertebrate sex-determining genes (2012)
  • Author(s): Mawaribuchi, S. Yoshimoto, S., Ohashi, S., Takamatsu, N. and Ito, M.
  • Journal Title: Chromosome Res Volume: 20 Pages: 139-151
  • Peer Reviewed
• [Journal Article] Molecular evolution of vertebrate sex-determining genes (2012)
  • Author(s): Shuuji Mawaribuchi
  • Journal Title: Chromosome Research Volume: 20 Issue: 1 Pages: 139-151
  • DOI: 10.1007/s10577-011-9265-9
  • Peer Reviewed
• [Journal Article] Apoptotic and survival signaling mediated through dearth receptor members during metamorphosis in the African clawed frog Xenopus laevis (2012)
  • Author(s): Michihiko Ito
  • Journal Title: General Comparative Endocrinology Volume: 176 Issue: 3 Pages: 461-464
  • DOI: 10.1016/j.ygcen.2011.12.037
  • Peer Reviewed
• [Journal Article] Serine-threonine kinase 38 is regulated by glycogen synthase kinase-3 and modulates oxidative stress-induced cell death (2012)
  • Author(s): Atsushi Enomoto
  • Journal Title: Free Radical Biology and Medicine Volume: 52 Issue: 2 Pages: 507-515
  • DOI: 10.1016/j.freeradbiomed.2011.11.006
  • Peer Reviewed
• [Journal Article] A ZZ/ZW-type sex determination in Xenopus leavis (2011)
  • Author(s): Yoshimoto, S., and Ito, M.
  • Journal Title: FEBS J Volume: 278 Pages: 1020-1026
  • Peer Reviewed
• [Journal Article] A ZZ/ZW-type sex determination in Xenopus leavis. (2011)
  • Author(s): Yoshimoto, S., Ito, M.
  • Journal Title: FEBS J. 278 Pages: 1020-1026
• [Journal Article] A ZZ/ZW-type sex determintion in Xenopus leavis (2011)
  • Author(s): Shin Yoshimoto
  • Journal Title: FEBS Journal Volume: 278 Pages: 1020-1026
  • Peer Reviewed
• [Journal Article] Opposite roles of DMRT1 and its W-linked paralogue DM-W, in sexual dimorphism of Xenopus laevis : Implications of a ZZ/ZW-type sex-determining system (2010)
  • Author(s): Yoshimoto, S., Ikeda, N., Izutsu, Y., Shiba, T., Takamatsu, N. and Ito, M.
  • Journal Title: Development Volume: 137 Issue: 15 Pages: 2519-2526
  • DOI: 10.1242/dev.048751
  • Peer Reviewed
• [Journal Article] Function and molecular evolution of mammalian Sox15, a singleton in the SoxG group of transcription factors (2010)
  • Author(s): Ito, M.
  • Journal Title: Int J. Biochem. Cell Biol Volume: 42 Issue: 3 Pages: 449-452
  • DOI: 10.1016/j.biocel.2009.10.023
  • Peer Reviewed
• [Journal Article] Opposite roles of DMRT1 and its W-linked paralogue, DM-W, in sexual dimorphism of Xenopus laevis : Implications of a ZZ/ZW-type sex-determining system. (2010)
  • Author(s): Yoshimoto, S., Ikeda, N., Izutsu, Y., Shiba, T., Takamatsu, N., Ito, M.
  • Journal Title: Development 137 Pages: 2519-2526
• [Journal Article] Function and molecular evolution of mammalian Sox15, a singleton in the SoxG group of transcription factors (2010)
  • Author(s): Ito, M.
  • Journal Title: Int.J.Biochem.Cell Biol 42 Pages: 449-452
• [Journal Article] Opposite roles of DMRT1 and its W-linked paralogue, DM-W, in sexual dimorphism of Xenopus laevis : Implications of a ZZ/ZW-type sex-determining system. (2010)
  • Author(s): Shin Yoshimoto
  • Journal Title: Development Volume: 137 Pages: 2519-2526
  • Peer Reviewed
• [Journal Article] TNF-related apoptosis-inducing ligand1(TRAIL1)enhances the transition of red blood cells from the larval to adult type during metamorphosis in Xenopus (2010)
  • Author(s): Kei Tamura
  • Journal Title: Blood VOL.115 Pages: 850-859
  • Peer Reviewed
• [Journal Article] Function and molecular evolution of mammalian Sox15, a singleton in the SoxG group of transcription factors (2010)
  • Author(s): Michihiko Ito
  • Journal Title: International Journal of Biochemistry & Cell Biology 42 Pages: 449-452
  • Peer Reviewed
• [Journal Article] Xenopus W-linked DM-W induces Foxl2 and Cyp19 expression during ovary formation (2009)
  • Author(s): Okada, E., Yoshimoto, S., Ikeda, N., Kanda, H., Tamura, K., Shiba, T., Takamatsu, N., Ito, M.
  • Journal Title: Sex. Dev. Volume: 3 Pages: 38-42
  • Peer Reviewed
• [Journal Article] アフリカツメガエルのZZ/ZW型性決定の分子機構-性決定システム進化- (2009)
  • Author(s): 伊藤道彦
  • Journal Title: 比較内分泌学 Volume: 35(134) Pages: 165-174
  • URL: https://www.jstage.jst.go.jp/article/nl2008jsce/35/134/35_134_165/_article/-char/ja/
• [Journal Article] アフリカツメガエルの性決定遺伝子DM-W.脊椎動物初の♀決定遺伝子 (2009)
  • Author(s): 伊藤道彦、吉本真
  • Journal Title: 生物の科学<遺伝> Volume: 63 Pages: 38-43
  • URL: http://ci.nii.ac.jp/naid/40016416603
• [Journal Article] Xenopus W-linked DM-W induces Foxl2 and Cyp19 expression during ovary formation (2009)
  • Author(s): Okada, E., Yoshimoto, S., Ikeda, N., Kanda, H., Tamura, K., Shiba, T., Takamatsu, N., Ito, M.
  • Journal Title: Sex.Dev 3 Pages: 38-42
• [Journal Article] アフリカツメガエルのZZ/ZW型性決定の分子機構-性決定システム進化- (2009)
  • Author(s): 伊藤道彦
  • Journal Title: 比較内分泌学 35(134) Pages: 165-174
• [Journal Article] アフリカツメガエルの性決定遺伝子DM-W-脊椎動物初の♀決定遺伝子. (2009)
  • Author(s): 伊藤道彦、吉本真
  • Journal Title: 生物の科学<遺伝> 63 Pages: 38-43
• [Journal Article] アフリカツメガエルのZZ/ZW型性決定の分子機構-性決定システム進化- (2009)
  • Author(s): 伊藤道彦
  • Journal Title: 比較内分泌学 35巻 Pages: 165-174
• [Journal Article] Xenopus W-linked DM-W induces Foxl2 and Cyp19 expression during ovary formation. (2009)
  • Author(s): Ema Okada
  • Journal Title: Sexual Development 3(in press)
  • Peer Reviewed
• [Journal Article] Diversity in the origins of sex chromosomes in anurans inferred from comparative mapping of sexual differentiation genes for three species of the Raninae and Xenopodinae. (2008)
  • Author(s): Yoshinobu Uno
  • Journal Title: Chromosome Research 16 Pages: 999-1011
  • Peer Reviewed
• [Presentation] Opposite roles of DMRT1 and its W-linked paralogue, DM-W, in the ZZ/ZW-type sex-determination in Xenopus/eavis (2011)
  • Author(s): Michihiko Ito
  • Organizer: North American Society for Comparative Endocrinology
  • Place of Presentation: Ann Arbor (USA)
  • Year and Date: 2011-07-14
• [Presentation] Opposite roles of DMRT1 and its W-linked paraloue the ZZ/ZW-type sex-determination in Xenopus laevis. (2011)
  • Author(s): Ito, M., Yoshimoto, S., Mawaribuchi, S., Ikeda, N., Fujitani, K., Tamura, K., and Takamatsu, N
  • Organizer: NASCE
  • Place of Presentation: Ann Arbor(USA)
• [Presentation] Evolution of DMRT1-driven male sex-determining system (2010)
  • Author(s): Ito, M., Yoshimoto, S., Mawaribuchi, S., Ikeda, N., Takamatsu, N
  • Organizer: Society of Molecular Biology and Evolution
  • Place of Presentation: Lyon(France)
• [Presentation] Evolution of DMRT1-driven male sex-determining system. (2010)
  • Author(s): Ito, M., Yoshimoto, S., Mawaribuchi, S., Ikeda, N., Takamatsu, N.
  • Organizer: Society of Molecular Biology and Evolution.
  • Place of Presentation: Lyon(France).
• [Presentation] アフリカツメガエルWリンクの性(♀)決定遺伝子DM-W (2009)
  • Author(s): 伊藤道彦
  • Organizer: 日本動物学会
  • Place of Presentation: グランシップ(静岡県)
  • Year and Date: 2009-09-17
• [Presentation] A W-linked gene DM-W could induce female sex as a sex(ovary)-determining gene in Xenopus laevis that has the ZZ/ZW-type sex-determining system (2009)
  • Author(s): Michihiko Ito
  • Organizer: The 16th International Congress of Comparative Endocrinology
  • Place of Presentation: The University of HongKong(Hong Kong ;)
  • Year and Date: 2009-06-23
• [Presentation] A W-linked gene DM-W could determine female development as a sex(ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex determining system. (2009)
  • Author(s): Michihiko Ito
  • Organizer: Fifth International symposium on the biology of vertebrate sex determination
  • Place of Presentation: Royal Kona Resort(Hawaii)
  • Year and Date: 2009-04-21
• [Presentation] アフリカツメガエルWリンクの性(♀)決定遺伝子DM-W (2009)
  • Author(s): 伊藤道彦
  • Organizer: 第80回日本動学会大会
  • Place of Presentation: 静岡
• [Presentation] A W-linked gene DM-W could induce female sex as a sex(ovary)-determining gene in Xenopus laevis that has the ZZ/ZW-type sex-determining system (2009)
  • Author(s): Ito, M., Yoshimoto, S., Takamatsu, N
  • Organizer: The 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong
• [Presentation] A W-linked gene DM-W could determine female development as a sex(ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex determining system (2009)
  • Author(s): Ito, M., Yoshimoto, S., Takamatsu, N
  • Organizer: Fifth International Symposium on the biology of vertebrate sex determination
  • Place of Presentation: Hawaii(USA)
• [Presentation] アフリカツメガエルWリンクの性(♀)決定遺伝子DM-W (2009)
  • Author(s): 伊藤道彦
  • Organizer: 第80回日本動学会大会
  • Place of Presentation: 静岡(招待講演)
• [Presentation] A W-linked gene DM-W could induce female sex as a sex(ovary)-determining gene in Xenopus laevis that has the ZZ/ZW-type sex-determining system. (2009)
  • Author(s): Ito, M., Yoshimoto, S., Takamatsu, N.
  • Organizer: The 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong
• [Presentation] A W-linked gene DM-W could determine female development as a sex (ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex determining system. (2009)
  • Author(s): Ito, M., Yoshimoto, S., Takamatsu, N.
  • Organizer: Fifth International Symposium on the biology of vertebrate sex determination.
  • Place of Presentation: Hawaii
• [Presentation] A W-linked DM-W is a likely sex (ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex-determining system. (2008)
  • Author(s): Michihiko Ito
  • Organizer: International Symposium for Gonad and Brain Sex Differentiation
  • Place of Presentation: Sea Hawk Hotel (Fukuoka)
  • Year and Date: 2008-09-14
• [Presentation] A W-linked DM-W gene may be a sex (ovary)-detremining gene in Xenopus laevis (2008)
  • Author(s): Michihiko Ito
  • Organizer: 12th International Xenopus Conference
  • Place of Presentation: Leiwen (Germany)
  • Year and Date: 2008-09-09
• [Presentation] A W-linked DM-W is a likely sex(ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex-determining system (2008)
  • Author(s): Ito, M
  • Organizer: International Symposium for Gonad and Brain Sex Differentiation
  • Place of Presentation: Fukuoka
• [Presentation] A W-linked DM-W is a likely sex (ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex-determining system. (2008)
  • Author(s): Ito, M.
  • Organizer: International Symposium for Gonad and Brain Sex Differentiation.
  • Place of Presentation: Fukuoka