| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Research Abstract |
The Arabidopsis lic1 mutants developed lesions by non-adapted pathogens, and the gene responsible for the mutants encodes a MACPF domain protein with unknown function. In this study, we showed that lesion development in the lic1 mutants is not due to pathogen entry, indicating that LIC1 is required for regulation of cell death in nonhost defense, and that PEN2-dependent synthesis of anti-microbial metabolite is involved in LIC1-mediated regulation for cell death. We also indicate that LIC1 is localized in plasma membrane, and functions together with LIC1 homologs. Furthermore, we found that EDR1 and GSH1 are involved in nonhost resistance.
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