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Development of microbial production system using bioreduction system

Research Project

Project/Area Number 20380051
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied microbiology
Research InstitutionKyoto University

Principal Investigator

KATAOKA Michihiko  Kyoto University, 生命環境科学研究科, 教授 (90252494)

Co-Investigator(Kenkyū-buntansha) 小川 順  京都大学, 農学研究科, 教授 (70281102)
萩下 大郎  京都大学, 農学研究科, 准教授 (20432346)
清水 昌  京都大学, 農学研究科, 教授 (70093250)
Co-Investigator(Renkei-kenkyūsha) OGAWA Jun  京都大学, 農学研究科, 教授 (70281102)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywordsバイオ還元 / 不斉還元 / 補酵素再生 / 旧黄色酵素 / モノオキシゲナーゼ / ラクトン
Research Abstract

Bioreduction system using an E. coli transformant co-expressing NAD(P)H-dependent enzyme and cofactor regeneration enzyme genes was applied to the production of other useful compounds. The reactions requiring NAD(P)H as a cofactor, such as C=C bond reductions and monooxigenation were exammined.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (71 results)

All 2011 2010 2009 2008

All Journal Article (25 results) (of which Peer Reviewed: 23 results) Presentation (39 results) Book (7 results)

  • [Journal Article] Directed evolution of an aminoalcohol dehydrogenase for efficient production of double chiral aminoalcohols2011

    • Author(s)
      N. Urano, S. Fukui, S. Kumashiro, T. Ishige, S. Kita, K. Sakamoto, M.Kataoka, S.Shimizu
    • Journal Title

      J.Biosci.Bioeng. 111

      Pages: 266-271

    • NAID

      110008593154

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis around aminoalcohol dehydrogenase gene of Rhodococcus erythropolis MAK154 : a putative GntR transcription factor in transcriptional regulation. Appl.2011

    • Author(s)
      N.Urano, M.Kataoka, T. Ishige, S. Kita, K. Sakamoto, S.Shimizu
    • Journal Title

      Microbiol.Biotechnol. 89

      Pages: 739-746

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis around aminoalcohol dehydrogenase gene of Rhodococcus erythropolis MAK154 : a putative GntR transcription factor in transcriptional regulation.2011

    • Author(s)
      N.Urano, M.Kataoka, T.Ishige, S.Kita, K.Sakamoto, S.Shimizu
    • Journal Title

      Appl.Microbiol.Biotechnol

      Volume: 89 Pages: 739-746

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Directed evolution of an aminoalcohol dehydrogenase for efficient production of double chiral aminoalcohols2011

    • Author(s)
      N.Urano, S.Fukui, S.Kumashiro, T.Ishige, S.Kita, K.Sakamoto, M.Kataoka, S.Shimizu
    • Journal Title

      J.Biosci.Bioeng

      Volume: 111 Pages: 266-271

    • NAID

      110008593154

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloning, sequencing and expression analysis of a gene encoding alcohol oxidase in Paenibacillus sp. AIU 311.2010

    • Author(s)
      Y. Sasaki, M.Kataoka, N.Urano, J. Ogawa, A. Iwasaki, J. Hasegawa, K. Isobe, S.Shimizu
    • Journal Title

      J.Biosci.Bioeng. 110

      Pages: 147-151

    • NAID

      110007700561

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the ubiquinone binding site in alternative NADH-quinone oxidoreductase of Saccharomyces cerevisiae by photoaffinity labeling.2010

    • Author(s)
      M. Murai, T. Yamashita, M. Senoh, Y. Mashimo, M.Kataoka, H. Kosaka, A. Matsuno-Yagi, T. Yagi, H. Miyoshi
    • Journal Title

      Biochemistry. 49

      Pages: 2973-2980

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 不斉水素添加触媒としての「旧黄色酵素」の機能開発2010

    • Author(s)
      片岡道彦、浦野信行、堀田彰一朗、宮川拓也、田之倉優、清水昌
    • Journal Title

      酵素工学ニュース 第64号

      Pages: 11-166

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characterization of the ubiquinone binding site in alternative NADH-quinone oxidoreductase of Saccharomyces cerevisiae by photoaffinity labeling.2010

    • Author(s)
      M.Murai, T.Yamashita, M.Senoh, Y.Mashimo, M.Kataoka, H.Kosaka, A.Matsuno-Yagi, T.Yagi, H.Miyoshi
    • Journal Title

      Biochemistry

      Volume: 49 Pages: 2973-2980

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloning, sequencing and expression analysis of a gene encoding alcohol oxidase in Paenibacillus sp.AIU 311.2010

    • Author(s)
      Y.Sasaki, M.Kataoka, N.Urano, J.Ogawa, A.Iwasaki, J.Hasegawa, K.Isobe, S.Shimizu
    • Journal Title

      J.Biosci.Bioeng

      Volume: 110 Pages: 147-151

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不斉水素添加触媒としての「旧黄色酵素」の機能開発2010

    • Author(s)
      片岡道彦、浦野信行、堀田彰一朗、宮川拓也、田之倉優、清水昌
    • Journal Title

      酵素工学ニュース

      Volume: 第64号 Pages: 11-16

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Expression, purification, crystallization and preliminary X-ray analysis of conjugated polyketone reductase C2 (CPR-C2) from Candida parapsilosis IFO 0708.2009

    • Author(s)
      A. Yamamura, S. Maruoka, J. Ohtsuka, T.Miyakawa, K. Nagata, M.Kataoka, N. Kitamura, S.Shimizu, M.Tanokura
    • Journal Title

      Acta Crystal. F65

      Pages: 1145-1148

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary X-ray analysis of the NADPH-dependent 3-quinuclidinone reductase from Rhodotorula rubra.2009

    • Author(s)
      D. Takeshita, M.Kataoka, T.Miyakawa, K. Miyazono, A. Uzura, K. Nagata, S.Shimizu, M.Tanokura
    • Journal Title

      Acta Crystal. F65

      Pages: 645-647

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Steroselective synthesis of (R)-3-quinuclidinol through asymmetric reduction of 3-quinuclidinone with NADPH-dependent 3-quinuclidinone reductase from Rhodotorula rubra.2009

    • Author(s)
      A. Uzura, F. Nomoto, A. Sakoda, Y. Nishimoto, M.Kataoka, S.Shimizu
    • Journal Title

      Appl.Microbiol.Biotechnol. 83

      Pages: 617-626

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production and characterization of alcohol oxidase from Penicillium purpurescens AIU063.2009

    • Author(s)
      K. Isobe, T. Takahashi, M.Kataoka, J. Ogawa, S.Shimizu
    • Journal Title

      J.Biosci.Bioeng. 107

      Pages: 108-112

    • NAID

      110007110228

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective synthesis of (R)-3-quinuclidinol through asymmetric reduction of 3-quinuclidinone with 3-quinuclidinone reductase of Rhodotorula rubra2009

    • Author(s)
      Uzura A, Nomoto F, Sakoda A, Nishimoto Y, Kataoka M, Shimizu S.
    • Journal Title

      Appl.Microbiol.Biotechnol 83

      Pages: 617-626

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary X-ray analysis of the NADPH-dependent 3-auinuclidinone reductase from Rhodotorula rubra2009

    • Author(s)
      Takeshita D, Kataoka M, Miyakawa T, Miyazono K, Uzura A, Nagata K, Shimizu S, Tanokura M.
    • Journal Title

      Acta Crystallogr.Sect.F Struct.Biol.Cryst Commun 65

      Pages: 645-647

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression, purification, crystallization and preliminary X-ray analysis of conjugated polyketone reductase C2 (CPR-C2) from Candida parapsilosis IFO 07082009

    • Author(s)
      Yamamura A, Maruoka S, Ohtsuka J, Miyakawa T, Nagata K, Kataoka M, Kitamura N, Shimizu S, Tanokura M.
    • Journal Title

      Acta Crystallogr.Sect.F Struct.Biol.Cryst Common 65

      Pages: 1145-1148

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification and characterization of a new aldehyde oxidase from Pseudomonas sp. AIU 362.2008

    • Author(s)
      Y. Sasaki, K. Isobe, M.Kataoka, J. Ogawa, A. Iwasaki, J. Hasegawa, S.Shimizu
    • Journal Title

      J.Biosci.Bioeng. 106

      Pages: 297-302

    • NAID

      110006950582

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and expression of the L-1-amino-2-propanol dehydrogenase gene from Rhodococcus erythropolis, and its application to double chiral compound production.2008

    • Author(s)
      M.Kataoka, T. Ishige, N.Urano, Y. Nakamura, E. Sakuradani, S. Fukui, S. Kita, K. Sakamoto, S.Shimizu
    • Journal Title

      Appl.Microbiol.Biotechnol. 80

      Pages: 597-604

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldehyde oxidase carrying an unusual subunit structure from Pseudomonas sp. MX-058.2008

    • Author(s)
      R. Thiwthong, M.Kataoka, A. Iwasaki, H. Watanabe, J. Hasegawa, K. Isobe, S.Shimizu
    • Journal Title

      Microbial. Biotechnol. 1

      Pages: 395-402

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Superoxide dismutase exhibit oxidase activity on aldehyde alcohols similar to alcohol oxidase from Paenibacillus sp. AIU311.2008

    • Author(s)
      K. Isobe, A. Kato, Y. Sasaki, M.Kataoka, J. Ogawa, A. Iwasaki, J. Hasegawa, S.Shimizu
    • Journal Title

      J.Biosci.Bioeng. 105

      Pages: 666-670

    • NAID

      110006792545

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari : Carpoglyphidae).2008

    • Author(s)
      K. Noge, N. Kato, N. Mori, M.Kataoka, C. Tanaka, Y. Yamasue, R. Nishida, Y. Kuwahara
    • Journal Title

      FEBS J. 275

      Pages: 2807-2817

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and expression of the L-1-amino-2-propanol dehydrogenase gene from Rhodococcus erythropolis, and its application to double chiral compound production2008

    • Author(s)
      Kataoka, M., et al.
    • Journal Title

      Appl. Microbiol. Biotechnol. 80

      Pages: 597-604

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldehyde oxidase carrying an unusual subunit structure from Pseudomonas sp. MX-0582008

    • Author(s)
      Thiwthong, R., et al.
    • Journal Title

      Microbial Biotechnol. 1

      Pages: 395-402

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari : Carpoglyphidae)2008

    • Author(s)
      Noge, K., et al.
    • Journal Title

      FEBS J. 275

      Pages: 2807-2817

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] A putative TetR transcription factor in transcriptional regulation of L-pantoyl lactone dehydrogenase gene of Rhodococcus erythropolis2011

    • Author(s)
      D. Si, N.Urano, S.Shimizu, M.Kataoka
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 環境調和型バイオプロセスに有用な微生物酵素の構造機能解析-キラル化合物合成酵素を中心として-2011

    • Author(s)
      片岡道彦、宮川拓也、田之倉優、清水昌
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 基質特異性の異なる2種の旧黄色酵素の構造情報に基づく機能改変2011

    • Author(s)
      片岡道彦、堀田彰一朗、中川拓哉、北村苗穂子、宮川拓也、大塚淳、永田宏次、田之倉優、清水昌
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] キラル化合物合成に応用可能な2種の旧黄色酵素の結晶構造解析とその異なる基質特異性の構造基盤2011

    • Author(s)
      堀田彰一朗、片岡道彦、北村苗穂子、宮川拓也、大塚淳、永田宏次、清水昌、田之倉優
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] カルボニル還元酵素S1の基質認識機構の構造学的解析2010

    • Author(s)
      諏訪陽一、片岡道彦、イマイファビアナリカ、永井貴大、北村苗穂子、宮川拓也、岡井公彦、清水昌、田之倉優
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] カルボニル還元酵素S1の基質認識機構の構造学的解析2010

    • Author(s)
      諏訪陽一、片岡道彦、イマイファビアナリカ、永井貴大、北村苗穂子、宮川拓也、岡井公彦、清水昌、田之倉優
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      宮城
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] A Novel Aocohol Oxidase from Paenibacillus sp. AIU 311 and Its Application2010

    • Author(s)
      K. Isobe, Y.Sasaki, M.Kataoka, N.Urano, J.Ogawa, A.Iwasaki, J.Hasegawa, S.Shimizu
    • Organizer
      14th International Biotechnology Symposium and Exhibition
    • Place of Presentation
      Italy
    • Year and Date
      2010-09-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 炭素二重結合を不斉水素化する2種の旧黄色酵素の構造機能解析2010

    • Author(s)
      片岡道彦、浦野信行、北村苗穂子、堀田彰一朗、宮川拓也、大塚淳、永田宏次、田之倉優、清水昌
    • Organizer
      2010年度酵素・補酵素研究会
    • Place of Presentation
      福岡
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] カルボニル還元酵素S1の基質認識機構の構造学的解析2010

    • Author(s)
      諏訪陽一、片岡道彦、イマイファビアナリカ、永井貴大、北村苗穂子、宮川拓也、岡井公彦、永田宏次、清水昌、田之倉優
    • Organizer
      第19回日本バイオイメージング学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 炭素二重結合を不斉水素化する2種の旧黄色酵素の構造機能解析2010

    • Author(s)
      片岡道彦、浦野信行、北村苗穂子、堀田彰一朗、宮川拓也、大塚淳、永田宏次、田之倉優、清水昌
    • Organizer
      食品酵素化学研究会第10回学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] D-パントイルラクトン合成酵素CPR-C2の機能改変に向けたX線結晶構造解析2010

    • Author(s)
      山村昭裕、丸岡慎太郎、大塚淳、宮川拓也、永田宏次、片岡道彦、北村苗穂子、清水昌、田之倉優
    • Organizer
      第10回日本蛋白質化学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] キラル化合物合成に有用な2種類の旧黄色酵素の結晶構造解析と基質特異性に関する構造基盤2010

    • Author(s)
      堀田彰一朗、片岡道彦、北村苗穂子、宮川拓也、大塚淳、永田宏次、清水昌、田之倉優
    • Organizer
      第10回日本蛋白質化学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] キラル化合物合成に有用な2種類の旧黄色酵素の結晶構造解析と基質特異性に関する構造基盤2009

    • Author(s)
      堀田彰一朗、片岡道彦、北村苗穂子、宮川拓也、大塚淳、永田宏次、清水昌、田之倉優
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Paenibacillus sp. AIU311が産生するアルデヒドアルコールに特異的なオキシダーゼ2009

    • Author(s)
      礒部公安、加藤彩子、佐々木康孝、浦野信行、片岡道彦、小川順、岩崎晃、長谷川淳三、清水昌
    • Organizer
      生体触媒化学シンポジウム
    • Place of Presentation
      香川
    • Year and Date
      2009-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Old Y ellow Enzymes : Powerful biocatalyst for the asymmetric hydrogenation of C=C bond2009

    • Author(s)
      M.Kataoka, F.Kuwabara, N.Urano, S. Kamishikiryo, S.Shimizu
    • Organizer
      BioMicroWorld 2009
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2009-12-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Paenibacillus属細菌由来グリコールアルデヒドオキシダーゼ遺伝子のクローニングと大腸菌での発現E.coli菌体によるグリコールアルデヒドのオキサールへの変換2009

    • Author(s)
      佐々木康孝、礒部公安、浦野信行、片岡道彦、小川順、岩崎晃、長谷川淳三、清水昌
    • Organizer
      日本農芸化学会東北支部
    • Place of Presentation
      岩手
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Crystal structure of Escherichia coli low-specific L-threonine aldolase2009

    • Author(s)
      Fabiana Lica Imai, M.Kataoka, T.Miyakawa, K. Miyazono, M.Okai, K.Nagata, S.Shimizu, M. Tanokura
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Bioreduction system for chiral technology2009

    • Author(s)
      Michihiko Kataoka, Nobuyuki Urano, Nahoko Kitamura, Sakayu Shimizu
    • Organizer
      15th German-Japanese Workshop on Enzyme Technology
    • Place of Presentation
      University of Rostock, Germany
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bioreduction system for chiral technology-the stereoselective synthesis of (R)-3-quinuclidinol-2009

    • Author(s)
      片岡道彦, 浦野信行, 北村苗穂, 清水昌
    • Organizer
      15th German-Japanese Workshop on Enzyme Technology
    • Place of Presentation
      Germany
    • Year and Date
      2009-09-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Two novel carbonyl reductases from yeast and bacterial strains, and their application to the stereoselective synthesis of (R)-3-quinuclidinol2009

    • Author(s)
      M.Kataoka, A. Uzura, F.Nomoto, N.Urano, N.Kitamura, S.Shimizu
    • Organizer
      Enzyme Engineering XX
    • Place of Presentation
      The Netherlands
    • Year and Date
      2009-09-20
    • Related Report
      2010 Final Research Report
  • [Presentation] キヌクリジノン還元酵素の機能改変を目指した構造解析2009

    • Author(s)
      宮川拓也、竹下大二郎、片岡道彦、熊代祥子、卯津羅淳子、野本史樹、永田宏次、清水昌、田之倉優
    • Organizer
      バイオイメージング学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Rhodotorula rubra由来NADPH依存性3-キヌクリジノン還元酵素2009

    • Author(s)
      卯津羅淳子、片岡道彦、北村苗穂子、斎藤英樹、野本史樹、佐古田昭子、西本幸史、清水昌
    • Organizer
      日本ビタミン学会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-30
    • Related Report
      2010 Final Research Report
  • [Presentation] カルボニル還元酵素S1の基質認識機構の構造学的解析2009

    • Author(s)
      諏訪陽一、片岡道彦、Fabiana Lica Imai、宮川拓也、岡井公彦、永田宏次、八十原良彦、木崎憲之、清水昌、田之倉優
    • Organizer
      蛋白質科学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] キヌクリジノン還元酵素の機能改変を目指した構造解析2009

    • Author(s)
      宮川拓也、竹下大二郎、片岡道彦、熊代祥子、卯津羅淳子、野本史樹、永田宏次、清水昌、田之倉優
    • Organizer
      蛋白質科学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 2段階不斉還元反応による(4R, 6R)-actinolの生産2009

    • Author(s)
      上敷領俊、桑原ふみ、浦野信行、片岡道彦、清水昌
    • Organizer
      日本農芸化学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Agrobacterium tumefaciens由来NADH 依存性キヌクリジノン還元酵素の機能改変を目指した構造解析2009

    • Author(s)
      宮川拓也、片岡道彦、熊代祥子、竹下大二郎、野本史樹、永田宏次、清水昌、田之倉優
    • Organizer
      日本農芸化学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Rhodotorula rubra由来NADPH依存性キヌクリジノン還元酵素のX線結晶構造解析と酵素学的解析2009

    • Author(s)
      片岡道彦、竹下大二郎、熊代祥子、宮川拓也、卯津羅淳子、永田宏次、田之倉優、清水昌
    • Organizer
      日本農芸化学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] キラル化合物の不斉合成に利用可能なCandida macedoniensis由来旧黄色酵素の機能改変を目指した構造解析2009

    • Author(s)
      堀田彰一朗、丸岡慎太郎、大塚淳、永田宏次、片岡道彦、清水昌、田之倉優
    • Organizer
      日本農芸化学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Candidaparapsilosis由来共役ポリケトン還元酵素CPR-C2の機能改変を目指したX線結晶構造解析2009

    • Author(s)
      山村昭裕、丸岡慎太郎、大塚淳、永田宏次、片岡道彦、清水昌、田之倉優
    • Organizer
      日本農芸化学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] グリコールアルデヒドをグリオキサールに変換する酸化酵素2008

    • Author(s)
      礒部公安、加藤彩子、佐々木康孝、片岡道彦、小川順、岩崎晃、長谷川淳三、清水昌
    • Organizer
      酵素工学研究会
    • Place of Presentation
      千葉
    • Year and Date
      2008-11-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Screening of Novel Microbial Enzymes and their Application to Chiral Compound Production2008

    • Author(s)
      片岡道彦, 清水昌
    • Organizer
      Sustainable Biochemical and Chemical Engineering
    • Place of Presentation
      Germany
    • Year and Date
      2008-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Two novel old yellow enzymes catalyzing the stereospecific hydrogenation of C=C bond2008

    • Author(s)
      M.Kataoka, F.Kuwabara, N.Urano, S. Kamishikiryo, S.Shimizu
    • Organizer
      The 9th Swiss-Japanese Meeting on Biotechnology and Bioprocess Development
    • Place of Presentation
      Switzerland
    • Year and Date
      2008-10-27
    • Related Report
      2010 Final Research Report
  • [Presentation] A Novel Bioreduction System for Large-scale Production of Chiral Compoumds2008

    • Author(s)
      片岡道彦, 清水昌
    • Organizer
      The 4th Japan-Netherlands Joint Suminar on Enzyme Science and Biotechnology
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2008-09-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 旧黄色酵素-レボジオン還元酵素を用いた(4R, 6R)-アクチノールの生産2008

    • Author(s)
      上敷領俊、桑原ふみ、浦野信行、片岡道彦、清水昌
    • Organizer
      日本農芸化学会関西支部
    • Place of Presentation
      京都
    • Year and Date
      2008-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 微生物機能を活用した有用物質生産のバイオプロセス化2008

    • Author(s)
      片岡道彦、清水昌
    • Organizer
      日本農芸化学会関西支部
    • Place of Presentation
      京都
    • Year and Date
      2008-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Two novel old yellow enzymes catalyzing the asymmetric hydrogenation of C=C bond2008

    • Author(s)
      M.Kataoka, F.Kuwabara, S. Kamishikiryo, S.Shimizu
    • Organizer
      Fourth Internatinational Congress on Blocatalysis
    • Place of Presentation
      Germany
    • Year and Date
      2008-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Two Novel Old Yellow Enzymes Catalyzing the Asymmetric Hydrogenation of C=C Bond2008

    • Author(s)
      Kataoka, M., et al.
    • Organizer
      biocat 2008
    • Place of Presentation
      ドイツ・ハンブルク
    • Year and Date
      2008-09-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Screening of Novel Microbial Enzymes and their Applications to the Large-scale Production of Useful Chemicals2008

    • Author(s)
      片岡道彦
    • Organizer
      Gordon Research Conference, BIOCATALYSIS
    • Place of Presentation
      Smithfield, USA
    • Year and Date
      2008-07-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 炭素二重結合を不斉水素化する2つの新規な旧黄色酵素2008

    • Author(s)
      片岡道彦、桑原ふみ、浦野信行、上敷領俊、清水昌
    • Organizer
      日本ビタミン学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-06-13
    • Related Report
      2010 Final Research Report
  • [Book] Encyclopedia of Industrial Biotechnology : Bioprocess, Bioseparation, and Cell Technology2010

    • Author(s)
      S. Shimizu, M. Kataoka
    • Publisher
      John Wiley & Sons Inc
    • Related Report
      2010 Final Research Report
  • [Book] 酵素利用技術大系2010

    • Author(s)
      片岡道彦、清水昌
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Book] ビタミンの総合事典(日本ビタミン学会編)2010

    • Author(s)
      片岡道彦、清水昌
    • Publisher
      朝倉書店
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Book] Encyclopedia of Industrial Biotechnology : Bioprocess, Bioseparation, and Cell Technology2010

    • Author(s)
      S.Shimizu, M.Kataoka
    • Publisher
      John Wiley & Sons Inc
    • Related Report
      2010 Annual Research Report
  • [Book] 第二世代バイオ燃料の開発と応用展開 (植田充美, 福崎英一郎監修)2009

    • Author(s)
      片岡道彦, 浦野信行, 清水昌
    • Total Pages
      239
    • Publisher
      シーエムシー出版
    • Related Report
      2009 Annual Research Report
  • [Book] Screening of novel microbial enzymes and their application to chiral compound production. Biocatalysis and Bioenergy (C.T. Hou, J.-F. Shaw eds.)2008

    • Author(s)
      M. Kataoka, S. Shimizu
    • Publisher
      John Wiley & Sons Co
    • Related Report
      2010 Final Research Report
  • [Book] John Wiley & Sons.2008

    • Author(s)
      Kataoka, M., 他
    • Publisher
      Biocatalysis and Bioenergy
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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