Development of microbial production system using bioreduction system

• Project/Area Number: 20380051
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied microbiology
• Research Institution: Kyoto University
• Principal Investigator: KATAOKA Michihiko Kyoto University, 生命環境科学研究科, 教授 (90252494)
• Co-Investigator(Kenkyū-buntansha): 小川 順 京都大学, 農学研究科, 教授 (70281102) ; 萩下 大郎 京都大学, 農学研究科, 准教授 (20432346) ; 清水 昌 京都大学, 農学研究科, 教授 (70093250)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Jun 京都大学, 農学研究科, 教授 (70281102)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: バイオ還元 / 不斉還元 / 補酵素再生 / 旧黄色酵素 / モノオキシゲナーゼ / ラクトン

Research Abstract

Bioreduction system using an E. coli transformant co-expressing NAD(P)H-dependent enzyme and cofactor regeneration enzyme genes was applied to the production of other useful compounds. The reactions requiring NAD(P)H as a cofactor, such as C=C bond reductions and monooxigenation were exammined.

Research Products

• [Journal Article] Directed evolution of an aminoalcohol dehydrogenase for efficient production of double chiral aminoalcohols (2011)
  • Author(s): N. Urano, S. Fukui, S. Kumashiro, T. Ishige, S. Kita, K. Sakamoto, M.Kataoka, S.Shimizu
  • Journal Title: J.Biosci.Bioeng. 111 Pages: 266-271
  • NAID: 110008593154
  • Peer Reviewed
• [Journal Article] Genetic analysis around aminoalcohol dehydrogenase gene of Rhodococcus erythropolis MAK154 : a putative GntR transcription factor in transcriptional regulation. Appl. (2011)
  • Author(s): N.Urano, M.Kataoka, T. Ishige, S. Kita, K. Sakamoto, S.Shimizu
  • Journal Title: Microbiol.Biotechnol. 89 Pages: 739-746
  • Peer Reviewed
• [Journal Article] Genetic analysis around aminoalcohol dehydrogenase gene of Rhodococcus erythropolis MAK154 : a putative GntR transcription factor in transcriptional regulation. (2011)
  • Author(s): N.Urano, M.Kataoka, T.Ishige, S.Kita, K.Sakamoto, S.Shimizu
  • Journal Title: Appl.Microbiol.Biotechnol Volume: 89 Pages: 739-746
  • Peer Reviewed
• [Journal Article] Directed evolution of an aminoalcohol dehydrogenase for efficient production of double chiral aminoalcohols (2011)
  • Author(s): N.Urano, S.Fukui, S.Kumashiro, T.Ishige, S.Kita, K.Sakamoto, M.Kataoka, S.Shimizu
  • Journal Title: J.Biosci.Bioeng Volume: 111 Pages: 266-271
  • NAID: 110008593154
  • Peer Reviewed
• [Journal Article] Cloning, sequencing and expression analysis of a gene encoding alcohol oxidase in Paenibacillus sp. AIU 311. (2010)
  • Author(s): Y. Sasaki, M.Kataoka, N.Urano, J. Ogawa, A. Iwasaki, J. Hasegawa, K. Isobe, S.Shimizu
  • Journal Title: J.Biosci.Bioeng. 110 Pages: 147-151
  • NAID: 110007700561
  • Peer Reviewed
• [Journal Article] Characterization of the ubiquinone binding site in alternative NADH-quinone oxidoreductase of Saccharomyces cerevisiae by photoaffinity labeling. (2010)
  • Author(s): M. Murai, T. Yamashita, M. Senoh, Y. Mashimo, M.Kataoka, H. Kosaka, A. Matsuno-Yagi, T. Yagi, H. Miyoshi
  • Journal Title: Biochemistry. 49 Pages: 2973-2980
  • Peer Reviewed
• [Journal Article] 不斉水素添加触媒としての「旧黄色酵素」の機能開発 (2010)
  • Author(s): 片岡道彦、浦野信行、堀田彰一朗、宮川拓也、田之倉優、清水昌
  • Journal Title: 酵素工学ニュース 第64号 Pages: 11-166
• [Journal Article] Characterization of the ubiquinone binding site in alternative NADH-quinone oxidoreductase of Saccharomyces cerevisiae by photoaffinity labeling. (2010)
  • Author(s): M.Murai, T.Yamashita, M.Senoh, Y.Mashimo, M.Kataoka, H.Kosaka, A.Matsuno-Yagi, T.Yagi, H.Miyoshi
  • Journal Title: Biochemistry Volume: 49 Pages: 2973-2980
  • Peer Reviewed
• [Journal Article] Cloning, sequencing and expression analysis of a gene encoding alcohol oxidase in Paenibacillus sp.AIU 311. (2010)
  • Author(s): Y.Sasaki, M.Kataoka, N.Urano, J.Ogawa, A.Iwasaki, J.Hasegawa, K.Isobe, S.Shimizu
  • Journal Title: J.Biosci.Bioeng Volume: 110 Pages: 147-151
  • Peer Reviewed
• [Journal Article] 不斉水素添加触媒としての「旧黄色酵素」の機能開発 (2010)
  • Author(s): 片岡道彦、浦野信行、堀田彰一朗、宮川拓也、田之倉優、清水昌
  • Journal Title: 酵素工学ニュース Volume: 第64号 Pages: 11-16
• [Journal Article] Expression, purification, crystallization and preliminary X-ray analysis of conjugated polyketone reductase C2 (CPR-C2) from Candida parapsilosis IFO 0708. (2009)
  • Author(s): A. Yamamura, S. Maruoka, J. Ohtsuka, T.Miyakawa, K. Nagata, M.Kataoka, N. Kitamura, S.Shimizu, M.Tanokura
  • Journal Title: Acta Crystal. F65 Pages: 1145-1148
  • Peer Reviewed
• [Journal Article] Crystallization and preliminary X-ray analysis of the NADPH-dependent 3-quinuclidinone reductase from Rhodotorula rubra. (2009)
  • Author(s): D. Takeshita, M.Kataoka, T.Miyakawa, K. Miyazono, A. Uzura, K. Nagata, S.Shimizu, M.Tanokura
  • Journal Title: Acta Crystal. F65 Pages: 645-647
  • Peer Reviewed
• [Journal Article] Steroselective synthesis of (R)-3-quinuclidinol through asymmetric reduction of 3-quinuclidinone with NADPH-dependent 3-quinuclidinone reductase from Rhodotorula rubra. (2009)
  • Author(s): A. Uzura, F. Nomoto, A. Sakoda, Y. Nishimoto, M.Kataoka, S.Shimizu
  • Journal Title: Appl.Microbiol.Biotechnol. 83 Pages: 617-626
  • Peer Reviewed
• [Journal Article] Production and characterization of alcohol oxidase from Penicillium purpurescens AIU063. (2009)
  • Author(s): K. Isobe, T. Takahashi, M.Kataoka, J. Ogawa, S.Shimizu
  • Journal Title: J.Biosci.Bioeng. 107 Pages: 108-112
  • NAID: 110007110228
  • Peer Reviewed
• [Journal Article] Stereoselective synthesis of (R)-3-quinuclidinol through asymmetric reduction of 3-quinuclidinone with 3-quinuclidinone reductase of Rhodotorula rubra (2009)
  • Author(s): Uzura A, Nomoto F, Sakoda A, Nishimoto Y, Kataoka M, Shimizu S.
  • Journal Title: Appl.Microbiol.Biotechnol 83 Pages: 617-626
  • Peer Reviewed
• [Journal Article] Crystallization and preliminary X-ray analysis of the NADPH-dependent 3-auinuclidinone reductase from Rhodotorula rubra (2009)
  • Author(s): Takeshita D, Kataoka M, Miyakawa T, Miyazono K, Uzura A, Nagata K, Shimizu S, Tanokura M.
  • Journal Title: Acta Crystallogr.Sect.F Struct.Biol.Cryst Commun 65 Pages: 645-647
  • Peer Reviewed
• [Journal Article] Expression, purification, crystallization and preliminary X-ray analysis of conjugated polyketone reductase C2 (CPR-C2) from Candida parapsilosis IFO 0708 (2009)
  • Author(s): Yamamura A, Maruoka S, Ohtsuka J, Miyakawa T, Nagata K, Kataoka M, Kitamura N, Shimizu S, Tanokura M.
  • Journal Title: Acta Crystallogr.Sect.F Struct.Biol.Cryst Common 65 Pages: 1145-1148
  • Peer Reviewed
• [Journal Article] Purification and characterization of a new aldehyde oxidase from Pseudomonas sp. AIU 362. (2008)
  • Author(s): Y. Sasaki, K. Isobe, M.Kataoka, J. Ogawa, A. Iwasaki, J. Hasegawa, S.Shimizu
  • Journal Title: J.Biosci.Bioeng. 106 Pages: 297-302
  • NAID: 110006950582
  • Peer Reviewed
• [Journal Article] Cloning and expression of the L-1-amino-2-propanol dehydrogenase gene from Rhodococcus erythropolis, and its application to double chiral compound production. (2008)
  • Author(s): M.Kataoka, T. Ishige, N.Urano, Y. Nakamura, E. Sakuradani, S. Fukui, S. Kita, K. Sakamoto, S.Shimizu
  • Journal Title: Appl.Microbiol.Biotechnol. 80 Pages: 597-604
  • Peer Reviewed
• [Journal Article] Aldehyde oxidase carrying an unusual subunit structure from Pseudomonas sp. MX-058. (2008)
  • Author(s): R. Thiwthong, M.Kataoka, A. Iwasaki, H. Watanabe, J. Hasegawa, K. Isobe, S.Shimizu
  • Journal Title: Microbial. Biotechnol. 1 Pages: 395-402
  • Peer Reviewed
• [Journal Article] Superoxide dismutase exhibit oxidase activity on aldehyde alcohols similar to alcohol oxidase from Paenibacillus sp. AIU311. (2008)
  • Author(s): K. Isobe, A. Kato, Y. Sasaki, M.Kataoka, J. Ogawa, A. Iwasaki, J. Hasegawa, S.Shimizu
  • Journal Title: J.Biosci.Bioeng. 105 Pages: 666-670
  • NAID: 110006792545
  • Peer Reviewed
• [Journal Article] Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari : Carpoglyphidae). (2008)
  • Author(s): K. Noge, N. Kato, N. Mori, M.Kataoka, C. Tanaka, Y. Yamasue, R. Nishida, Y. Kuwahara
  • Journal Title: FEBS J. 275 Pages: 2807-2817
  • Peer Reviewed
• [Journal Article] Cloning and expression of the L-1-amino-2-propanol dehydrogenase gene from Rhodococcus erythropolis, and its application to double chiral compound production (2008)
  • Author(s): Kataoka, M., et al.
  • Journal Title: Appl. Microbiol. Biotechnol. 80 Pages: 597-604
  • Peer Reviewed
• [Journal Article] Aldehyde oxidase carrying an unusual subunit structure from Pseudomonas sp. MX-058 (2008)
  • Author(s): Thiwthong, R., et al.
  • Journal Title: Microbial Biotechnol. 1 Pages: 395-402
  • Peer Reviewed
• [Journal Article] Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari : Carpoglyphidae) (2008)
  • Author(s): Noge, K., et al.
  • Journal Title: FEBS J. 275 Pages: 2807-2817
  • Peer Reviewed
• [Presentation] A putative TetR transcription factor in transcriptional regulation of L-pantoyl lactone dehydrogenase gene of Rhodococcus erythropolis (2011)
  • Author(s): D. Si, N.Urano, S.Shimizu, M.Kataoka
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-28
• [Presentation] 環境調和型バイオプロセスに有用な微生物酵素の構造機能解析-キラル化合物合成酵素を中心として- (2011)
  • Author(s): 片岡道彦、宮川拓也、田之倉優、清水昌
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-28
• [Presentation] 基質特異性の異なる2種の旧黄色酵素の構造情報に基づく機能改変 (2011)
  • Author(s): 片岡道彦、堀田彰一朗、中川拓哉、北村苗穂子、宮川拓也、大塚淳、永田宏次、田之倉優、清水昌
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-26
• [Presentation] キラル化合物合成に応用可能な2種の旧黄色酵素の結晶構造解析とその異なる基質特異性の構造基盤 (2011)
  • Author(s): 堀田彰一朗、片岡道彦、北村苗穂子、宮川拓也、大塚淳、永田宏次、清水昌、田之倉優
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-26
• [Presentation] カルボニル還元酵素S1の基質認識機構の構造学的解析 (2010)
  • Author(s): 諏訪陽一、片岡道彦、イマイファビアナリカ、永井貴大、北村苗穂子、宮川拓也、岡井公彦、清水昌、田之倉優
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] カルボニル還元酵素S1の基質認識機構の構造学的解析 (2010)
  • Author(s): 諏訪陽一、片岡道彦、イマイファビアナリカ、永井貴大、北村苗穂子、宮川拓也、岡井公彦、清水昌、田之倉優
  • Organizer: 第48回日本生物物理学会年会
  • Place of Presentation: 宮城
  • Year and Date: 2010-09-20
• [Presentation] A Novel Aocohol Oxidase from Paenibacillus sp. AIU 311 and Its Application (2010)
  • Author(s): K. Isobe, Y.Sasaki, M.Kataoka, N.Urano, J.Ogawa, A.Iwasaki, J.Hasegawa, S.Shimizu
  • Organizer: 14th International Biotechnology Symposium and Exhibition
  • Place of Presentation: Italy
  • Year and Date: 2010-09-15
• [Presentation] 炭素二重結合を不斉水素化する2種の旧黄色酵素の構造機能解析 (2010)
  • Author(s): 片岡道彦、浦野信行、北村苗穂子、堀田彰一朗、宮川拓也、大塚淳、永田宏次、田之倉優、清水昌
  • Organizer: 2010年度酵素・補酵素研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-10
• [Presentation] カルボニル還元酵素S1の基質認識機構の構造学的解析 (2010)
  • Author(s): 諏訪陽一、片岡道彦、イマイファビアナリカ、永井貴大、北村苗穂子、宮川拓也、岡井公彦、永田宏次、清水昌、田之倉優
  • Organizer: 第19回日本バイオイメージング学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-09
• [Presentation] 炭素二重結合を不斉水素化する2種の旧黄色酵素の構造機能解析 (2010)
  • Author(s): 片岡道彦、浦野信行、北村苗穂子、堀田彰一朗、宮川拓也、大塚淳、永田宏次、田之倉優、清水昌
  • Organizer: 食品酵素化学研究会第10回学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-04
• [Presentation] D-パントイルラクトン合成酵素CPR-C2の機能改変に向けたX線結晶構造解析 (2010)
  • Author(s): 山村昭裕、丸岡慎太郎、大塚淳、宮川拓也、永田宏次、片岡道彦、北村苗穂子、清水昌、田之倉優
  • Organizer: 第10回日本蛋白質化学会年会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-18
• [Presentation] キラル化合物合成に有用な2種類の旧黄色酵素の結晶構造解析と基質特異性に関する構造基盤 (2010)
  • Author(s): 堀田彰一朗、片岡道彦、北村苗穂子、宮川拓也、大塚淳、永田宏次、清水昌、田之倉優
  • Organizer: 第10回日本蛋白質化学会年会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-16
• [Presentation] キラル化合物合成に有用な2種類の旧黄色酵素の結晶構造解析と基質特異性に関する構造基盤 (2009)
  • Author(s): 堀田彰一朗、片岡道彦、北村苗穂子、宮川拓也、大塚淳、永田宏次、清水昌、田之倉優
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Paenibacillus sp. AIU311が産生するアルデヒドアルコールに特異的なオキシダーゼ (2009)
  • Author(s): 礒部公安、加藤彩子、佐々木康孝、浦野信行、片岡道彦、小川順、岩崎晃、長谷川淳三、清水昌
  • Organizer: 生体触媒化学シンポジウム
  • Place of Presentation: 香川
  • Year and Date: 2009-12-03
• [Presentation] Old Y ellow Enzymes : Powerful biocatalyst for the asymmetric hydrogenation of C=C bond (2009)
  • Author(s): M.Kataoka, F.Kuwabara, N.Urano, S. Kamishikiryo, S.Shimizu
  • Organizer: BioMicroWorld 2009
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2009-12-02
• [Presentation] Paenibacillus属細菌由来グリコールアルデヒドオキシダーゼ遺伝子のクローニングと大腸菌での発現E.coli菌体によるグリコールアルデヒドのオキサールへの変換 (2009)
  • Author(s): 佐々木康孝、礒部公安、浦野信行、片岡道彦、小川順、岩崎晃、長谷川淳三、清水昌
  • Organizer: 日本農芸化学会東北支部
  • Place of Presentation: 岩手
  • Year and Date: 2009-10-31
• [Presentation] Crystal structure of Escherichia coli low-specific L-threonine aldolase (2009)
  • Author(s): Fabiana Lica Imai, M.Kataoka, T.Miyakawa, K. Miyazono, M.Okai, K.Nagata, S.Shimizu, M. Tanokura
  • Organizer: 日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] Bioreduction system for chiral technology (2009)
  • Author(s): Michihiko Kataoka, Nobuyuki Urano, Nahoko Kitamura, Sakayu Shimizu
  • Organizer: 15th German-Japanese Workshop on Enzyme Technology
  • Place of Presentation: University of Rostock, Germany
  • Year and Date: 2009-09-26
• [Presentation] Bioreduction system for chiral technology-the stereoselective synthesis of (R)-3-quinuclidinol- (2009)
  • Author(s): 片岡道彦, 浦野信行, 北村苗穂, 清水昌
  • Organizer: 15th German-Japanese Workshop on Enzyme Technology
  • Place of Presentation: Germany
  • Year and Date: 2009-09-21
• [Presentation] Two novel carbonyl reductases from yeast and bacterial strains, and their application to the stereoselective synthesis of (R)-3-quinuclidinol (2009)
  • Author(s): M.Kataoka, A. Uzura, F.Nomoto, N.Urano, N.Kitamura, S.Shimizu
  • Organizer: Enzyme Engineering XX
  • Place of Presentation: The Netherlands
  • Year and Date: 2009-09-20
• [Presentation] キヌクリジノン還元酵素の機能改変を目指した構造解析 (2009)
  • Author(s): 宮川拓也、竹下大二郎、片岡道彦、熊代祥子、卯津羅淳子、野本史樹、永田宏次、清水昌、田之倉優
  • Organizer: バイオイメージング学会
  • Place of Presentation: 岡山
  • Year and Date: 2009-09-03
• [Presentation] Rhodotorula rubra由来NADPH依存性3-キヌクリジノン還元酵素 (2009)
  • Author(s): 卯津羅淳子、片岡道彦、北村苗穂子、斎藤英樹、野本史樹、佐古田昭子、西本幸史、清水昌
  • Organizer: 日本ビタミン学会
  • Place of Presentation: 京都
  • Year and Date: 2009-05-30
• [Presentation] カルボニル還元酵素S1の基質認識機構の構造学的解析 (2009)
  • Author(s): 諏訪陽一、片岡道彦、Fabiana Lica Imai、宮川拓也、岡井公彦、永田宏次、八十原良彦、木崎憲之、清水昌、田之倉優
  • Organizer: 蛋白質科学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-20
• [Presentation] キヌクリジノン還元酵素の機能改変を目指した構造解析 (2009)
  • Author(s): 宮川拓也、竹下大二郎、片岡道彦、熊代祥子、卯津羅淳子、野本史樹、永田宏次、清水昌、田之倉優
  • Organizer: 蛋白質科学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-20
• [Presentation] 2段階不斉還元反応による(4R, 6R)-actinolの生産 (2009)
  • Author(s): 上敷領俊、桑原ふみ、浦野信行、片岡道彦、清水昌
  • Organizer: 日本農芸化学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-27
• [Presentation] Agrobacterium tumefaciens由来NADH 依存性キヌクリジノン還元酵素の機能改変を目指した構造解析 (2009)
  • Author(s): 宮川拓也、片岡道彦、熊代祥子、竹下大二郎、野本史樹、永田宏次、清水昌、田之倉優
  • Organizer: 日本農芸化学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-27
• [Presentation] Rhodotorula rubra由来NADPH依存性キヌクリジノン還元酵素のX線結晶構造解析と酵素学的解析 (2009)
  • Author(s): 片岡道彦、竹下大二郎、熊代祥子、宮川拓也、卯津羅淳子、永田宏次、田之倉優、清水昌
  • Organizer: 日本農芸化学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-27
• [Presentation] キラル化合物の不斉合成に利用可能なCandida macedoniensis由来旧黄色酵素の機能改変を目指した構造解析 (2009)
  • Author(s): 堀田彰一朗、丸岡慎太郎、大塚淳、永田宏次、片岡道彦、清水昌、田之倉優
  • Organizer: 日本農芸化学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-27
• [Presentation] Candidaparapsilosis由来共役ポリケトン還元酵素CPR-C2の機能改変を目指したX線結晶構造解析 (2009)
  • Author(s): 山村昭裕、丸岡慎太郎、大塚淳、永田宏次、片岡道彦、清水昌、田之倉優
  • Organizer: 日本農芸化学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-27
• [Presentation] グリコールアルデヒドをグリオキサールに変換する酸化酵素 (2008)
  • Author(s): 礒部公安、加藤彩子、佐々木康孝、片岡道彦、小川順、岩崎晃、長谷川淳三、清水昌
  • Organizer: 酵素工学研究会
  • Place of Presentation: 千葉
  • Year and Date: 2008-11-17
• [Presentation] Screening of Novel Microbial Enzymes and their Application to Chiral Compound Production (2008)
  • Author(s): 片岡道彦, 清水昌
  • Organizer: Sustainable Biochemical and Chemical Engineering
  • Place of Presentation: Germany
  • Year and Date: 2008-11-05
• [Presentation] Two novel old yellow enzymes catalyzing the stereospecific hydrogenation of C=C bond (2008)
  • Author(s): M.Kataoka, F.Kuwabara, N.Urano, S. Kamishikiryo, S.Shimizu
  • Organizer: The 9th Swiss-Japanese Meeting on Biotechnology and Bioprocess Development
  • Place of Presentation: Switzerland
  • Year and Date: 2008-10-27
• [Presentation] A Novel Bioreduction System for Large-scale Production of Chiral Compoumds (2008)
  • Author(s): 片岡道彦, 清水昌
  • Organizer: The 4th Japan-Netherlands Joint Suminar on Enzyme Science and Biotechnology
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2008-09-28
• [Presentation] 旧黄色酵素-レボジオン還元酵素を用いた(4R, 6R)-アクチノールの生産 (2008)
  • Author(s): 上敷領俊、桑原ふみ、浦野信行、片岡道彦、清水昌
  • Organizer: 日本農芸化学会関西支部
  • Place of Presentation: 京都
  • Year and Date: 2008-09-12
• [Presentation] 微生物機能を活用した有用物質生産のバイオプロセス化 (2008)
  • Author(s): 片岡道彦、清水昌
  • Organizer: 日本農芸化学会関西支部
  • Place of Presentation: 京都
  • Year and Date: 2008-09-12
• [Presentation] Two novel old yellow enzymes catalyzing the asymmetric hydrogenation of C=C bond (2008)
  • Author(s): M.Kataoka, F.Kuwabara, S. Kamishikiryo, S.Shimizu
  • Organizer: Fourth Internatinational Congress on Blocatalysis
  • Place of Presentation: Germany
  • Year and Date: 2008-09-04
• [Presentation] Two Novel Old Yellow Enzymes Catalyzing the Asymmetric Hydrogenation of C=C Bond (2008)
  • Author(s): Kataoka, M., et al.
  • Organizer: biocat 2008
  • Place of Presentation: ドイツ・ハンブルク
  • Year and Date: 2008-09-02
• [Presentation] Screening of Novel Microbial Enzymes and their Applications to the Large-scale Production of Useful Chemicals (2008)
  • Author(s): 片岡道彦
  • Organizer: Gordon Research Conference, BIOCATALYSIS
  • Place of Presentation: Smithfield, USA
  • Year and Date: 2008-07-06
• [Presentation] 炭素二重結合を不斉水素化する2つの新規な旧黄色酵素 (2008)
  • Author(s): 片岡道彦、桑原ふみ、浦野信行、上敷領俊、清水昌
  • Organizer: 日本ビタミン学会
  • Place of Presentation: 仙台
  • Year and Date: 2008-06-13
• [Book] Encyclopedia of Industrial Biotechnology : Bioprocess, Bioseparation, and Cell Technology (2010)
  • Author(s): S. Shimizu, M. Kataoka
  • Publisher: John Wiley & Sons Inc
• [Book] 酵素利用技術大系 (2010)
  • Author(s): 片岡道彦、清水昌
  • Publisher: エヌ・ティー・エス
• [Book] ビタミンの総合事典(日本ビタミン学会編) (2010)
  • Author(s): 片岡道彦、清水昌
  • Publisher: 朝倉書店
• [Book] Encyclopedia of Industrial Biotechnology : Bioprocess, Bioseparation, and Cell Technology (2010)
  • Author(s): S.Shimizu, M.Kataoka
  • Publisher: John Wiley & Sons Inc
• [Book] 第二世代バイオ燃料の開発と応用展開 (植田充美, 福崎英一郎監修) (2009)
  • Author(s): 片岡道彦, 浦野信行, 清水昌
  • Total Pages: 239
  • Publisher: シーエムシー出版
• [Book] Screening of novel microbial enzymes and their application to chiral compound production. Biocatalysis and Bioenergy (C.T. Hou, J.-F. Shaw eds.) (2008)
  • Author(s): M. Kataoka, S. Shimizu
  • Publisher: John Wiley & Sons Co
• [Book] John Wiley & Sons. (2008)
  • Author(s): Kataoka, M., 他
  • Publisher: Biocatalysis and Bioenergy