| Project/Area Number |
20380058
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied biochemistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KIMURA Tadashi 大阪大学, 医学(系)研究科, 教授 (90240845)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Yukihiko 熊本大学, 大学院・生命科学研究部, 教授 (80243038)
YAWO Hiromu 東北大学, 生命科学研究科, 教授 (00144353)
KURODA Kumi 独立行政法人理化学研究所, 黒田研究ユニット, ユニットリーダー (90391945)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
|---|
| Keywords | オキシトシン受容体 / オキシトシン / 母性行動 / セロトニン / 視索上核 / 視索前野 / Venus Venus / 大縫線核 / 社会行動 / アデノ随伴ヴィルス / 縫線核 / Venus |
|---|
| Research Abstract |
sing oxytocin receptor (OXTR)knockout mice and OXTR-Venus knockin mice, we analyzed the alteration in the expression of OXTR, when maternal behavior was induced after parturition. In the result, the number of Venus-positive cells, indicating expression of OXTR, increased significantly in the medial preoptic area (MPOA), known to be an essential region for maternal behavior, and in the supraoptic nucleus (SON), where most of OXT releasing cells are distributed, after parturition and during induction of maternal behavior. The increase of Venus-positive cells in MPOA and the SON in the virgin female mice after artificial (or forced)induction of maternal behavior were also detected. On the other hand, we newly cloned several TGF-beta related gene product as a potent"parturition-regulatory factors", from uterus of OXTR(-/-), Fp(-/-)double knockout female mice, prepared just after induced parturition.
|
