|Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
In this study, we analyzed the coordinated regulation between cell polarity and the cellcycle in yeast. We have identified a novel molecule in the MOR(Morphogenesis Orb6 Network) pathway that is important for establishment/ maintenance of cell polarity in fission yeast, and showed that the mitosis-to-interphase transition is coordinated by crosstalk between the SIN(Septation Initiation Network) and MOR pathways. Further, we found a new CCT(Cds1-Calcineurin-TIPs) pathway, in which calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth in fission yeast. As all the molecules in the CCT pathway are conserved ubiquitously, it is hoped that the similar mechanism is operational in human beings and new cancer therapeutics would be developed based upon this finding.