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Target identification of vauolating compound, vicenistatin.

Research Project

Project/Area Number 20380065
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionUniversity of Tsukuba

Principal Investigator

USUI Takeo  University of Tsukuba, 大学院・生命環境科学研究科, 准教授 (60281648)

Co-Investigator(Renkei-kenkyūsha) KANOH Naoki  東北大学, 大学院・薬学研究科, 准教授 (40317293)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywords液胞化 / 標的分子 / Chemical Biology
Research Abstract

Vicenistatin is an novel vacuolating compound, but its molecular mechanism has remained to be revealed. We found that vicenistatin interfered with the upstream factors of PIKfyve, a PI3P 5-kinase, or regulators involved in PI-turnover.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (5 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway.2010

    • Author(s)
      Chinen T., Nagumo Y., Watanabe T., Imaizumi T., Shibuya M., Kataoka T., Kanoh N., Iwabuchi Y., Usui T.
    • Journal Title

      Toxicol. Lett. 199

      Pages: 341-356

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of proteomic profiling based on 2-DIGE for classification of compounds according to the mechanism of action.2010

    • Author(s)
      Muroi M., Kazami S., Noda K., Kondo H., Takayama H., Kawatani M., Usui T., Osada H.
    • Journal Title

      Chem.Biol. 17

      Pages: 460-470

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of proteomic profiling based on 2-DIGE for classification of compounds according-to the mechanism of action2010

    • Author(s)
      Muroi, M., et al
    • Journal Title

      Chemistry & Biology

      Volume: 28 Pages: 460-470

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship study of glaziovianin A against cell cycleprogressi on and spindleformation of HeLa S3 cells.2010

    • Author(s)
      Ikedo, A., et al.
    • Journal Title

      Bioorganic Medicinal Chemistry Letters

      Volume: 20 Pages: 5402-5404

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irciniastatin A induces JNK activation that is involved incaspase-8-dependent apoptosis vra the mitochondrial pathway2010

    • Author(s)
      Chinen, T., et al.
    • Journal Title

      Toxicology Letters

      Volume: 199 Pages: 34-346

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Garbled messages and corrupted translations2010

    • Author(s)
      Schneider-Poetsch T., et al
    • Journal Title

      Nature Chemical Biology 6

      Pages: 189-198

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syntheses and biological evaluation of irciniastatin A and the C1-C2 alkyne analogue.2010

    • Author(s)
      Watanabe T., et al.
    • Journal Title

      Organic Letters 12

      Pages: 1040-1043

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells.2009

    • Author(s)
      Inaba S., et al.
    • Journal Title

      Journal of Antibiotics 62

      Pages: 507-512

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epoxyquinol B shows antiantiogenic and antitumor effects by inhi biting VEGFR2. EGFR. FGFR. and PDGFR.2008

    • Author(s)
      Kamiyama H, et al.
    • Journal Title

      Oncology Research 17

      Pages: 11-21

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation.2008

    • Author(s)
      Kamiyama H, et al.
    • Journal Title

      Journal of Antibiotics 61

      Pages: 94-97

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological activities of reveromycin A and spirofungin A derivatives.2008

    • Author(s)
      Shimizu T, et al.
    • Journal Title

      Bioorganic Medicinal Chemistry Letters 18

      Pages: 3756-3760

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 蛋白質-蛋白質相互作用阻害剤の解析2010

    • Author(s)
      臼井健郎
    • Organizer
      日本農芸化学会東北北海道支部合同第11回若手シンポジウム
    • Place of Presentation
      モンタナリゾート(宮城県)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Glaziovianin A, a new inhibitor of microtubule dynamics2010

    • Author(s)
      Usui, T.
    • Organizer
      International Symposium on Cell Functions Mediated by Small Molecules
    • Place of Presentation
      筑波大学
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] マーカーレス遺伝子破壊によるフォワードケミカルバイオロジー研究に向けた薬剤超感受性酵母の作成と利用2010

    • Author(s)
      臼井健郎
    • Organizer
      酵母研究会
    • Place of Presentation
      小西酒造(株)(兵庫県)
    • Year and Date
      2010-03-09
    • Related Report
      2010 Final Research Report
  • [Presentation] マーカーレス遺伝子破壊によるフォワードケミカルバイオロジー研究に向けた薬剤超感受性酵母の作成と利用2010

    • Author(s)
      臼井健郎
    • Organizer
      酵母研究会
    • Place of Presentation
      小西酒造(株)本社(兵庫県)
    • Year and Date
      2010-03-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛋白質一蛋白質相互作用阻害剤の解析2010

    • Author(s)
      臼井健郎
    • Organizer
      日本農芸化学会東北北海道支部合同第11回若手シンポジウム
    • Place of Presentation
      モンタナリゾート岩沼(宮城県岩沼市)
    • Related Report
      2010 Annual Research Report
  • [Book] Protein in Targeting with Small Molecules(Osada H.ed.)(Chapter 12 "Data on Small Molecules and Their Target Proteins")2009

    • Author(s)
      Usui T., Saito A., Osada H.
    • Related Report
      2010 Final Research Report
  • [Book] Chapter 12"Data on Small Molecules and Their Target Proteins"in Prote in Targeting with Small Molecules(H.Osada, ed.)2009

    • Author(s)
      Usui T., Saito A., Osada H
    • Total Pages
      289
    • Publisher
      Wiley
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.sakura.cc.tsukuba.ac.jp/~usui/index/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.sakura.cc.tsukuba.ac.jp/~usui/index/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.sakura.cc.tsukuba.ac.jp/~usui/index/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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