Target identification of vauolating compound, vicenistatin.
| Project/Area Number |
20380065
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
USUI Takeo University of Tsukuba, 大学院・生命環境科学研究科, 准教授 (60281648)
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| Co-Investigator(Renkei-kenkyūsha) |
KANOH Naoki 東北大学, 大学院・薬学研究科, 准教授 (40317293)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 液胞化 / 標的分子 / Chemical Biology |
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| Research Abstract |
Vicenistatin is an novel vacuolating compound, but its molecular mechanism has remained to be revealed. We found that vicenistatin interfered with the upstream factors of PIKfyve, a PI3P 5-kinase, or regulators involved in PI-turnover.
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Report
(4 results)
Research Products
(21 results)
